Evaluation of Hemogram Parameters Acccording to Blood Groups of COVID-19 Patients

Yıl 2022, Cilt: 12 Sayı: 2, 208 - 214, 17.05.2022

Zerrin Gamsızkan Abdulkadir Kaya Fatih Davran Mert Can Tuncel Abdullah Işık İdris Şahin

https://doi.org/10.33631/sabd.1108566

Öz

Aim: As the COVID-19 disease threatens the lives of many people all over the world, the laboratory parameters of the patients are examined in all respects. The relationship between blood types and COVID-19 has also been discussed in many studies.
The aim of this study is to examine the hemogram parameters of COVID-19 patients according to their blood groups.
Material and Methods: Our study is a retrospectively, designed descriptive, coross-sectional study. Patients who applied to the emergency pandemic outpatient clinic with the suspicion of COVID-19 between 01 December 2020 and 01 February 2021 were evaluated with blood groups and hemogram examinations.
Results: A total of 527 patients were included in the study. Of the patients, 31.1% (n=164) were male and 68.9% (n=363) were female. Of the patients included in the stıdy, 51.6% (n=272) were COVID-19 negative and 48.4%(n=255) were COVID-19 positive patients. No significant difference was observed between the COVID-19 diagnosed of the patients and their blood groups (p=0.799). No significant difference was observed between the paitents’ COVID-19 status and Rh factor (p=0.240). While there was no significant difference in lymphocyte and CRP values in the COVID-19 positive group (p>0.05); significant differences were observed in hemoglobin (p=0.028) and WBC (p=0.014) values.
Conclusion: In the results of the study, it was determined that there was no significant difference between COVID-19 positive and negative patients in terms of ABO blood group and Rh group. In additon, WBC and Hemoglobin levels were found to be significantly lower in PCR positive patients with AB blood group compared to other blood groups. Further studies are needed to explain the relationship between blood groups and laboratory parameters of COVID-19 positive patients.
in the development of children is emphasized.

Anahtar Kelimeler

COVID-19, ABO blood groups, hemogram

COVID-19 Hastalarının Kan Gruplarına Göre Hemogram Parametrelerinin Değerlendirilmesi

Öz

Amaç: COVID-19 hastalığı, tüm Dünyada birçok insanın hayatını tehdit ettiği için hastaların laboratuar parametreleri her açıdan incelenmektedir. Kan grupları ve COVID-19 ilişkisi de birçok araştırmada tartışılmıştır. Çalışmamızın amacı, COVID-19 hastalarının kan gruplarına göre hemogram parametrelerini incelemektir.
Gereç ve Yöntemler: Çalışmamız, retrospektif olarak tasarlanmış, tanımlayıcı-kesitsel bir çalışmadır. Çalışmada, 01.12.2020-01.02.2021 tarihleri arasında COVID-19 şüphesi ile acil pandemi polikliniğine başvuran hastalar kan grupları ve laboratuar tetkikleri ile değerlendirildi.
Bulgular: Çalışmaya toplam 527 hasta dahil edildi. Çalışmaya dahil edilen hastaların %31,1’i (n=164) erkek, %68,9’u (n=363) ise kadındı. Çalışmaya dahil edilen hastaların %51,6’sı (n=272) COVID-19 negatif, %48,4’ü (n=255) ise COVID-19 pozitifti. Hastaların COVID-19 tanıları ile kan grupları arasında anlamlı bir farklılık izlenmedi (p=0,799). Hastaların COVID-19 olma durumu ile Rh faktörü arasında anlamlı bir farklılık izlenmedi (p=0,240). COVID-19 pozitif grupta, lenfosit ve CRP değerlerinde anlamlı farklılık izlenmezken (p>0,05); hemoglobin (p=0,028) ve WBC (p=0,014) değerlerinde anlamlı farklılıklar izlendi.
Sonuç: Çalışma sonuçlarında ABO kan grubu ve Rh grubu açısından COVID-19 pozitif ve negatif hastalar açısından anlamlı bir fark olmadığı tespit edildi. Bununla birlikte, AB kan grubu olan PZR pozitif hastaların, WBC ve hemoglobin düzeylerinin diğer kan gruplarına göre anlamlı olarak düşüklük tespit edilmiştir. COVID pozitif hastaların kan grupları ile laboratuvar parametrelerinin ilişkisini açıklayabilmek için ileride yapılacak daha geniş kapsamlı araştırmalara ihtiyaç vardır.

