Obezite Tedavisinde Diyete Eklenen Ozon Terapinin Etkisi

Öz

ÖZ Amaç: Bu çalışma, obezite tedavisinde önerilen zayıflama diyeti ve ozon tedavisi uygulamasının ağırlık kaybı ve lipid ve karbonhidrat metabolizmasıyla ilişkili biyokimyasal parametreler üzerine etkilerini incelemek amaçlanmıştır. Gereç ve Yöntem: Etik kurul onayı alınan bu çalışma, İstanbul'daki bir Eğitim ve Araştırma Hastanesi'ne başvuran kırk obez hasta ile yürütülmüştür. Hastalar iki gruba ayrılarak bir ay boyunca diyet tedavisi uygulanmıştır. Bir gruba, diğer gruptan farklı olarak, sabah aç karnına tüketilmek üzere ozon kapsülü verilmiştir. Tedavinin etkinliği, hastaların başlangıçta ve bir ay sonra antropometrik ölçümleri ve biyokimyasal değerleri alınarak incelenmiştir. Sonuçlar: Diyet ve Diyet+Ozon grubunda başlangıçta ve bir ay sonunda vücut ağırlığı, beden kütle indeksi, bel çevresi, VLDL kolesterol ve trigliserid değerlerinde anlamlı bir azalma görülmüştür (her biri için p<0,01). Sadece diyet grubunda, ilk ayın sonunda başlangıç LDL kolesterol değerlerinde anlamlı bir düşüş gözlenmiştir (p<0,01). Sonuç: Sonuç olarak, Diyet ve Diyet+Ozon grubunda kilo, BKİ, yağ yüzdesi, bel çevresi, kalça çevresi, toplam kolesterol ve LDL ölçümlerinde anlamlı bir düşüş olduğu, ozon tedavisi grubunda ise değişimin daha fazla olduğu bulunmuştur. KAYNAKÇA Chandrasekaran, P., & Weiskirchen, R. (2024). The role of obesity in type 2 diabetes mellitus—An overview. International journal of molecular sciences, 25(3), 1882. Ciborowski, M., Lipska, A., Godzien, J., Ferrarini, A., Korsak, J., Radziwon, P., Tomasiak, M., & Barbas, C. (2012). Combination of LC–MS-and GC–MS-based metabolomics to study the effect of ozonated autohemotherapy on human blood. Journal of proteome research, 11(12), 6231-6241. Hernández, F., Menéndez, S., & Wong, R. (1995). Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radical Biology and Medicine, 19(1), 115-119. Kesikburun, S., & Yaşar, E. (2017). Ozon tedavisi. Totbid Dergisi, 16, 196-202. Kızıltan, G., & Saka, M. (Eds.). (2018). Bariatrik Cerrahi ve Beslenme. Türkiye Diyetisyenler Derneği. Kiziltan, H. S., Bayir, A. G., Yucesan, G., Eris, A. H., İdin, K., Karatoprak, C., Aydin, T., Akcakaya, A., & Mayadagli, A. (2015). Medical ozone and radiotherapy in a peritoneal, Erlich-ascites, tumor-cell model. Altern Ther Health Med, 21(2), 24-29. Lu, J., Ding, S., Tang, Z., Tong, X., Dou, J., Gao, L., & Zeng, J. (2020). Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis. 1-16. Martínez-Sánchez, G., Al-Dalain, S. M., Menéndez, S., Re, L., Giuliani, A., Candelario-Jalil, E., Álvarez, H., Fernández-Montequín, J. I., & León, O. S. (2005). Therapeutic efficacy of ozone in patients with diabetic foot. European journal of pharmacology, 523(1-3), 151-161. Moreno-Fernández, A., Macías-García, L., Valverde-Moreno, R., Ortiz, T., Fernández-Rodríguez, A., Moliní-Estrada, A., & De-Miguel, M. (2019). Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta reumatologica portuguesa, 44(3), 244-249. Morsy, M. D., Hassan, W. N., & Zalat, S. I. (2010). Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats. Diabetology & metabolic syndrome, 2(1), 29. Özdogan, E., Özdogan, O., Altunoglu, E. G., & Köksal, A. R. (2015). Tip 2 diyabet hastalarinda kan lipid düzeylerinin hba1c ve obezite ile iliskisi. Şişli Etfal Hastanesi Tip Bülteni, 49(4), 248. Rapone, B., Ferrara, E., Corsalini, M., Converti, I., Grassi, F. R., Santacroce, L., Topi, S., Gnoni, A., Scacco, S., & Scarano, A. (2020). The effect of gaseous ozone therapy in conjunction with periodontal treatment on glycated hemoglobin level in subjects with type 2 diabetes mellitus: An unmasked randomized controlled trial. International journal of environmental research and public health, 17(15), 5467. Rezaeianjam, M., Khabazian, A., Khabazian, T., Ghorbani, F., Abbasi, T., Asghari, S., Heidari, F., Shiri, A., & Naderi, M. (2025). Efficacy of ozone therapy in dentistry with approach of healing, pain management, and therapeutic outcomes: a systematic review of clinical trials. BMC Oral Health, 25(1), 433. Sherov, U. (2022). Efficacy of metformin in combination ozone therapy in children and adolescents with metabolic syndrome. Central asian journal of theoretical and applied sciences, 03(10), 256-259. Sroczynski, J., Grzeszczak, W., & Rudzki, H. (1994). Effects of intravenous ozone application on some parameters of lipid metabolism in experimental atherosclerosis in rabitts. Ann Acad Med Siles, 17(Suppl), 65-72. Sundbom, M., Järvholm, K., Sjögren, L., Nowicka, P., & Lagerros, Y. T. (2024). Obesity treatment in adolescents and adults in the era of personalized medicine. Journal of internal medicine, 296(2), 139-155. Tapia, A. S., & Sánchez, G. M. (2012). La ozonoterapia y su fundamentación científica. Revista Española de Ozonoterapia, 2(1), 163-198. Tseveenmyadag, M. M., Khurelbaatar, S. M., & Tseveenmyadag, M. (2018). Some results of the outcome after ozone therapy diagnosed with diabetes. Биорадикалы и антиоксиданты, 5(3), 102-102. Tylicki, L., Biedunkiewicz, B., Nieweglowski, T., Chamienia, A., Slizien, A. D., Luty, J., Lysiak‐Szydlowska, W., & Rutkowski, B. (2004). Ozonated autohemotherapy in patients on maintenance hemodialysis: influence on lipid profile and endothelium. Artificial organs, 28(2), 234-237. Ugazio, E., Tullio, V., Binello, A., Tagliapietra, S., & Dosio, F. (2020). Ozonated oils as antimicrobial systems in topical applications. Their characterization, current applications, and advances in improved delivery techniques. Molecules, 25(2), 334. Xie, T., Yan, W., Lou, J., & Chen, X. (2016). Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy. Genet Mol Res, 15(2), 1-11.

