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İSKELET VE KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I.

Yıl 2005, Cilt: 16 Sayı: 2, 95 - 123, 01.04.2005

Öz

Kaynakça

  • Ahlborg, G., Hagenfeld, L. & Wahren, J. (1975). Substrate utilization by the inactive leg during one-leg or arm exercise. J. Appl. Physiol., 39(5), 718- 723.
  • Baker, S.K., McCullagh, K.J.A. & Bonen, A. (1998). Training intensity-dependent and tissue-spesific increases in lacta- te uptake and MCT-1 in heart and muscle. J. Appl. Physiol., 84(3), 987- 994.
  • Bangsbo, J., Johansen, L., Graham, T. & Sal- tin, B. (1993). Lactate and H+ efflu- xes from human skeletal muscles du- ring intense, dynamic exercise. J. Physiol., 462, 115-33.
  • Benton, C.R., Campbell, S.E., Tonouchi, M., Hatta, H. & Bonen, A. (2004). Mono- carboxylate transporters in subsarco- lemmal and intermyofibrillar mitoc- hondria. Biochem Biophys Res Com- mun., 323(1), 249-53.
  • Bonen, A. (2000). Lactate transporters (MCT proteins) in heart and skeletal musc- le. Med. Sci. Sports Exerc., 32 (4), 778-789.
  • Bonen, A. (2001). The expression of lactate transporters (MCT1 And MCT4) in he- art and muscle. Eur. J. Appl. Physiol., 86, 6-11.
  • Bonen, A., Baker, S.K. & Hatta, H. (1997). Lactate transport and lactate trans- porters in skeletal muscle. Can. J. Appl. Physiol., 22(6), 531-52.
  • Bonen, A. & Homonko, D. (1994). Effects of exercise and glycogen depletion on glyconeogenesis in muscle. J.Appl. Physiol., 76, 1753-1758.
  • Bonen, A. McDermott, J.C. & Tan, M.H. (1990). Glycogenesis and glycone- ogenesis in skeletal muscle: effects of pH and hormones. Am. J. Physiol., 258 (Endokrinol. Metab. 21), E693- E700.
  • Broer, S., Broer, A., Schneider, H-P., Stegen, C. & Halestrap, A.P. (1999). Characte- rization of the high-affinty monocar- boxilate transporter MCT2 in Xeno- pus Laevis oocytes. Biochem. J., 341, 529-535.
  • Broer, S., Rahman, B., Pellegri, G., Pellerin, L., Martin, J-L., Verleysdonk, S., Hamprecht, B. & Magistretti, P.J. (1997). Comparition of lactate trans- port in astroglial cells and Monocar- boxylate transporter 1 (MCT1) exprs- sing Xenopus laevis oocytes. Expres- sion of two different monocarboxyla- te transporters in astroglial cells and neurons. 272(48), 30096-30102.
  • Broer, S., Schneider, H.P., Broer, A., Rah- man, B., Hamprecht, B. & Deitmer, J.W. (1998). Characterization of the monocarboxylate transporter 1 exp- ressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J., 1;333( Pt 1), 167-74.
  • Brooks, G.A. (1991). Current concepts in lactate exchange. Med. Sci. Sports Exerc., 23(8), 895-906.
  • Brooks, G.A., Brown, M.A., Bunz, C.E., Sıcu- rello, J.P. & Dubouchaud, H. (1999). Cardiac and skeletal muscle mito- condria have a monocarboxylate transporter MCT1. J. Appl. Physiol., 87(5): 1713-1718.
  • Carpenter, L. & Halestrap, A.P. (1994). The kinetics, substrate and inhibitor spe- cificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF. Biochem J.,15;304 ( Pt 3), 751-60.
  • Carpenter, L., Poole, R.C. & Halestrap, A.P. (1996). Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and de- monstrates that glycosylation is not required for MCT1 function. Biochim. Biophys. Acta, 1279 (2), 157-163.
  • Dimmer, K.S., Friedrich, B., Lang, F., Deit- mer, J.W. & Broer, S. (2000). The low- affinity monocarboxylate transporter MCT4 is adapted to the export of lac- tate in highly glycolytic cells. Bioc- hem J., 15;350 (Pt 1), 219-27.
  • Dood, S.L., Powers, S.K., Callender, T. & Brooks, E. (1984). Blood lactate di- sappearance at variouse intensities of recovery exercise. J. Appl. Physi- ol., 57, 1462-1465.
  • Edlund, G.L. & Halestrap, A.P. (1988). The ki- netics of transport of lactate and pyruvate into rat hepatocytes. Evi- dence for the presence of a specific carrier similar to that in erythrocytes. Biochem J., 249(1), 117-26.
  • Eldridge, F.L. (1975). Relationshipe between turnover and blood concentration in exercise dogs. J. Appl. Physiol., 37, 316-320.
  • Fox, J.E.M., Meredith, D. & Halestrap, A.P. (2000). Characterisation of human monocarboxylate transporter 4 subs- tantiates its role in lactic acid efflux from skeletal muscle. J. Physiol., 529(2), 285-293.
  • Fishbein, W.N., Merezhinskaya, N. & Foell- mer, J.W. (2002). Relative distribution of three major lactate transporters in frozen human tissues and their locali- zation in unfixed skeletal muscle. Muscle Nerve, 26(1), 101-12.
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İSKELET VE KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I

