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Üçüncü Trimesterde Vajinal Kanama Şikâyetiyle Acil Servise Başvuran Gebelerde Klinik Sonuçların 10 Yıllık Retrospektif Analizi

Yıl 2025, Cilt: 15 Sayı: 3, 448 - 454, 24.09.2025
https://doi.org/10.33631/sabd.1745623

Öz

Amaç: Bu çalışma, üçüncü trimesterde vajinal kanama şikâyetiyle acil servise başvuran gebelerin klinik özelliklerini ve sonuçlarını değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntemler: Bu retrospektif, gözlemsel çalışmaya, Ocak 2013–Aralık 2023 tarihleri arasında ≥28. gebelik haftasında olup vajinal kanama nedeniyle acil servise başvuran gebeler dahil edildi. Demografik veriler, parite, gebelik haftası, başvuru zamanı, kanama şiddeti, vital bulgular, laboratuvar sonuçları ve klinik sonuçlar (doğum, yatış, taburculuk, düşük riski) analiz edildi.
Bulgular: Çalışmaya toplam 1263 gebe dahil edildi. En sık başvuru nedeni %49,9 ile lekelenme tarzı kanama, ikinci sırada ise %46,8 ile aktif vajinal kanama yer aldı. Tüm hastaların %33,7’si hastaneye yatırıldı, %12,9’u doğum yaptı, %15,1’i düşük riski olarak değerlendirildi. Kanama şiddeti arttıkça doğum ve düşük riski oranları anlamlı şekilde yükseldi (p<0,001). Gece saatlerinde (00:00–05:59) doğum oranları daha yüksek bulunurken, akşam başvurularında (18:00–23:59) düşük riski en fazla görüldü. Parite ile sonuçlar arasında anlamlı ilişki saptandı; multipar hastalarda doğum oranı daha yüksekken (%10,7 vs. %5,8), primipar hastalarda düşük riski daha yüksekti (%59,3 vs. %44,0; OR=1,89, %95 GA: 1,45–2,47, p<0,001).
Sonuç: Üçüncü trimester vajinal kanamaları, kanama şiddeti, başvuru zamanı ve pariteye göre değişken klinik sonuçlar doğurabilen önemli obstetrik acillerdir. Acil tıp ve kadın doğum hekimlerinin bu risk desenlerini tanıması ve multidisipliner iş birliği içinde hareket etmesi gerekmektedir. Kanıta dayalı protokollerin geliştirilmesi, bu yüksek riskli grupta maternal ve fetal sonuçları iyileştirebilir.