Anahtar Kelimeler

• Ağırlık Kaybı
• Dislipidemi
• Diyet
• Obezite
• Ozon Tedavisi

Effect of Ozone Therapy Added to the Diet in the Treatment of Obesity

Öz

ABSTRACT Aim: This study aimed to investigate the effects of the recommended weight loss diet and ozone therapy in the treatment of obesity on biochemical parameters related to weight loss and lipid and carbohydrate metabolism. Materials and Methods: With the approval of the ethics committee, it was carried out with 40 obese patients who applied to a Training and Research Hospital in Istanbul with weight problems. Diet therapy was applied for one month to the patients divided into two groups. One group, unlike the other, was given an ozone capsule to be consumed in the morning on an empty stomach. The effectiveness of the treatment was examined taking biochemical values and anthropometric measurements of the patients at the baseline and after one month. Results: There was a significant decrease in weight, body mass index, waist circumference, VLDL cholesterol and triglyceride values in the Diet and Diet+Ozone group at the baseline and at the end of one month (p<0.01 for each). A significant decrease was observed in the initial LDL cholesterol values only in the diet group at the end of the first month (p<0.01). Conclusion: As a result, it was found that there was a significant decrease in body weight, BMI, fat percentage, waist circumference, hip circumference, total cholesterol and LDL measurements in the Diet and Diet+Ozone group, while the change was slightly higher in the ozone therapy group. REFERENCES Chandrasekaran, P., & Weiskirchen, R. (2024). The role of obesity in type 2 diabetes mellitus—An overview. International journal of molecular sciences, 25(3), 1882. Ciborowski, M., Lipska, A., Godzien, J., Ferrarini, A., Korsak, J., Radziwon, P., Tomasiak, M., & Barbas, C. (2012). Combination of LC–MS-and GC–MS-based metabolomics to study the effect of ozonated autohemotherapy on human blood. Journal of proteome research, 11(12), 6231-6241. Hernández, F., Menéndez, S., & Wong, R. (1995). Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radical Biology and Medicine, 19(1), 115-119. Kesikburun, S., & Yaşar, E. (2017). Ozon tedavisi. Totbid Dergisi, 16, 196-202. Kızıltan, G., & Saka, M. (Eds.). (2018). Bariatrik Cerrahi ve Beslenme. Türkiye Diyetisyenler Derneği. Kiziltan, H. S., Bayir, A. G., Yucesan, G., Eris, A. H., İdin, K., Karatoprak, C., Aydin, T., Akcakaya, A., & Mayadagli, A. (2015). Medical ozone and radiotherapy in a peritoneal, Erlich-ascites, tumor-cell model. Altern Ther Health Med, 21(2), 24-29. Lu, J., Ding, S., Tang, Z., Tong, X., Dou, J., Gao, L., & Zeng, J. (2020). Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis. 1-16. Martínez-Sánchez, G., Al-Dalain, S. M., Menéndez, S., Re, L., Giuliani, A., Candelario-Jalil, E., Álvarez, H., Fernández-Montequín, J. I., & León, O. S. (2005). Therapeutic efficacy of ozone in patients with diabetic foot. European journal of pharmacology, 523(1-3), 151-161. Moreno-Fernández, A., Macías-García, L., Valverde-Moreno, R., Ortiz, T., Fernández-Rodríguez, A., Moliní-Estrada, A., & De-Miguel, M. (2019). Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta reumatologica portuguesa, 44(3), 244-249. Morsy, M. D., Hassan, W. N., & Zalat, S. I. (2010). Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats. Diabetology & metabolic syndrome, 2(1), 29. Özdogan, E., Özdogan, O., Altunoglu, E. G., & Köksal, A. R. (2015). Tip 2 diyabet hastalarinda kan lipid düzeylerinin hba1c ve obezite ile iliskisi. Şişli Etfal Hastanesi Tip Bülteni, 49(4), 248. Rapone, B., Ferrara, E., Corsalini, M., Converti, I., Grassi, F. R., Santacroce, L., Topi, S., Gnoni, A., Scacco, S., & Scarano, A. (2020). The effect of gaseous ozone therapy in conjunction with periodontal treatment on glycated hemoglobin level in subjects with type 2 diabetes mellitus: An unmasked randomized controlled trial. International journal of environmental research and public health, 17(15), 5467. Rezaeianjam, M., Khabazian, A., Khabazian, T., Ghorbani, F., Abbasi, T., Asghari, S., Heidari, F., Shiri, A., & Naderi, M. (2025). Efficacy of ozone therapy in dentistry with approach of healing, pain management, and therapeutic outcomes: a systematic review of clinical trials. BMC Oral Health, 25(1), 433. Sherov, U. (2022). Efficacy of metformin in combination ozone therapy in children and adolescents with metabolic syndrome. Central asian journal of theoretical and applied sciences, 03(10), 256-259. Sroczynski, J., Grzeszczak, W., & Rudzki, H. (1994). Effects of intravenous ozone application on some parameters of lipid metabolism in experimental atherosclerosis in rabitts. Ann Acad Med Siles, 17(Suppl), 65-72. Sundbom, M., Järvholm, K., Sjögren, L., Nowicka, P., & Lagerros, Y. T. (2024). Obesity treatment in adolescents and adults in the era of personalized medicine. Journal of internal medicine, 296(2), 139-155. Tapia, A. S., & Sánchez, G. M. (2012). La ozonoterapia y su fundamentación científica. Revista Española de Ozonoterapia, 2(1), 163-198. Tseveenmyadag, M. M., Khurelbaatar, S. M., & Tseveenmyadag, M. (2018). Some results of the outcome after ozone therapy diagnosed with diabetes. Биорадикалы и антиоксиданты, 5(3), 102-102. Tylicki, L., Biedunkiewicz, B., Nieweglowski, T., Chamienia, A., Slizien, A. D., Luty, J., Lysiak‐Szydlowska, W., & Rutkowski, B. (2004). Ozonated autohemotherapy in patients on maintenance hemodialysis: influence on lipid profile and endothelium. Artificial organs, 28(2), 234-237. Ugazio, E., Tullio, V., Binello, A., Tagliapietra, S., & Dosio, F. (2020). Ozonated oils as antimicrobial systems in topical applications. Their characterization, current applications, and advances in improved delivery techniques. Molecules, 25(2), 334. Xie, T., Yan, W., Lou, J., & Chen, X. (2016). Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy. Genet Mol Res, 15(2), 1-11.

