MOLECULAR BIOLOGY AND GENETIC STUDIES IN COMBATING THE NEW CORONAVIRUS (COVID-19) OUTBREAK

Yıl 2022, Cilt: 5 Sayı: 1, 41 - 49, 10.02.2022

Pervin Elvan Tokgün Sude Dedeoğlu Ayşe Gaye Tomatır

https://doi.org/10.26650/JARHS2022-946582

Öz

The new type of coronavirus (SARS-CoV-2), which is transmitted from person to person and causes Severe Acute Respiratory Distress Syndrome (SARS), emerged in Wuhan, China in December 2019. The definitive diagnosis of the coronavirus, which is transmitted from person to person through droplets, is given through PCR-based tests. The continuation of the COVID-19 pandemic has made it necessary to develop an effective vaccine against SARS-CoV-2. Vaccines developed against COVID-19 can be classified as inactivated/live virus vaccines, recombinant protein vaccines/ vectored vaccines or RNA/DNA vaccines. This review aims to give information about the molecular structure and genetic features of SARSCoV- 2 virus, laboratory diagnostic methods, potential therapeutic drugs and vaccine studies.

Anahtar Kelimeler

SARS-COV-2, Molecular genetics methods, COVID-19 treatment, Vaccine strategies

YENİ KORONAVİRÜS (COVİD-19) SALGINIYLA MÜCADELEDE MOLEKÜLER BİYOLOJİ VE GENETİK ÇALIŞMALARI

Öz

İnsandan insana bulaşan ve Ağır Akut Solunum Yetmezliği Sendromuna (SARS) neden olan yeni tip koronavirüs (SARS-CoV-2) 2019 yılı Aralık ayında Çin’in Wuhan şehrinde ortaya çıkmıştır. Damlacıklar yoluyla insandan insana bulaşan koronavirüsün kesin tanısı PZR tabanlı testler ile verilmektedir. COVID-19 pandemisinin devam etmesi SARS-CoV-2 ‘ye karşı etkili bir aşı geliştirmenin gerekliliği ortaya çıkmıştır. COVID-19’a karşı geliştirilen aşılar inaktive edilmiş / canlı virüs aşıları, rekombinant protein aşıları / vektörlü aşılar ve RNA/ DNA aşıları olarak sınıflandırılabilir. Bu derlemede SARS-CoV-2 virüsünün moleküler yapısı ve genetik özellikleri, laboratuvar teşhis metotları, potansiyel terapötik ilaçlar ve aşı çalışmaları hakkında bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

SARS-COV-2, Moleküler Genetik yöntemler, COVİD-19 Tedavisi, Aşı Çalışmaları

Kaynakça

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