Kaynakça

  • Cunningham JW. Prompt evaluation and treatment of third-trimester bleeding. JAAPA. 2021;34(1):26-31.
  • Bosilah AH, Eldesouky E, Alghazaly MM, Farag E, Sultan EEK, Alazazy H, et al. Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy. BMC Pregnancy Childbirth. 2023;23(1):433.
  • Kabiri D, Amsalem H, Watad H, Lipschuetz M, Haj-Yahya R, Alter R, et al. Assessing the clinical significance of third-trimester post-coital bleeding. Fetal Diagn Ther. 2024;51(2):168-74.
  • Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F et al. Outcome of Cesarean scar pregnancy managed expectantly: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51(2):169-75.
  • Tyson DP, Kelleher KJ, Chavez LJ. Mental Health-related utilization of emergency departments during pregnancy in the U.S., 2016-2019. Matern Child Health J. 2022;26(10):1953-8.
  • Chen D, Gao X, Yang T, Xin X, Wang G, Wang H, et al. Independent risk factors for placental abruption: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2025;25(1):351.
  • Nissen M, Barrios Campo N, Flaucher M, Jaeger KM, Titzmann A, Blunck D, et al. Prevalence and course of pregnancy symptoms using self-reported pregnancy app symptom tracker data. NPJ Digit Med. 2023;6(1):189.
  • Burgoyne MM, Clouston R, Banerjee A, Chandra K, Fraser J, Lewis D, et al. Variables associated with favorable obstetrical outcomes in early pregnancy bleeding in the emergency department. Cureus. 2024;16(10):e70986.
  • Matar M, Yared G, Massaad C, Ghazal K. Vaginal bleeding during pregnancy: a retrospective cohort study assessing maternal and perinatal outcomes. J Int Med Res. 2025;53(2):3000605251315349.
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806-8.
  • Varner C, Balaban D, McLeod S, Carver S, Borgundvaag B. Fetal outcomes following emergency department point-of-care ultrasound for vaginal bleeding in early pregnancy. Can Fam Physician. 2016;62(7):572-8.
  • Lee SU, Jo JH, Lee H, Na Y, Park IY. A multicenter, retrospective comparison study of pregnancy outcomes according to placental location in placenta previa. J Clin Med. 2024;13(3):675.
  • Xiao H, Xing X, Zhang C, Shao Y. Association between clinical subtypes and pregnancy outcome of cervical incompetence: a retrospective cohort study. BMC Pregnancy Childbirth. 2025;25(1):348.
  • Essel NOM, Couperthwaite S, Yang EH, Fisher S, Rowe BH. Patients presenting to the emergency department with bleeding in early pregnancy: comparing different models to predict pregnancy success. JOGC. 2025;47(4):102789.
  • Strommen J, Masullo L, Crowell T, Moffett P. First-trimester vaginal bleeding: patient expectations when presenting to the emergency department. Mil Med. 2017;182(11):e1824-e6.
  • Muñoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, et al. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019;17(2):112-36.
  • Matenchuk BA, Rosychuk RJ, Rowe BH, Metcalfe A, Chari R, Crawford S, et al. Emergency department visits during pregnancy. Ann Emerg Med. 2023;81(2):197-208.
  • Çakmak BD, Türker ÜA, Dündar B, Yumru AE. The retrospective analysis of abruptio placenta cases in a tertiary center: risk factors and perinatal outcomes. Haydarpasa Numune Med J. 2019;59:88-94.
  • Downes KL, Grantz KL, Shenassa ED. Maternal, labor, delivery, and perinatal outcomes associated with placental abruption. A systematic review. Am J Perinatol. 2017;34(10):935-57.
  • Businge J, Turanzomwe S, Akol MA, Kakama C, Kajabwangu R, Kanyesigye M, et al. Decision to delivery interval and predictors for delayed decision to delivery interval among women delivering by emergency caesarean section at a tertiary hospital, Southwestern Uganda: a prospective cohort study. BMC Pregnancy Childbirth. 2025;25(1):546.
  • Teberik C, Keyif B, Göynümer FG, Başbuğ A, Yurtçu E. Predictive value of intrapartum transperineal ultrasonography in determining delivery mode: a prospective study. Konuralp Med J. 2025;17(2):189-95.
  • Yared G, Madi N, Barakat H, El Hajjar C, Al Hassan J, Nakib H, et al. Uterine sacrifice in obstetric emergencies case series: complex cases of fetal distress, labor challenges, and life-saving interventions. SAGE Open Med Case Rep. 2024;12:2050313x241261487.
  • Kovalak EE, Akgül ÖK, Aksoy NK, Hayirlioğlu N, Kaya E. The Relationship between the number of miscarriages and diagnostic parameters in couples with recurrent pregnancy loss: a retrospective cohort study. J Clin Obstet Gynecol. 2023;33(3):143-50.
  • Peled T, Weiss A, Hochler H, Sela HY, Lipschuetz M, Karavani G, et al. Perinatal outcomes in grand multiparous women stratified by parity- A large multicenter study. Eur J Obstet Gynecol Reprod Biol. 2024;300:164-70.
  • Lin Me, Li L. Clinical efficacy and prognostic factors of mcdonald cervical cerclage in pregnant women with cervical incompetence. Clin Exp Obstet Gynecol. 2024;51(11):247.