Yıl 2005, Cilt: 16 Sayı: 2, 95 - 123, 01.04.2005

Öz

Laktik asit iskelet kasları için hem ana yakıt (oksidatif fibriller) hem de son üründür( glikolitik fibriller). Bu nedenle laktatın plazma membranında taşınımı, onun kasın içine girişi ve çıkışı için önemli bir düzenleyici mekanizmadır. Monokarboksil taşıyıcı proteinler (MCT) laktikasit, pürivik asit ve keton cisimleri gibi monokarboksilli asitleri taşıyan proton bağlantılı taşıyıcı proteinleridir. MCT’ler memelilerde aminoasit içeriğine göre belirlenmiş 14 üyeden oluşan büyük bir taşıyıcı protein ailesidir. Bu proteinlerin bazıları belirli bir dokuya özgünken,diğer bazıları birçok dokuda mevcuttur. İnsan ve sıçanların iskelet ve kalp kaslarında MCT1ve MCT4 olmak üzere iki izoform vardır. Bununla beraber iskelet kaslarında her iki izoformda (MCT1 ve MCT4) mevcutken, sıçanların kalp kasında sadece MCT1 bulunur. MCT1 ilekasın oksidatif fibril kompozisyonu arasında yüksek ilişki vardır. Kasın MCT1 içeriği ile dolaşımdan laktat alımı arasında da yüksek ilişki mevcuttur. MCT4 hızlı kasılan fibrillerle (hızlı glikolitik ve hızlı oksidatif glikolitik) sınırlıdır ve anaerobik metabolizma ile ilişkilidir. Böylece bubilgiler MCT1’in öncelikle dolaşımdan kasa, MCT4’ün ise kasdan dolaşıma laktik asitin taşınımından sorumlu olduğunu gösterir

