An Overview of Drug-loaded Contact Lenses

Öz

Objective: Within the scope of this review, contact lens types designed for the treatment of ocular diseases, different drug loading methods, and in vitro and in vivo studies performed after drug loading are examined. Result and Discussion: Topical ocular dosage forms have numerous problems, including low bioavailability, poor patient compliance, and potential side effects. Innovative ocular drug delivery systems are being studied to overcome the limitations associated with traditional formulations. One of these systems is drug-loaded contact lenses, which prolong the duration of drug retention in the eye and reduce the occurrence of side effects. Drug-loaded contact lenses have been effectively manufactured using a variety of techniques, including dipping, molecular imprinting, supercritical fluid nanosystems, and vitamin E modification technologies. These techniques have also proved successful in extending the drug's release period. The preparation techniques, in vitro and in vivo research, and future possibilities for drug-loaded contact lenses are all evaluated in this review of the most recent developments in the treatment of ocular illnesses.

Anahtar Kelimeler

• Eye
• Ocular System
• Contact Lens
• Nanosystem
• Vitamin E
• Molecular Imprinting

İlaç Yüklü Kontakt Lenslere Genel Bakış

Öz

Amaç: Bu derleme kapsamında oküler hastalıkaların tedavisi için tasarlanan kontakt lens tipleri, bu kontakt lenslere ilaç yükleme yöntemleri ve ilaç yüklemesi sonrası yapılan in vitro ve in vivo çalışmalar incelenmiştir. Sonuç ve Tartışma: Topikal oküler ilaçların; düşük biyoyararlanım, zayıf hasta uyuncu ve yüksek yan etki oluşma ihtimali gibi pek çok sorunu bulunmaktadır. Klasik formülasyonlarla ilişkili sınırlamaların üstesinden gelmek için yeni oküler ilaç taşıyıcı sistemler geliştirmek üzere çalışmalar yapılmaktadır. Bu sistemlerden birisi de ilaçların gözde kalış süresini uzatan, yan etki oluşumunu azaltan bir sistem olan ilaç yüklü kontakt lenslerdir. İlaç yüklü kontakt lenslere; daldırma, moleküler baskılama, nanosistemler, E vitamini değişimi ve süperkritik sıvı teknolojisi gibi çeşitli yöntemler başarıyla uygulanmış ve ilaçların salım süresi uzatılmıştır. Bu yayında, ilaç yüklü kontakt lenslerin hazırlanma yöntemleri, yapılan in vitro ve in vivo çalışamaları ve geleceğe yönelik beklentiler de dahil olmak üzere oküler hastalıkların tedavisindeki son gelişmeler değerlendirilmektedir.

Anahtar Kelimeler

• Göz
• Oküler Sistem
• Kontakt Lens
• Nanosistem
• Vitamin E
• Moleküler Baskılama

Kaynakça

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