Derleme
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Soğuk Atmosferik Plazma ve Kanser

Yıl 2021, Cilt: 01 Sayı: 02, 6 - 18, 31.12.2021

Öz

Plazma doğal bir gaza enerji eklenerek iyonize hale getirilmesiyle oluşmaktadır. Tedavi edilecek doku ve amaca göre sıcak plazma veya soğuk plazma uygulanmaktadır. Soğuk plazma uygulandığı doku ve çevresinde hasara neden olmaması nedeniyle klinik uygulamalarda daha çok tercih edilmektedir. Soğuk atmosferik plazma, plazmanın bir çeşidi olup ısıl etki olmaksızın dermotoloji alanında yara, kaşıntı, ağrı, yara izi, aktinik keratoz, diyabetik ayak ve egzama tedavisinde kullanılmasının yanı sıra son yıllarda dişçilikte beyazlatma, implant yüzeylerinin modifikasyonu, yüzey kaplama gibi uygulamalarda da sık sık kullanılmaya başlamıştır. Bu derleme yazısında öncelikle plazma hakkında genel bilgiler verilecek ardından soğuk atmosferik plazmanın kanser tedavisinde kullanımı incelenecektir.

Kaynakça

  • [1] M. Ansari, M. Sharifian, M. H. Ehrampoush, A. H. Mahvi, M. H. Salmani, and H. Fallahzadeh, "Dielectric barrier discharge plasma with photocatalysts as a hybrid emerging technology for degradation of synthetic organic compounds in aqueous environments: A critical review," Chemosphere, vol. 263, Jan 2021, Art no. 128065, doi: 10.1016/j.chemosphere.2020.128065.
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Cold Atmospheric Plasma and Cancer

Yıl 2021, Cilt: 01 Sayı: 02, 6 - 18, 31.12.2021

Öz

Plasma is formed by adding energy to a natural gas and ionizing it. Depending on the tissue to be treated and the purpose, hot plasma or cold plasma have been applied. Cold plasma is more preferred in clinical applications because it does not cause damage to the tissue and its surroundings. Cold atmospheric plasma is a type of plasma and it has been used in dermatology in the treatment of wounds, itching, pain, scarring, actinic keratosis, diabetic foot and eczema without thermal effect, as well as in applications such as bleaching, modification of implant surfaces, surface coating in dentistry in recent years. In this review article, firstly, general information about plasma will be given and then the use of cold atmospheric plasma in cancer treatment will be discussed.

