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Hastanede Yatan Mutant ve Mutant Olmayan Virus ile Enfekte COVID-19 Hastalarında Kısa Süreli Fizyoterapinin Etkileri: Prospektif Bir Çalışma

Yıl 2024, Cilt: 14 Sayı: 3, 343 - 350, 19.09.2024
https://doi.org/10.33631/sabd.1435647

Öz

Amaç: Çalışmanın amacı, mutant ve mutant olmayan SARS-CoV-2 virüsü ile enfekte hastalar üzerinde fizyoterapinin kısa süreli etkilerini değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya dahil edilen hastalar 2 farklı grupta analiz edildi. Mutasyona uğramamış SARS-CoV-2 ile enfekte hastalar Grup 1'deydi (n=16; yaş=53,81±9,48). Mutasyona uğramış SARS-CoV-2 ile enfekte hastalar ise Grup 2’de (n=16; yaş=55,25±10,12) yer aldı. Her iki gruba da mobilizasyon, normal hareket açıklığı ve solunum egzersiz programını içeren fizyoterapi uygulandı (Grup 1: Medyan=7.00; Min-Max=5-20 gün; Grup 2: Medyan: 7.00; Min-Max=4-15 gün). Tüm hastalara günde bir kez fizyoterapi programı uygulandı. Hastaların kas kuvveti, mobilitesi, günlük yaşam aktiviteleri, egzersiz kapasitesi ve yorgunluk algısı değerlendirildi. Grupları karşılaştırmak için karma desenli tekrarlanan ölçümler ANOVA modeli kullanıldı.
Bulgular: Fizyoterapinin her iki grupta da kas kuvveti, mobilite, günlük yaşam aktivitelerini gerçekleştirme yeteneği, egzersiz kapasitesi ve yorgunluk algısını iyileştirdiği bulundu (p<0,05). Ek olarak, kas kuvveti (p=0,791), günlük yaşam aktiviteleri (p=0,410) ve mobilite (p=0,124) gibi değerlendirmelerin sonuçları da her iki grupta da benzer şekilde olumluydu. Her iki grupta da tedaviden sonra kalp hızı ve SpO2'de anlamlı bir değişiklik olmamıştır.
Sonuç: Mevcut çalışma, kısa süreli fizyoterapi programının mutasyona uğramış SARS-CoV-2 ile enfekte hastalarda, mutasyona uğramamış SARS-CoV-2 ile enfekte hastalarda olduğu kadar başarılı olduğunu göstermiştir. Fizyoterapi, kas kuvveti, mobilite, günlük yaşam aktiviteleri, egzersiz kapasitesi ve yorgunluk algısına olumlu katkı sağlayarak COVID-19 hastalığının fonksiyonel kısıtlılığını ve semptomlarını azalttığı için COVID-19 hastalığında faydalıdır.

