Yıl 2019, Cilt 2 , Sayı 3, Sayfalar 115 - 125 2019-12-30

Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi
The Importance of Long Noncoding RNAs in Cardiovascular Diseases

Hilal ŞENTÜRK [1] , Evrim KOMURCU-BAYRAK [2]


Kardiyovasküler hastalıklar (KVH'lar), mortalite ve morbiditenin en önemli nedeni olup çoğunlukla yetişkinlerde gözlenmektedir. KVH’ların altında yatan ana mekanizma, fibröz plakların oluşumu, düz kas hücrelerinin çoğalması ve enflamatuvar hücrelerin göçü ile meydana gelen karmaşık bir patoloji olan aterosklerozdur. Son çalışmalar, uzun kodlamayan RNA'lar (lncRNA) ve dairesel RNA'lar (circRNA) gibi protein kodlamayan RNA'ların, ateroskleroz dahil tüm KVH’ların epigenetiğinde önemli düzenleyici rollere sahip olduğunu göstermektedir. Bu derlemede, lncRNA'ların ve circRNA'ların fonksiyonel aktiviteleri ve bunların ateroskleroz ve KVH’larla olan ilişkileri özetlenmektedir.

Cardiovascular diseases (CVDs) are a leading cause of mortality and morbidity and mostly affect adults. The main underlying mechanism of CVDs is atherosclerosis and this complex pathology is caused by the formation of fibrous plaques, the proliferation of smooth muscle cells and the migration of inflammatory cells. Recent studies suggest that noncoding RNAs such as long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have critical regulatory roles in the epigenetics of all CVDs including atherosclerosis. This review summarizes the functional roles of lncRNAs and circRNAs and their relationships with atherosclerosis and CVDs. 

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Yazarlar

Orcid: 0000-0001-9743-5817
Yazar: Hilal ŞENTÜRK
Kurum: İSTANBUL ÜNİVERSİTESİ, AZİZ SANCAR DENEYSEL TIP ARAŞTIRMA ENSTİTÜSÜ, GENETİK ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0003-1271-1208
Yazar: Evrim KOMURCU-BAYRAK (Sorumlu Yazar)
Kurum: İSTANBUL ÜNİVERSİTESİ, AZİZ SANCAR DENEYSEL TIP ARAŞTIRMA ENSTİTÜSÜ, GENETİK ANABİLİM DALI
Ülke: Turkey


Destekleyen Kurum İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi
Proje Numarası TYL-2017-27636
Tarihler

Yayımlanma Tarihi : 30 Aralık 2019

APA ŞENTÜRK, H , KOMURCU-BAYRAK, E . (2019). Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi. Sağlık Bilimlerinde İleri Araştırmalar Dergisi , 2 (3) , 115-125 . DOI: 10.26650/JARHS2019-638138