Kaynakça

  • [1] M. Ansari, M. Sharifian, M. H. Ehrampoush, A. H. Mahvi, M. H. Salmani, and H. Fallahzadeh, "Dielectric barrier discharge plasma with photocatalysts as a hybrid emerging technology for degradation of synthetic organic compounds in aqueous environments: A critical review," Chemosphere, vol. 263, Jan 2021, Art no. 128065, doi: 10.1016/j.chemosphere.2020.128065.
  • [2] A. Bogaerts, E. Neyts, R. Gijbels, and J. van der Mullen, "Gas discharge plasmas and their applications," (in English), Spectrochimica Acta Part B-Atomic Spectroscopy, Review vol. 57, no. 4, pp. 609-658, Apr 2002, Art no. Pii s0584-8547(01)00406-2, doi: 10.1016/s0584-8547(01)00406-2.
  • [3] E. Feizollahi, N. N. Misra, and M. S. Roopesh, "Factors influencing the antimicrobial efficacy of Dielectric Barrier Discharge (DBD) Atmospheric Cold Plasma (ACP) in food processing applications," Critical Reviews in Food Science and Nutrition, vol. 61, no. 4, pp. 666-689, Feb 21 2021, doi: 10.1080/10408398.2020.1743967.
  • [4] N. Xu, X. L. Cui, Z. Fang, Y. W. Shi, and R. Y. Zhou, "A Two-Mode Portable Atmospheric Pressure Air Plasma Jet Device for Biomedical Applications," (in English), Ieee Transactions on Plasma Science, Article vol. 46, no. 4, pp. 947-953, Apr 2018, doi: 10.1109/tps.2018.2810142.
  • [5] F. Rezaei, B. Shokri, and M. Sharifian, "Atmospheric-pressure DBD plasma-assisted surface modification of polymethyl methacrylate: A study on cell growth/proliferation and antibacterial properties," Applied Surface Science, vol. 360, pp. 641-651, Jan 1 2016, doi: 10.1016/j.apsusc.2015.11.036.
  • [6] S. A. Mir, M. A. Shah, and M. M. Mir, "Understanding the Role of Plasma Technology in Food Industry," (in English), Food and Bioprocess Technology, Review vol. 9, no. 5, pp. 734-750, May 2016, doi: 10.1007/s11947-016-1699-9.
  • [7] S. Siadati, M. Pet'kova, A. J. Kenari, S. Kyzek, E. Galova, and A. Zahoranova, "Effect of a non-thermal atmospheric pressure plasma jet on four different yeasts," Journal of Physics D-Applied Physics, vol. 54, no. 2, Jan 14 2021, Art no. 025204, doi: 10.1088/1361-6463/abb624.
  • [8] H. W. Lee, S. H. Nam, A. A. H. Mohamed, G. C. Kim, and J. K. Lee, "Atmospheric Pressure Plasma Jet Composed of Three Electrodes: Application to Tooth Bleaching," (in English), Plasma Processes and Polymers, Article vol. 7, no. 3-4, pp. 274-280, Mar 2010, doi: 10.1002/ppap.200900083.
  • [9] Y. Wang, Z. Wang, H. Yang, and X. Zhu, "Gas phase surface discharge plasma model for yeast inactivation in water," Journal of Food Engineering, vol. 286, Dec 2020, Art no. 110117, doi: 10.1016/j.jfoodeng.2020.110117.
  • [10] N. Abramzon, J. C. Joaquin, J. Bray, and G. Brelles-Marino, "Biofilm destruction by RF high-pressure cold plasma jet," Ieee Transactions on Plasma Science, vol. 34, no. 4, pp. 1304-1309, Aug 2006, doi: 10.1109/tps.2006.877515.
  • [11] M. S. I. Khan, E.-J. Lee, and Y.-J. Kim, "A submerged dielectric barrier discharge plasma inactivation mechanism of biofilms produced by Escherichia coli O157: H7, Cronobacter sakazakii, and Staphylococcus aureus," Scientific Reports, vol. 6, Nov 15 2016, Art no. 37072, doi: 10.1038/srep37072.
  • [12] P. Guo et al., "A novel atmospheric-pressure air plasma jet for wound healing," (in English), International Wound Journal, Article; Early Access p. 15, Jul 2021, doi: 10.1111/iwj.13652.
  • [13] G. Fridman et al., "Blood coagulation and living tissue sterilization by floating-electrode dielectric barrier discharge in air," (in English), Plasma Chemistry and Plasma Processing, Article vol. 26, no. 4, pp. 425-442, Aug 2006, doi: 10.1007/s11090-006-9024-4.
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  • [37] T. J. Fan, L. H. Han, R. S. Cong, and J. Liang, "Caspase family proteases and apoptosis," (in English), Acta Biochimica Et Biophysica Sinica, Review vol. 37, no. 11, pp. 719-727, Nov 2005, doi: 10.1111/j.1745-7270.2005.00108.x.
  • [38] T. Adachi, H. Tanaka, S. Nonomura, H. Hara, S. Kondo, and M. Hod, "Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial-nuclear network," (in English), Free Radical Biology and Medicine, Article vol. 79, pp. 28-44, Feb 2015, doi: 10.1016/j.freeradbiomed.2014.11.014.
  • [39] A. Troyano, P. Sancho, C. Fernandez, E. de Blas, P. Bernardi, and P. Aller, "The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells," Cell Death and Differentiation, vol. 10, no. 8, pp. 889-898, Aug 2003, doi: 10.1038/sj.cdd.4401249.
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  • [41] S. Lee et al., "Cold atmospheric plasma restores tamoxifen sensitivity in resistant MCF-7 breast cancer cell," (in English), Free Radical Biology and Medicine, Article vol. 110, pp. 280-290, Sep 2017, doi: 10.1016/j.freeradbiomed.2017.06.017.
  • [42] A. Schmidt, S. Bekeschus, T. von Woedtke, and S. Hasse, "Cell migration and adhesion of a human melanoma cell line is decreased by cold plasma treatment," (in English), Clinical Plasma Medicine, Article vol. 3, no. 1, pp. 24-31, Jun 2015, doi: 10.1016/j.cpme.2015.05.003.
  • [43] M. Adhikari et al., "Cold Atmospheric Plasma as a Novel Therapeutic Tool for the Treatment of Brain Cancer," (in English), Current Pharmaceutical Design, Review vol. 26, no. 19, pp. 2195-2206, 2020, doi: 10.2174/1381612826666200302105715.
  • [44] X. Q. Cheng, J. Sherman, W. Murphy, E. Ratovitski, J. Canady, and M. Keidar, "The Effect of Tuning Cold Plasma Composition on Glioblastoma Cell Viability," (in English), Plos One, Article vol. 9, no. 5, p. 9, May 2014, Art no. e98652, doi: 10.1371/journal.pone.0098652.
  • [45] M. Akter, A. Jangra, S. A. Choi, E. H. Choi, and I. Han, "Non-Thermal Atmospheric Pressure Bio-Compatible Plasma Stimulates Apoptosis via p38/MAPK Mechanism in U87 Malignant Glioblastoma," Cancers, vol. 12, no. 1, Jan 2020, Art no. 245, doi: 10.3390/cancers12010245.
  • [46] G. E. Conway et al., "Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells," (in English), Scientific Reports, Article vol. 9, p. 12, Sep 2019, Art no. 12891, doi: 10.1038/s41598-019-49013-3.
  • [47] E. Tavares-da-Silva et al., "Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line," (in English), Biology-Basel, Article vol. 10, no. 1, p. 19, Jan 2021, Art no. 41, doi: 10.3390/biology10010041.
  • [48] H. Zhang et al., "Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids," (in English), Plasma Processes and Polymers, Article vol. 18, no. 10, p. 8, Oct 2021, Art no. e2100070, doi: 10.1002/ppap.202100070.
  • [49] N. Kaushik, N. Kumar, C. H. Kim, N. K. Kaushik, and E. H. Choi, "Dielectric Barrier Discharge Plasma Efficiently Delivers an Apoptotic Response in Human Monocytic Lymphoma," (in English), Plasma Processes and Polymers, Article vol. 11, no. 12, pp. 1175-1187, Dec 2014, doi: 10.1002/ppap.201400102.
  • [50] K. Panngom, K. Y. Baik, M. K. Nam, J. H. Han, H. Rhim, and E. H. Choi, "Preferential killing of human lung cancer cell lines with mitochondrial dysfunction by nonthermal dielectric barrier discharge plasma," (in English), Cell Death & Disease, Article vol. 4, p. 8, May 2013, Art no. e642, doi: 10.1038/cddis.2013.168.
  • [51] W. T. Li et al., "Cold atmospheric plasma and iron oxide-based magnetic nanoparticles for synergetic lung cancer therapy," (in English), Free Radical Biology and Medicine, Article vol. 130, pp. 71-81, Jan 2019, doi: 10.1016/j.freeradbiomed.2018.10.429.
  • [52] R. M. Walk et al., "Cold atmospheric plasma for the ablative treatment of neuroblastoma," Journal of Pediatric Surgery, vol. 48, no. 1, pp. 67-73, Jan 2013, doi: 10.1016/j.jpedsurg.2012.10.020.
  • [53] F. Saadati, H. Mahdikia, H. A. Abbaszadeh, M. A. Abdollahifar, M. S. Khoramgah, and B. Shokri, "Comparison of Direct and Indirect cold atmospheric-pressure plasma methods in the B16F10 melanoma cancer cells treatment," (in English), Scientific Reports, Article vol. 8, p. 15, May 2018, Art no. 7689, doi: 10.1038/s41598-018-25990-9.
  • [54] N. K. Kaushik, Y. H. Kim, Y. G. Han, and E. H. Choi, "Effect of jet plasma on T98G human brain cancer cells," (in English), Current Applied Physics, Article vol. 13, no. 1, pp. 176-180, Jan 2013, doi: 10.1016/j.cap.2012.07.002.
  • [55] M. Wang, B. Holmes, X. Q. Cheng, W. Zhu, M. Keidar, and L. G. Zhang, "Cold Atmospheric Plasma for Selectively Ablating Metastatic Breast Cancer Cells," (in English), Plos One, Article vol. 8, no. 9, p. 11, Sep 2013, Art no. e73741, doi: 10.1371/journal.pone.0073741.
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Toplam 65 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Elektrik Mühendisliği
Bölüm Araştırma Makaleleri
Yazarlar