Kaynakça

  • Lopez M, Bell K, Annaswamy T, Juengst S, Ifejika N. COVID-19 guide for the rehabilitation clinician: a review of nonpulmonary manifestations and complications. Am J Phys Med Rehabil. 2020; 99(8): 669-73.
  • Park M, Cook AR, Lim JT, Sun Y, Dickens BL. A systematic review of COVID-19 epidemiology based on current evidence. J Clin Med. 2020; 9(4): 1-13.
  • Onu I, Iordan D-A, Matei D, Hrisca-Eva O-D, Buculei I, Galaction A-I, et al. Impact of physiotherapy on patients suffering from COVID-19: An observational study. Applied Sciences. 2022; 12(12): 1-13.
  • Lemhöfer C, Gutenbrunner C, Schiller J, Loudovici-Krug D, Best N, Bökel A, et al. Assessment of rehabilitation needs in patients after COVID-19: Development of the COVID-19-rehabilitation needs survey. J Rehabil Med. 2021; 53(4): 1-6.
  • Jang MH, Shin MJ, Shin YB. Pulmonary and physical rehabilitation in critically Ill patients. Acute Crit Care. 2019; 34(1): 1-13.
  • Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL. The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med. 2017; 43(2): 171-83.
  • Robinson J, Banerjee I, Leclezio A, Sathian B. COVID-19 and mutations a threat level assessment. Nepal J Epidemiol. 2021; 11(1): 983-7.
  • Chang D, Xu H, Rebaza A, Sharma L, Dela Cruz CS. Protecting health-care workers from subclinical coronavirus infection. Lancet Respir Med. 2020; 8(3) :e13.
  • Vilar S, Isom DG. One year of SARS-CoV-2: How much has the virus changed? biology (Basel). 2021; 10(2): 1-18.
  • Boran M, Boran OF, Korukcu O, Özkaya M. The psychological resilience and perceived stress of the frontline heroes in the pandemic in Turkey: A descriptive study of the COVID-19 outbreak-mutations-normalization triad. Jpn J Nurs Sci. 2022; 19(1): 1-11.
  • Aydemir D, Dağlıoğlu G, Candevir A, Kurtaran B, Bozdogan ST, Inal TC, et al. COVID-19 may enhance risk of thrombosis and hemolysis in the G6PD deficient patients. Nucleosides Nucleotides Nucleic Acids. 2021; 40(5): 505-17.
  • Merkies IS, van Nes SI, Hanna K, Hughes RA, Deng C. Confirming the efficacy of intravenous immunoglobulin in CIDP through minimum clinically important differences: shifting from statistical significance to clinical relevance. J Neurol Neurosurg Psychiatry. 2010; 81(11): 1194-99.
  • Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The Index of ADL: a standardızed measure of bıologıcal and psychosocıal functıon. JAMA. 1963; 185: 914-19.
  • Belgin A, Emiroğlu ON. The validity and reliability of Turkish version of Rivermead Mobility Index (RMI) in the elderly. Turk Geriatri Derg. 2007; 10(3): 124-30.
  • Bloem AEM, Veltkamp M, Spruit MA, Custers JWH, Bakker EWP, Dolk HM, et al. Validation of 4-meter-gait-speed test and 5-repetitions-sit-to-stand test in patients with pulmonary fibrosis: a clinimetric validation study. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(4): 317-26.
  • Bernabeu-Mora R, Medina-Mirapeix F, Llamazares-Herran E, Oliveira-Sousa SL, Sánchez-Martinez MP, Escolar-Reina P. The accuracy with which the 5 times sit-to-stand test, versus gait speed, can identify poor exercise tolerance in patients with COPD: A cross-sectional study. Medicine (Baltimore). 2016; 95(35): 1-6.
  • Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, et al. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil. 2010; 91(4): 536-42.
  • Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982; 14(5): 377-81.
  • Carvalho AC, Moreira J, Cubelo P, Cantista P, Branco CA, Guimaraes B. Multidisciplinary rehabilitation in intensive care for COVID-19: randomised controlled trial. ERJ Open Res. 2023; 9: 00350-2022.
  • Brower RG. Consequences of bed rest. Crit Care Med. 2009; 37(10 Suppl): 422-8.
  • Jones SE, Kon SS, Canavan JL, Patel MS, Clark AL, Nolan CM, et al. The five-repetition sit-to-stand test as a functional outcome measure in COPD. Thorax. 2013; 68(11): 1015-20.
  • Suetta C, Hvid LG, Justesen L, Christensen U, Neergaard K, Simonsen L, et al. Effects of aging on human skeletal muscle after immobilization and retraining. J Appl Physiol. 2009; 107(4): 1172-80.
  • Wiertz CMH, Vints WAJ, Maas GJCM, Rasquin SMC, van Horn YY, Dremmen MPM, et al. COVID-19: Patient characteristics in the first phase of postintensive care rehabilitation. Arch Rehabil Res Clin Transl. 2021; 3(2): 1-8.
  • Rossi V, Del Monaco C, Gambazza S, Santambrogio M, Binda F, Retucci M, et al. Time to active sitting position: One-year findings from a temporary COVID-19 intensive care unit. Respir Med. 2022; 194: 1-6.
  • Piquet V, Luczak C, Seiler F, Monaury J, Martini A, Ward AB, et al. Do patients with COVID-19 benefit from rehabilitation? functional outcomes of the first 100 patients in a COVID-19 rehabilitation unit. Arch Phys Med Rehabil. 2021; 102(6): 1067-74.
  • Rodrigues M, Costa AJ, Santos R, Diogo P, Gonçalves E, Barroso D, et al. Inpatient rehabilitation can improve functional outcomes of post-intensive care unit COVID-19 patients-a prospective study. Disabil Rehabil. 2023; 45(2): 266-76.
  • Raman B, Cassar MP, Tunnicliffe EM, Filippini N, Griffanti L, Alfaro-Almagro F, et al. Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. EClinicalMedicine. 2021; 31: 1-13.
  • Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021; 93(2): 1013-22.
  • Curci C, Negrini F, Ferrillo M, Bergonzi R, Bonacci E, Camozzi DM, et al. Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: findings and clinical implications from a real-practice retrospective study. Eur J Phys Rehabil Med. 2021; 57(3): 443-50.
  • Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009; 373(9678): 1874-82.