Kaynakça

  • Ahlborg, G., Hagenfeld, L. & Wahren, J. (1975). Substrate utilization by the inactive leg during one-leg or arm exercise. J. Appl. Physiol., 39(5), 718- 723.
  • Baker, S.K., McCullagh, K.J.A. & Bonen, A. (1998). Training intensity-dependent and tissue-spesific increases in lacta- te uptake and MCT-1 in heart and muscle. J. Appl. Physiol., 84(3), 987- 994.
  • Bangsbo, J., Johansen, L., Graham, T. & Sal- tin, B. (1993). Lactate and H+ efflu- xes from human skeletal muscles du- ring intense, dynamic exercise. J. Physiol., 462, 115-33.
  • Benton, C.R., Campbell, S.E., Tonouchi, M., Hatta, H. & Bonen, A. (2004). Mono- carboxylate transporters in subsarco- lemmal and intermyofibrillar mitoc- hondria. Biochem Biophys Res Com- mun., 323(1), 249-53.
  • Bonen, A. (2000). Lactate transporters (MCT proteins) in heart and skeletal musc- le. Med. Sci. Sports Exerc., 32 (4), 778-789.
  • Bonen, A. (2001). The expression of lactate transporters (MCT1 And MCT4) in he- art and muscle. Eur. J. Appl. Physiol., 86, 6-11.
  • Bonen, A., Baker, S.K. & Hatta, H. (1997). Lactate transport and lactate trans- porters in skeletal muscle. Can. J. Appl. Physiol., 22(6), 531-52.
  • Bonen, A. & Homonko, D. (1994). Effects of exercise and glycogen depletion on glyconeogenesis in muscle. J.Appl. Physiol., 76, 1753-1758.
  • Bonen, A. McDermott, J.C. & Tan, M.H. (1990). Glycogenesis and glycone- ogenesis in skeletal muscle: effects of pH and hormones. Am. J. Physiol., 258 (Endokrinol. Metab. 21), E693- E700.
  • Broer, S., Broer, A., Schneider, H-P., Stegen, C. & Halestrap, A.P. (1999). Characte- rization of the high-affinty monocar- boxilate transporter MCT2 in Xeno- pus Laevis oocytes. Biochem. J., 341, 529-535.
  • Broer, S., Rahman, B., Pellegri, G., Pellerin, L., Martin, J-L., Verleysdonk, S., Hamprecht, B. & Magistretti, P.J. (1997). Comparition of lactate trans- port in astroglial cells and Monocar- boxylate transporter 1 (MCT1) exprs- sing Xenopus laevis oocytes. Expres- sion of two different monocarboxyla- te transporters in astroglial cells and neurons. 272(48), 30096-30102.
  • Broer, S., Schneider, H.P., Broer, A., Rah- man, B., Hamprecht, B. & Deitmer, J.W. (1998). Characterization of the monocarboxylate transporter 1 exp- ressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J., 1;333( Pt 1), 167-74.
  • Brooks, G.A. (1991). Current concepts in lactate exchange. Med. Sci. Sports Exerc., 23(8), 895-906.
  • Brooks, G.A., Brown, M.A., Bunz, C.E., Sıcu- rello, J.P. & Dubouchaud, H. (1999). Cardiac and skeletal muscle mito- condria have a monocarboxylate transporter MCT1. J. Appl. Physiol., 87(5): 1713-1718.
  • Carpenter, L. & Halestrap, A.P. (1994). The kinetics, substrate and inhibitor spe- cificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF. Biochem J.,15;304 ( Pt 3), 751-60.
  • Carpenter, L., Poole, R.C. & Halestrap, A.P. (1996). Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and de- monstrates that glycosylation is not required for MCT1 function. Biochim. Biophys. Acta, 1279 (2), 157-163.
  • Dimmer, K.S., Friedrich, B., Lang, F., Deit- mer, J.W. & Broer, S. (2000). The low- affinity monocarboxylate transporter MCT4 is adapted to the export of lac- tate in highly glycolytic cells. Bioc- hem J., 15;350 (Pt 1), 219-27.
  • Dood, S.L., Powers, S.K., Callender, T. & Brooks, E. (1984). Blood lactate di- sappearance at variouse intensities of recovery exercise. J. Appl. Physi- ol., 57, 1462-1465.
  • Edlund, G.L. & Halestrap, A.P. (1988). The ki- netics of transport of lactate and pyruvate into rat hepatocytes. Evi- dence for the presence of a specific carrier similar to that in erythrocytes. Biochem J., 249(1), 117-26.
  • Eldridge, F.L. (1975). Relationshipe between turnover and blood concentration in exercise dogs. J. Appl. Physiol., 37, 316-320.
  • Fox, J.E.M., Meredith, D. & Halestrap, A.P. (2000). Characterisation of human monocarboxylate transporter 4 subs- tantiates its role in lactic acid efflux from skeletal muscle. J. Physiol., 529(2), 285-293.