Ayşe Özdemir 0000-0003-4050-6682

Yayımlanma Tarihi 31 Aralık 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 01 Sayı: 02

Kaynak Göster

IEEE A. Özdemir, “Soğuk Atmosferik Plazma ve Kanser”, Researcher, c. 01, sy. 02, ss. 6–18, 2021.
  • Yayın hayatına 2013 yılında başlamış olan "Researcher: Social Sciences Studies" (RSSS) dergisi, 2020 Ağustos ayı itibariyle "Researcher" ismiyle Ankara Bilim Üniversitesi bünyesinde faaliyetlerini sürdürmektedir.
  • 2021 yılı ve sonrasında Mühendislik ve Fen Bilimleri alanlarında katkıda bulunmayı hedefleyen özgün araştırma makalelerinin yayımlandığı uluslararası indeksli, ulusal hakemli, bilimsel ve elektronik bir dergidir.
  • Dergi özel sayılar dışında yılda iki kez yayımlanmaktadır. Amaçları doğrultusunda dergimizin yayın odağında; Endüstri Mühendisliği, Yazılım Mühendisliği, Bilgisayar Mühendisliği ve Elektrik Elektronik Mühendisliği alanları bulunmaktadır.
  • Dergide yayımlanmak üzere gönderilen aday makaleler Türkçe ve İngilizce dillerinde yazılabilir. Dergiye gönderilen makalelerin daha önce başka bir dergide yayımlanmamış veya yayımlanmak üzere başka bir dergiye gönderilmemiş olması gerekmektedir.