Synthesis and Antioxidant Properties of New Benzimidazole Derivatives

Öz

In this study, new benzimidazole derivatives were synthesized. After purity checks were made with Thin Layer Chromatography (TLC) and melting points, their structures were proved by mass spectroscopy, 1H, 13C NMR and elemental analysis technique. Antioxidant activities of the obtained materials were searched in terms of their effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, lipid peroxidation inhibition and ethoxyresorufin O-deethylase (EROD) enzyme activity. It was observed the compounds were generally moderately active in terms of DPPH radical scavenging activity and lipid peroxidation inhibition compared to the standard compound and had a good effect on EROD enzyme activity.

Anahtar Kelimeler

• DPPH
• EROD enzyme activity
• 1,3,4-oxadiazole

Synthesis and Antioxidant Properties of New Benzimidazole Derivatives

Öz

Bu çalışmada yeni benzimidazol türevleri sentezlenmiştir. İnce Tabaka Kromatografisi (TLC) ve erime noktaları ile saflık kontrolleri yapıldıktan sonra yapıları kütle spektroskopisi, 1H, 13C NMR ve element analizi teknikleri ile kanıtlanmıştır. Elde edilen bileşiklerin antioksidan aktiviteleri, 2, 2-difenil-1-pikrilhidrazil (DPPH) radikal temizleme aktivitesi, lipit peroksidasyon inhibisyonu ve etoksresorufin O-deetilaz (EROD) enzim aktivitesi üzerindeki etkileri açısından araştırılmıştır. Bileşikler, standart bileşik ile karşılaştırıldığında DPPH radikal temizleme aktivitesi ve lipit peroksidasyon inhibisyonu açısından genellikle orta derecede ve EROD enzim aktivitesi üzerinde iyi bir etkiye sahip olduğu gözlenmiştir.

Anahtar Kelimeler

• DPPH
• EROD enzyme activity
• 1,3,4-oxadiazole

Kaynakça

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