The Effect Of Polymer Concentration On Coaxial Electrospinning Of Pvp/Pcl Core-Sheath Nanofibers

Yıl 2024, Cilt: 27 Sayı: 5, 1781 - 1787, 02.10.2024

Fatma Banu Nergis , Nebahat Aral Yılmaz , Nursema Pala Avcı

https://doi.org/10.2339/politeknik.1307935

Cited By: 1

Öz

Core-sheath nanofibers are being developed with coaxial electrospinning for use in drug release studies. In this study, nanofiber structures were developed as hydrophobic PCL in the sheath and hydrophilic PVP in the core. The effect of polymer concentrations on fiber structure and water contact angle was observed by forming two different test groups. In the first group, fiber diameters were observed to decrease depending on viscosity as the polymer concentration decreased from 10% PCL / 10% PVP to 6% PCL / 6% PVP. It was also observed that the contact angle decreased from 104.3° to 57.61° as the concentration decreased. In the second group, the shell polymer ratio was kept constant as 10% wt PCL, while the core polymer ratio was decreased to 10 %, 8% and 6%. It was observed that the core polymer in the structure became hydrophilic as its viscosity decreased. Compared to the first group, the decrease in the contact angles of the surfaces was less since the shell polymer ratio was kept constant. Contact angles decreased from 104.3° to 96.29°.

Anahtar Kelimeler

Nanofiber, Coaxial Electrospinning, Polycaprolactone, Polyvinylpyrrolidone

Destekleyen Kurum

Istanbul Technical University

Proje Numarası

MYL-2021-4327

Teşekkür

The authors gratefully acknowledge the funding by ITU-Graduate Thesis Program under the grant number MYL-2021-4327.

Polimer Konsantrasyonunun Koaksiyel Elektroeğrilmiş Pvp/Pcl Çekirdek-Kılıf Nanolifleri Üzerine Etkisi

Öz

Çekirdek-kabuk nanolifleri, ilaç salım çalışmalarında kullanılmak üzere koaksiyel elektroeğirme yöntemi ile geliştirilmektedir. Bu çalışmada, kabukta hidrofobik PCL ve çekirdekte hidrofilik PVP polimeri kullanılarak nanolifli yüzeyler geliştirilmiştir. Polimer konsantrasyonlarının lif yapısı ve su temas açısı üzerindeki etkisi iki farklı test grubu oluşturularak gözlemlendi. Birinci grupta polimer konsantrasyonu %10 PCL / %10 PVP'den %6 PCL / %6 PVP'ye düştüğü için lif çaplarının viskoziteye bağlı olarak azaldığı gözlendi. Ayrıca konsantrasyon azaldıkça temas açısının 104,3°'den 57,61°'ye düştüğü gözlendi. İkinci grupta kabuk polimer oranı ağırlıkça %10 PCL olarak sabit tutulurken çekirdek polimer oranı ağırlıkça %10, %8 ve %6 şeklinde azaltılarak nanolifli yüzey üretimleri yapıldı. Yapıdaki çekirdek polimerin viskozitesi azaldıkça yüzeylerin hidrofilik hale geldiği ve temas açılarının 104,3°'den 96,29°'ye düştüğü gözlendi. Birinci grup ile kıyaslandığında kabuk polimer oranı sabit tutulduğu için yüzeylerin temas açılarındaki azalma daha az olmuştur.

Anahtar Kelimeler

Nanolif, Eşeksenli Elektroeğirme, Polikaprolakton, Polivinilpirolidon

Proje Numarası

MYL-2021-4327

Kaynakça

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