Clinical Outcomes of Third Trimester Pregnant Women Presenting to the Emergency Department with Vaginal Bleeding: A 10-Year Retrospective Analysis

Yıl 2025, Cilt: 15 Sayı: 3, 448 - 454, 24.09.2025
https://doi.org/10.33631/sabd.1745623

Öz

Aim: This study aimed to evaluate the clinical characteristics and outcomes pregnant women in the third trimester presenting to the emergency department with vaginal bleeding.
Material and Methods: This retrospective, observational study included pregnant women at ≥28 weeks of gestation who presented to the ED with vaginal bleeding between January 2013 and December 2023. Demographic characteristics, parity, gestational age, timing of admission, bleeding severity, initial vital signs, laboratory results, and clinical outcomes (delivery, admission, discharge, miscarriage risk) were analyzed.
Results: A total of 1263 pregnant women were included. The most frequent complaints were spotting (49.9%) and active vaginal bleeding (46.8%), accounting for over 96% of all visits. Of all patients, 33.7% were hospitalized, 12.9% delivered, and 15.1% were categorized as miscarriage risk. Heavier bleeding was significantly associated with both delivery and miscarriage risk (p<0.001). Deliveries occurred more frequently at night (00:00–05:59), while miscarriage risk peaked during evening admissions (18:00–23:59). Parity was significantly associated with outcomes: multiparous women were more likely to deliver (10.7% vs. 5.8%), whereas primiparous women had higher miscarriage risk (59.3% vs. 44.0%; OR=1.89, 95% CI: 1.45–2.47, p<0.001).
Conclusion: Third-trimester vaginal bleeding is a complex emergency with variable outcomes depending on bleeding severity, timing of presentation, and parity. Emergency physicians and obstetricians should recognize these risk patterns and collaborate closely in managing such cases. Development of evidence-based protocols may improve maternal and fetal outcomes in this high-risk population.