Anahtar Kelimeler

COVID-19, ABO kan grupları, hemogram

Kaynakça

• Mukhtar S. Psychological health during the coronavirus disease 2019 pandemic outbreak. Int J Soc Psychiatry. 2020; 66(5): 512-6.
• Şeyhanlı E, Yasak İ. Diagnostic value of platelet mass ındex, Plt/Mpv ratio and other hemogram parameters in COVID-19 patients who presented to emergency department. Konuralp Medical Journal. 2021; 13(1): 101-7.
• Asan A, Üstündağ Y, Koca N, Şimşek A, Sayan HE, Parildar H, et al. Do initial hematologic indices predict the severity of COVID-19 patients? Turk J Med Sci. 2021; 51(1): 39-44.
• Zhao J, Yang Y, Huang H-P, Li D, Gu D-F, Lu X-F, et al. Relationship between the ABO blood group and the COVID-19 susceptibility. medRxiv. 2020.
• Gerard C, Maggipinto G, Minon JM. COVID-19 and ABO blood group: Another viewpoint. Br J Haematol. 2020; 190(2): e93-e94.
• Latz CA, DeCarlo C, Boitano L, Png CYM, Patell R, Conrad MF, et al. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020; 99(9): 2113-8.
• Cooling L. Blood Groups in Infection and Host Susceptibility. Clinical microbiology reviews. 2015; 28(3): 801-70.
• Beyazçiçek Ö, Beyazçiçek E, Demir S. Are blood groups protective against COVID-19? Konuralp Medical Journal. 2021; 13(1): 160-7.
• Alpdemir M, Alpdemir M, Kocaöz S, Ermiş T, Atlı A. Balıkesir bölgesinde ABO ve Rh kan grupları dağılımı. Balıkesir Sağlık Bilimleri Dergisi. 2014; 3 (2): 69-73.
• Ergün A, Yardımcı S. Türkiye Genelinde ABO kan grupları ve Rh faktörünün dağılımı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1993; 527-33.
• Torun AY, Kaynar LG, Karakükcü Ç, Yay M, Kurnaz F, Mutlu H, et al. ABO and Rh blood group distribution in Kayseri province. Turkey Turk J Hematol. 2012; 29: 97-8.
• Coluk Y, Hizli O, Gunaydın S, Yildirim G, Baysal E, Ozgen Hergul G. Association of blood subgroups with PCR test positivity and lung involvement in patients with COVID-19. Cureus. 2021; 13(3): e14172.
• Göker H, Aladağ Karakulak E, Demiroğlu H, Ayaz Ceylan ÇM, Büyükaşik Y, Inkaya AÇ, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020; 50(4): 679-83.
• Solmaz İ, Araç S. ABO blood groups in COVID-19 patients; Cross-sectional study. Int J Clin Pract. 2021; 75(4): e13927.
• Ray JG, Schull MJ, Vermeulen MJ, Park AL. Association between ABO and Rh blood groups and SARS-CoV-2 ınfection or severe COVID-19 Illness: A population-based cohort study. Ann Intern Med. 2021; 174(3): 308-15.
• Stowell CP, Stowell SR. Biologic roles of the ABH and Lewis histo-blood group antigens Part I: infection and immunity. Vox Sang. 2019; 114(5): 426-42.
• Wu BB, Gu DZ, Yu JN, Yang J, Shen WQ. Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis. Infect Genet Evol. 2020; 84: 104485.
• Pourali F, Afshari M, Alizadeh-Navaei R, Javidnia J, Moosazadeh M, Hessami A. Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis. New Microbes New Infect. 2020; 37: 100743
• Fan Q, Zhang W, Li B, Li DJ, Zhang J, Zhao F. Association between ABO blood group system and COVID-19 susceptibility in Wuhan. Front Cell Infect Microbiol. 2020; 10: 404.
• Mveang Nzoghe A, Padzys GS, Maloupazoa Siawaya AC, Kandet Yattara M, Leboueny M, Avome Houechenou RM, et al. Dynamic and features of SARS-CoV-2 infection in Gabon. Sci Rep. 2021; 11(1): 9672.
• Zietz M, Zucker J, Tatonetti NP. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun. 2020; 11(1): 5761.