Effects of Short-Term Physiotherapy in Hospitalized COVID-19 Patients Infected with Mutant and Non-Mutant Virus: A Prospective Study

Yıl 2024, Cilt: 14 Sayı: 3, 343 - 350, 19.09.2024
https://doi.org/10.33631/sabd.1435647

Öz

Aim: The aim of study, to assess the short term effects of physiotherapy on patients infected with mutant and non-mutant SARS-CoV-2 virus.
Material and Methods: The patients included in the study were analyzed in two different groups. Patients infected with non-mutant SARS-CoV-2 were in Group 1 (n=16; age=53.81±9.48). Patients infected with mutant SARS-CoV-2 were included in Group 2 (n=16; age=55.25±10.12). Physiotherapy which included mobilization, normal range of motion, and a breathing exercise program, was performed on both groups (Group 1: Median=7.00; Min-Max=5-20 days; Group 2: Median: 7.00; Min-Max=4-15 days). All patients underwent a once-daily physiotherapy program. The patients' muscle strength, mobility, activities of daily living, exercise capacity, and perception of fatigue were evaluated. The mixed repeated measures ANOVA model was used to compare groups.
Results: It was found that physiotherapy improved muscle strength, mobility, ability to perform activities of daily living, exercise capacity, and perception of fatigue in both groups (p<0.05). Additionally, results for the evaluations including muscle strength (p=0.791), ADL (p=0.410), and mobility (p=0.124) were similarly favorable in both groups. There was no significant change in heart rate and SpO2 after the intervention in both group (p>0.05).
Conclusion: The current study showed that a short term physiotherapy program was as successful in patients infected with mutant SARS-CoV-2 as it was in patients infected with non-mutant SARS-CoV-2. Physiotherapy is beneficial for COVID-19 disease, as it decreases functional limitation and symptoms of COVID-19 disease by contributing positively to muscle strength, mobility, activities of daily living, exercise capacity, and the perception of fatigue.

Etik Beyan

All procedures were carried out in conformity with the Helsinki Declaration's ethical rules and principles. Ankara Bilkent City Hospital's Ethical Committee for Clinical Research provided approval dated 31.03.2021 and numbered 1644.

Destekleyen Kurum

This study did not receive financial support.

Teşekkür

The authors thank all participants who voluntarily participated in the study.