Kaynakça

  • Cunningham JW. Prompt evaluation and treatment of third-trimester bleeding. JAAPA. 2021;34(1):26-31.
  • Bosilah AH, Eldesouky E, Alghazaly MM, Farag E, Sultan EEK, Alazazy H, et al. Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy. BMC Pregnancy Childbirth. 2023;23(1):433.
  • Kabiri D, Amsalem H, Watad H, Lipschuetz M, Haj-Yahya R, Alter R, et al. Assessing the clinical significance of third-trimester post-coital bleeding. Fetal Diagn Ther. 2024;51(2):168-74.
  • Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F et al. Outcome of Cesarean scar pregnancy managed expectantly: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51(2):169-75.
  • Tyson DP, Kelleher KJ, Chavez LJ. Mental Health-related utilization of emergency departments during pregnancy in the U.S., 2016-2019. Matern Child Health J. 2022;26(10):1953-8.
  • Chen D, Gao X, Yang T, Xin X, Wang G, Wang H, et al. Independent risk factors for placental abruption: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2025;25(1):351.
  • Nissen M, Barrios Campo N, Flaucher M, Jaeger KM, Titzmann A, Blunck D, et al. Prevalence and course of pregnancy symptoms using self-reported pregnancy app symptom tracker data. NPJ Digit Med. 2023;6(1):189.
  • Burgoyne MM, Clouston R, Banerjee A, Chandra K, Fraser J, Lewis D, et al. Variables associated with favorable obstetrical outcomes in early pregnancy bleeding in the emergency department. Cureus. 2024;16(10):e70986.
  • Matar M, Yared G, Massaad C, Ghazal K. Vaginal bleeding during pregnancy: a retrospective cohort study assessing maternal and perinatal outcomes. J Int Med Res. 2025;53(2):3000605251315349.
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806-8.
  • Varner C, Balaban D, McLeod S, Carver S, Borgundvaag B. Fetal outcomes following emergency department point-of-care ultrasound for vaginal bleeding in early pregnancy. Can Fam Physician. 2016;62(7):572-8.
  • Lee SU, Jo JH, Lee H, Na Y, Park IY. A multicenter, retrospective comparison study of pregnancy outcomes according to placental location in placenta previa. J Clin Med. 2024;13(3):675.
  • Xiao H, Xing X, Zhang C, Shao Y. Association between clinical subtypes and pregnancy outcome of cervical incompetence: a retrospective cohort study. BMC Pregnancy Childbirth. 2025;25(1):348.
  • Essel NOM, Couperthwaite S, Yang EH, Fisher S, Rowe BH. Patients presenting to the emergency department with bleeding in early pregnancy: comparing different models to predict pregnancy success. JOGC. 2025;47(4):102789.
  • Strommen J, Masullo L, Crowell T, Moffett P. First-trimester vaginal bleeding: patient expectations when presenting to the emergency department. Mil Med. 2017;182(11):e1824-e6.
  • Muñoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, et al. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019;17(2):112-36.
  • Matenchuk BA, Rosychuk RJ, Rowe BH, Metcalfe A, Chari R, Crawford S, et al. Emergency department visits during pregnancy. Ann Emerg Med. 2023;81(2):197-208.
  • Çakmak BD, Türker ÜA, Dündar B, Yumru AE. The retrospective analysis of abruptio placenta cases in a tertiary center: risk factors and perinatal outcomes. Haydarpasa Numune Med J. 2019;59:88-94.
  • Downes KL, Grantz KL, Shenassa ED. Maternal, labor, delivery, and perinatal outcomes associated with placental abruption. A systematic review. Am J Perinatol. 2017;34(10):935-57.
  • Businge J, Turanzomwe S, Akol MA, Kakama C, Kajabwangu R, Kanyesigye M, et al. Decision to delivery interval and predictors for delayed decision to delivery interval among women delivering by emergency caesarean section at a tertiary hospital, Southwestern Uganda: a prospective cohort study. BMC Pregnancy Childbirth. 2025;25(1):546.
  • Teberik C, Keyif B, Göynümer FG, Başbuğ A, Yurtçu E. Predictive value of intrapartum transperineal ultrasonography in determining delivery mode: a prospective study. Konuralp Med J. 2025;17(2):189-95.
  • Yared G, Madi N, Barakat H, El Hajjar C, Al Hassan J, Nakib H, et al. Uterine sacrifice in obstetric emergencies case series: complex cases of fetal distress, labor challenges, and life-saving interventions. SAGE Open Med Case Rep. 2024;12:2050313x241261487.
  • Kovalak EE, Akgül ÖK, Aksoy NK, Hayirlioğlu N, Kaya E. The Relationship between the number of miscarriages and diagnostic parameters in couples with recurrent pregnancy loss: a retrospective cohort study. J Clin Obstet Gynecol. 2023;33(3):143-50.
  • Peled T, Weiss A, Hochler H, Sela HY, Lipschuetz M, Karavani G, et al. Perinatal outcomes in grand multiparous women stratified by parity- A large multicenter study. Eur J Obstet Gynecol Reprod Biol. 2024;300:164-70.
  • Lin Me, Li L. Clinical efficacy and prognostic factors of mcdonald cervical cerclage in pregnant women with cervical incompetence. Clin Exp Obstet Gynecol. 2024;51(11):247.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Betül Keyif 0000-0002-8521-5486

Engin Yurtçu 0000-0002-1517-3823

Toprak Mustafa Öztürk 0000-0001-7958-7921

Metehan Özen 0009-0001-1626-230X

Sahra Merve Yıldız 0009-0001-1389-1389

Mustafa Boğan 0000-0002-3238-1827

Yayımlanma Tarihi 24 Eylül 2025
Gönderilme Tarihi 18 Temmuz 2025
Kabul Tarihi 22 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 15 Sayı: 3

Kaynak Göster

Vancouver Keyif B, Yurtçu E, Öztürk TM, Özen M, Yıldız SM, Boğan M. Clinical Outcomes of Third Trimester Pregnant Women Presenting to the Emergency Department with Vaginal Bleeding: A 10-Year Retrospective Analysis. SABD. 2025;15(3):448-54.