3,4-Dietilpirolün Sentezi ve Karakterizasyonu

Yıl 2006, Cilt: 10 Sayı: 1, 21 - 24, 10.04.2009

B. Dede A. Gülce

Öz

Pirol ve türevleri organik ve biyokimyada önemli heterosiklik bileşiklerdir ve birçok doğal üründe bulunmaktadırlar. Bu çalışmada, porfirin vb. gibi doğal ürünlerin sentezinde kullanılabilecek bir bileşik olan 3,4-dietilpirolün sentezi gerçekleştirilmiştir. Bu amaç için ilk önce bir α-halojenleme reaksiyonu ile bütanalden 2-bromobütanal elde edilmiş ve yine bütanal, morfolin ile etkileştirilerek 1-morfolino-1-büten enamini sentezlenmiştir. 2-Bromobutanal ve 1-morfolino-1-büten uygun şartlarda etkileştirilerek 2,3-dietilsüksinaldehit elde edilmiştir. 2,3-Dietilsüksinaldehitin amonyum karbonat ile reaksiyonu sonucu 3,4-dietilpirol sentezlenmiştir.

Anahtar Kelimeler

Pirol, enamin, 3, 4-disübstitüe pirol

Kaynakça

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