Anahtar Kelimeler

• Diet
• Dyslipidaemia
• Obesity
• Ozone Therapy
• Weight Loss

Kaynakça

1. Chandrasekaran, P., & Weiskirchen, R. (2024). The role of obesity in type 2 diabetes mellitus—An overview. International journal of molecular sciences, 25(3), 1882.
2. Ciborowski, M., Lipska, A., Godzien, J., Ferrarini, A., Korsak, J., Radziwon, P., Tomasiak, M., & Barbas, C. (2012). Combination of LC–MS-and GC–MS-based metabolomics to study the effect of ozonated autohemotherapy on human blood. Journal of proteome research, 11(12), 6231-6241.
3. Hernández, F., Menéndez, S., & Wong, R. (1995). Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radical Biology and Medicine, 19(1), 115-119.
4. Kesikburun, S., & Yaşar, E. (2017). Ozon tedavisi. Totbid Dergisi, 16, 196-202.
5. Kızıltan, G., & Saka, M. (Eds.). (2018). Bariatrik Cerrahi ve Beslenme. Türkiye Diyetisyenler Derneği.
6. Kiziltan, H. S., Bayir, A. G., Yucesan, G., Eris, A. H., İdin, K., Karatoprak, C., Aydin, T., Akcakaya, A., & Mayadagli, A. (2015). Medical ozone and radiotherapy in a peritoneal, Erlich-ascites, tumor-cell model. Altern Ther Health Med, 21(2), 24-29.
7. Lu, J., Ding, S., Tang, Z., Tong, X., Dou, J., Gao, L., & Zeng, J. (2020). Ozone autohemotherapy elevates PPAR-γ expression to lower blood lipid in treatment for psoriasis. 1-16.
8. Martínez-Sánchez, G., Al-Dalain, S. M., Menéndez, S., Re, L., Giuliani, A., Candelario-Jalil, E., Álvarez, H., Fernández-Montequín, J. I., & León, O. S. (2005). Therapeutic efficacy of ozone in patients with diabetic foot. European journal of pharmacology, 523(1-3), 151-161.

9. Moreno-Fernández, A., Macías-García, L., Valverde-Moreno, R., Ortiz, T., Fernández-Rodríguez, A., Moliní-Estrada, A., & De-Miguel, M. (2019). Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta reumatologica portuguesa, 44(3), 244-249.
10. Morsy, M. D., Hassan, W. N., & Zalat, S. I. (2010). Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats. Diabetology & metabolic syndrome, 2(1), 29.
11. Özdogan, E., Özdogan, O., Altunoglu, E. G., & Köksal, A. R. (2015). Tip 2 diyabet hastalarinda kan lipid düzeylerinin hba1c ve obezite ile iliskisi. Şişli Etfal Hastanesi Tip Bülteni, 49(4), 248.
12. Rapone, B., Ferrara, E., Corsalini, M., Converti, I., Grassi, F. R., Santacroce, L., Topi, S., Gnoni, A., Scacco, S., & Scarano, A. (2020). The effect of gaseous ozone therapy in conjunction with periodontal treatment on glycated hemoglobin level in subjects with type 2 diabetes mellitus: An unmasked randomized controlled trial. International journal of environmental research and public health, 17(15), 5467.
13. Rezaeianjam, M., Khabazian, A., Khabazian, T., Ghorbani, F., Abbasi, T., Asghari, S., Heidari, F., Shiri, A., & Naderi, M. (2025). Efficacy of ozone therapy in dentistry with approach of healing, pain management, and therapeutic outcomes: a systematic review of clinical trials. BMC Oral Health, 25(1), 433.
14. Sherov, U. (2022). Efficacy of metformin in combination ozone therapy in children and adolescents with metabolic syndrome. Central asian journal of theoretical and applied sciences, 03(10), 256-259.
15. Sroczynski, J., Grzeszczak, W., & Rudzki, H. (1994). Effects of intravenous ozone application on some parameters of lipid metabolism in experimental atherosclerosis in rabitts. Ann Acad Med Siles, 17(Suppl), 65-72.
16. Sundbom, M., Järvholm, K., Sjögren, L., Nowicka, P., & Lagerros, Y. T. (2024). Obesity treatment in adolescents and adults in the era of personalized medicine. Journal of internal medicine, 296(2), 139-155.
17. Tapia, A. S., & Sánchez, G. M. (2012). La ozonoterapia y su fundamentación científica. Revista Española de Ozonoterapia, 2(1), 163-198.
18. Tseveenmyadag, M. M., Khurelbaatar, S. M., & Tseveenmyadag, M. (2018). Some results of the outcome after ozone therapy diagnosed with diabetes. Биорадикалы и антиоксиданты, 5(3), 102-102.
19. Tylicki, L., Biedunkiewicz, B., Nieweglowski, T., Chamienia, A., Slizien, A. D., Luty, J., Lysiak‐Szydlowska, W., & Rutkowski, B. (2004). Ozonated autohemotherapy in patients on maintenance hemodialysis: influence on lipid profile and endothelium. Artificial organs, 28(2), 234-237.
20. Ugazio, E., Tullio, V., Binello, A., Tagliapietra, S., & Dosio, F. (2020). Ozonated oils as antimicrobial systems in topical applications. Their characterization, current applications, and advances in improved delivery techniques. Molecules, 25(2), 334.
21. Xie, T., Yan, W., Lou, J., & Chen, X. (2016). Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy. Genet Mol Res, 15(2), 1-11.