Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi

Hacer Alataş; Mendane Saka

Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi

Öz

Gastrointestinal sistemdeki bakteri türü ve konsantrasyonu fetal hayattan yaşlılığa kadar birçok etkenin etkisiyle değişime uğramaktadır. Kronik böbrek yetmezliği (KBY) görülen bireylerde artan üremi, metabolik asidoz, verilen diyet kısıtlamaları, uygulanan tıbbi tedavilerin etkisi, kolonik geçiş zamanının uzaması gibi birçok neden intestinal mikrobiyota florasında ve fonksiyonunda değişmelere neden olmaktadır. Bu değişiklikler kolonun mikrobiyal protein fermantasyonunu değiştirmekte ve üremik toksinlerin oluşumunu arttırmaktadır. Bu toksik maddeler intestinal lümendeki sıkı bağlantı (tight junction) proteinlerine zarar vermekte ve bağırsağın koruyucu epitelyal bariyerini bozmaktadır. Sonuçta bağırsak kaynaklı üremik toksinler sistemik dolaşıma geçmekte KBY progresyonuna, kardiyovasküler hastalıklara (KVH), insülin direncine, inflamasyona ve protein-enerji malnütrisyonuna katkıda bulunmaktadır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Hacer Alataş ^*
0000-0002-6441-0362
Türkiye

Mendane Saka
0000-0002-5516-426X
Türkiye

Yayımlanma Tarihi

24 Aralık 2021

Gönderilme Tarihi

27 Ağustos 2021

Kabul Tarihi

27 Ekim 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 5 Sayı: 1

IZ

https://izlik.org/JA72UC62AH

Kaynak Göster

RIS / Bibtex

APA

Alataş, H., & Saka, M. (2021). Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. Sağlık Bilimleri ve Yaşam Dergisi, 5(1), 37-46. https://izlik.org/JA72UC62AH

AMA

1.Alataş H, Saka M. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD. 2021;5(1):37-46. https://izlik.org/JA72UC62AH

Chicago

Alataş, Hacer, ve Mendane Saka. 2021. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi”. Sağlık Bilimleri ve Yaşam Dergisi 5 (1): 37-46. https://izlik.org/JA72UC62AH.

EndNote

Alataş H, Saka M (01 Aralık 2021) Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. Sağlık Bilimleri ve Yaşam Dergisi 5 1 37–46.

IEEE

[1]H. Alataş ve M. Saka, “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi”, SBYD, c. 5, sy 1, ss. 37–46, Ara. 2021, [çevrimiçi]. Erişim adresi: https://izlik.org/JA72UC62AH

ISNAD

Alataş, Hacer - Saka, Mendane. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi”. Sağlık Bilimleri ve Yaşam Dergisi 5/1 (01 Aralık 2021): 37-46. https://izlik.org/JA72UC62AH.

JAMA

1.Alataş H, Saka M. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD. 2021;5:37–46.

MLA

Alataş, Hacer, ve Mendane Saka. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi”. Sağlık Bilimleri ve Yaşam Dergisi, c. 5, sy 1, Aralık 2021, ss. 37-46, https://izlik.org/JA72UC62AH.

Vancouver

1.Hacer Alataş, Mendane Saka. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD [Internet]. 01 Aralık 2021;5(1):37-46. Erişim adresi: https://izlik.org/JA72UC62AH