Nanotel Yapılı Kalem Grafit Elektrotlar Kullanılarak Prometazinin Voltametrik Tayini

Yıl 2020, Cilt: 24 Sayı: 3, 659 - 668, 25.12.2020

Tuğba Sardohan Köseoğlu , Aybüke Durgut

https://doi.org/10.19113/sdufenbed.787612

Öz

Çalışmada, prometazin tayini için kalem grafit elektrot (KGE) temelli polimerik nanotel yapılı elektrotlar (KGE-AY-NT1 ve KGE-AY-NT2) hazırlanmıştır. Döngü sayısı, tarama hızı ve ortam pH değeri gibi parametreler optimize edilmiştir. Yapılan deneyler sonucunda, optimum döngü sayısı 4, tarama hızı 100 mV/s ve ortamın pH değeri 4 olarak belirlenmiştir. Elektrotlar dönüşümlü voltametri (CV) yöntemi ile hazırlanmıştır. Elektrotların prometazin tayini üzerindeki performansı ise diferansiyel puls voltametrisi (DPV) yöntemi ile araştırılmıştır. Doğrusal çalışma aralığına 0.05-0.3 mM prometazin derişim aralığında (KGE-AY-NT1; R2=0.9995 ve KGE-AY-NT2; R2=0.9996) ulaşılmıştır. KGE-AY-NT1 ve KGE-AY-NT2 elektrotlar için gözlenebilme sınırları (LOD) sırasıyla 0.015 mM ve 0.012 mM olarak bulunmuştur (S/N=3). Girişim etkisi deney sonuçları, KGE-AY-NT1 ve KGE-AY-NT2 elektrotlarının prometazine karşı seçicilik ve hassasiyetinin, girişim yapan türlerin varlığından önemli ölçüde etkilenmediğini göstermiştir. Geliştirilen elektrotlar, standart ekleme yöntemi ile idrar numunesine katkılandırılmış prometazinin tayininde uygulanmış ve yöntemin geri kazanım değerlerinin %100’e yakın olduğu belirlenmiştir.

Anahtar Kelimeler

Aşırı Yükseltgeme, Kalem grafit elektrot, Nanotel yapılı elektrot, Prometazin, Voltametri

Voltammetric Determination of Promethazine Using Pencil Graphite Electrodes with Nanowire Structured

Öz

Anahtar Kelimeler

Overoxidation, Pencil graphite electrode, Nanowire structured electrode, Promethazine, Voltammetry

Kaynakça

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