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  • McCullagh, K.J.A., Poole, R.C., Halestrap, A.P., O’brien, M. & Bonen, A. (1996). Role of the lactate transporter (MCT1) in skeletal muscle. Am. J. Physiol. 271 (Endocrinol. Metab. 34), E143- E150.
  • McDermott, J.C. & Bonen, A. (1992). Glyco- neogenic and oxidative lactate utili- zation in skeletal muscle. Can. J. Physiol. Pharmacol.,70(1), 142-9.
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  • Pagliassotti, M.J. & Donovan, C. (1990). Ro- le of cell type in net lactate removal by skeletal muscle. Am, J. Physiol., 258, E635-E642.
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  • Philp, N.J., Yoon, H. & Grollman, E.F. (1998). Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Am. J. Physiol., 274 (6 Pt 2), R1824-R1828.
  • Philp, N.J., Yoon, H. & Lombardi, L. (2001). Mouse MCT3 gene is expressed pre- ferentially in retinal pigment and cho- roid plexus epithelia. Am. J. Physiol., 280, C1319-C1326.
  • Pilegaard, H., Terzis, G., Halestrap, A.P. & Jeul C. (1999). Distribution of the lac- tate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab., 276, E843-E848.
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  • Poole, R.C. & Halestrap, A.P. (1992). Identifi- cation and partial purification of the erythrocyte L-lactate transporter. Bi- ochem. J., 283(Pt 3), 855-62.
  • Poole, R.C. & Halestrap, A.P. (1993). Trans- port of lactate and other monocar- boxylates across mammalian plasma membranes. Am. J. Physiol. , 264 (4 Pt 1), C761-C782.
  • Poole, R.C. & Halestrap, A.P. (1994). N-ter- minal protein sequence analysis of the rabbit erythrocyte lactate trans- porter suggests identity with the clo- ned monocarboxylate transport pro- tein MCT1. Biochem. J., 303 (Pt 3), 755-9.
  • Poortsmans, J.R., Bossche, J.V.D. & Lec- lercq, R. (1978). Lactate uptake by inactive forearm during progressive leg exercise. J. Appl. Physiol.: Respi- rat. Environs. Exercise Physiol., 45(6), 835-839.
  • Price, N.T., Jackson, V.N. & Halestrap, A.P. (1998). Cloning and sequencing of fo- ur new mammalian monocarboxylate transporter (MCT) homologues con- firms the existence of a transporter family with an ancient past. Bioc- hem. J., 329 (Pt 2), 321-328.
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  • Takanaga, H., Tamai, I., Inaba, S., Sai, Y., Hi- gashida, H., Yamamoto, H. & Tsuji, A. (1995). cDNA cloning and functional characterization of rat intestinal mo- nocarboxylate transporter. Biochem. Biophys. Res. Commun., 217(1), 370- 377.
  • Tamai, I., Takanaga, H., Maeda, H., Sai, Y., Ogihara, T., Higashida, H. & Tsuji, A. (1995). Participation of a proton-cot- ransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun., 214(2), 482-9.
  • Wilson, M.C., Jackson, V.N., Heddle, C., Pri- ce, N.T., Pilegaard, H., Juel, C., Bo- nen, A., Montgomery,I., Hutter, O.F. & Halestrap, A.P. (1998). Lactic acid eff- lux from white skeletal muscle is ca- talyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem., 273(26), 15920-15926.
  • Wang, X., Levi, A.J. & Halestrap, A.P. (1994). Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi. Am. J. Physiol., 267(5 Pt 2), H1759-69.
  • Yoon, H., Donoso, L.A. & Philp, N.J. (1999). Cloning of the human monocarboxy- late transporter MCT3 gene: localiza- tion to chromosome 22q12.3-q13.2. Genomics, 60(3), 366-370.
  • Yoon, H., Fanelli, A., Grollman,E.F. & Philp, N.J. (1997). Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium. Bioc- hem. Biophys. Res. Commun., 234 (1), 90-94.
Toplam 85 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Tahir Hazır Bu kişi benim

Caner Açıkada Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2005
Gönderilme Tarihi 31 Ocak 2015
Yayımlandığı Sayı Yıl 2005 Cilt: 16 Sayı: 2

Kaynak Göster

APA Hazır, T., & Açıkada, C. (2005). İSKELET VE KALP KASLARINDA LAKTİK ASİTİN TAŞINIMI: MONOKARBOKSİL TAŞIYICI PROTEİNLER BÖLÜM I. Spor Bilimleri Dergisi, 16(2), 95-123.

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