Kaynakça

  • Lopez M, Bell K, Annaswamy T, Juengst S, Ifejika N. COVID-19 guide for the rehabilitation clinician: a review of nonpulmonary manifestations and complications. Am J Phys Med Rehabil. 2020; 99(8): 669-73.
  • Park M, Cook AR, Lim JT, Sun Y, Dickens BL. A systematic review of COVID-19 epidemiology based on current evidence. J Clin Med. 2020; 9(4): 1-13.
  • Onu I, Iordan D-A, Matei D, Hrisca-Eva O-D, Buculei I, Galaction A-I, et al. Impact of physiotherapy on patients suffering from COVID-19: An observational study. Applied Sciences. 2022; 12(12): 1-13.
  • Lemhöfer C, Gutenbrunner C, Schiller J, Loudovici-Krug D, Best N, Bökel A, et al. Assessment of rehabilitation needs in patients after COVID-19: Development of the COVID-19-rehabilitation needs survey. J Rehabil Med. 2021; 53(4): 1-6.
  • Jang MH, Shin MJ, Shin YB. Pulmonary and physical rehabilitation in critically Ill patients. Acute Crit Care. 2019; 34(1): 1-13.
  • Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL. The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med. 2017; 43(2): 171-83.
  • Robinson J, Banerjee I, Leclezio A, Sathian B. COVID-19 and mutations a threat level assessment. Nepal J Epidemiol. 2021; 11(1): 983-7.
  • Chang D, Xu H, Rebaza A, Sharma L, Dela Cruz CS. Protecting health-care workers from subclinical coronavirus infection. Lancet Respir Med. 2020; 8(3) :e13.
  • Vilar S, Isom DG. One year of SARS-CoV-2: How much has the virus changed? biology (Basel). 2021; 10(2): 1-18.
  • Boran M, Boran OF, Korukcu O, Özkaya M. The psychological resilience and perceived stress of the frontline heroes in the pandemic in Turkey: A descriptive study of the COVID-19 outbreak-mutations-normalization triad. Jpn J Nurs Sci. 2022; 19(1): 1-11.
  • Aydemir D, Dağlıoğlu G, Candevir A, Kurtaran B, Bozdogan ST, Inal TC, et al. COVID-19 may enhance risk of thrombosis and hemolysis in the G6PD deficient patients. Nucleosides Nucleotides Nucleic Acids. 2021; 40(5): 505-17.
  • Merkies IS, van Nes SI, Hanna K, Hughes RA, Deng C. Confirming the efficacy of intravenous immunoglobulin in CIDP through minimum clinically important differences: shifting from statistical significance to clinical relevance. J Neurol Neurosurg Psychiatry. 2010; 81(11): 1194-99.
  • Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The Index of ADL: a standardızed measure of bıologıcal and psychosocıal functıon. JAMA. 1963; 185: 914-19.
  • Belgin A, Emiroğlu ON. The validity and reliability of Turkish version of Rivermead Mobility Index (RMI) in the elderly. Turk Geriatri Derg. 2007; 10(3): 124-30.
  • Bloem AEM, Veltkamp M, Spruit MA, Custers JWH, Bakker EWP, Dolk HM, et al. Validation of 4-meter-gait-speed test and 5-repetitions-sit-to-stand test in patients with pulmonary fibrosis: a clinimetric validation study. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(4): 317-26.
  • Bernabeu-Mora R, Medina-Mirapeix F, Llamazares-Herran E, Oliveira-Sousa SL, Sánchez-Martinez MP, Escolar-Reina P. The accuracy with which the 5 times sit-to-stand test, versus gait speed, can identify poor exercise tolerance in patients with COPD: A cross-sectional study. Medicine (Baltimore). 2016; 95(35): 1-6.
  • Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, et al. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil. 2010; 91(4): 536-42.
  • Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982; 14(5): 377-81.
  • Carvalho AC, Moreira J, Cubelo P, Cantista P, Branco CA, Guimaraes B. Multidisciplinary rehabilitation in intensive care for COVID-19: randomised controlled trial. ERJ Open Res. 2023; 9: 00350-2022.
  • Brower RG. Consequences of bed rest. Crit Care Med. 2009; 37(10 Suppl): 422-8.
  • Jones SE, Kon SS, Canavan JL, Patel MS, Clark AL, Nolan CM, et al. The five-repetition sit-to-stand test as a functional outcome measure in COPD. Thorax. 2013; 68(11): 1015-20.
  • Suetta C, Hvid LG, Justesen L, Christensen U, Neergaard K, Simonsen L, et al. Effects of aging on human skeletal muscle after immobilization and retraining. J Appl Physiol. 2009; 107(4): 1172-80.
  • Wiertz CMH, Vints WAJ, Maas GJCM, Rasquin SMC, van Horn YY, Dremmen MPM, et al. COVID-19: Patient characteristics in the first phase of postintensive care rehabilitation. Arch Rehabil Res Clin Transl. 2021; 3(2): 1-8.
  • Rossi V, Del Monaco C, Gambazza S, Santambrogio M, Binda F, Retucci M, et al. Time to active sitting position: One-year findings from a temporary COVID-19 intensive care unit. Respir Med. 2022; 194: 1-6.
  • Piquet V, Luczak C, Seiler F, Monaury J, Martini A, Ward AB, et al. Do patients with COVID-19 benefit from rehabilitation? functional outcomes of the first 100 patients in a COVID-19 rehabilitation unit. Arch Phys Med Rehabil. 2021; 102(6): 1067-74.
  • Rodrigues M, Costa AJ, Santos R, Diogo P, Gonçalves E, Barroso D, et al. Inpatient rehabilitation can improve functional outcomes of post-intensive care unit COVID-19 patients-a prospective study. Disabil Rehabil. 2023; 45(2): 266-76.
  • Raman B, Cassar MP, Tunnicliffe EM, Filippini N, Griffanti L, Alfaro-Almagro F, et al. Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. EClinicalMedicine. 2021; 31: 1-13.
  • Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021; 93(2): 1013-22.
  • Curci C, Negrini F, Ferrillo M, Bergonzi R, Bonacci E, Camozzi DM, et al. Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: findings and clinical implications from a real-practice retrospective study. Eur J Phys Rehabil Med. 2021; 57(3): 443-50.
  • Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009; 373(9678): 1874-82.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Egzersiz ve Spor Bilimleri (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Ülkü Kezban Şahin 0000-0001-8972-4774

Neyzar Kılınç 0000-0003-4855-5411

Habibe Durdu 0000-0003-0716-1109

Enes Seyda Şahiner 0000-0003-4552-0387

Yayımlanma Tarihi 19 Eylül 2024
Gönderilme Tarihi 12 Şubat 2024
Kabul Tarihi 14 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 14 Sayı: 3

Kaynak Göster

Vancouver Şahin ÜK, Kılınç N, Durdu H, Şahiner ES. Effects of Short-Term Physiotherapy in Hospitalized COVID-19 Patients Infected with Mutant and Non-Mutant Virus: A Prospective Study. SABD. 2024;14(3):343-50.