Role of microRNAs (miRNAs) in tumor angiogenesis

Öz

Angiogenesis is a controlled process that occurs in; developmental events of embryonic and post embryonic periods, wound and tissue healing and also events of female reproductive system. Nevertheless angiogenesis can be observed as an uncontrolled and so a pathological process in cancers, some inflamtory diseases and eye diseases. miRNAs are non protein coding small RNA molecules. The researches shoved that miRNAs play some important roles in the cell. Also the expression changes of some miRNAs is associated with angiogenesis and cancer development. For these reasons in recent years, the interest on miRNAs has increased in the studies aiming to understand molecular basis of cancer and treatment of it. Key words: Cancer, angiogenesis, miRNA

Anahtar Kelimeler

• Cancer, angiogenesis,miRNA

Tümör anjiyogenezinde mikroRNA (miRNA)'ların rolü

Öz

Anjiyogenez; embriyonik-post-embriyonik dönemde gelişme, yara ve doku hasarlarının iyileştirilmesi ve dişi üreme sistemindeki olaylarda, kontrol altında gerçekleşmekte olan bir süreçtir. Kanserler, bazı inflamatuvar durumlar ve göz hastalıklarında kontrolsüz gerçekleşip patolojik bir durum olarak gözlenmektedir. miRNA'lar protein kodlamayan küçük RNA molekülleridir. Yapılan araştırmalar, miRNA'ların hücrede önemli roller üstlendiğini göstermiştir. Ayrıca bazı miRNA'ların ekspresyonlarının değişimi, kanser gelişimiyle ve anjiyogenezle ilişkilendirilmiştir. Bu nedenle son yıllarda ilgi kanserin moleküler temelinin anlaşılması ve tedavisine yönelik çalışmalarda miRNA'lara olan ilgi artmıştır. Anahtar kelimeler: Kanser, anjiyogenez, miRNA

Anahtar Kelimeler

• Kanser, anjiyogenez, miRNA

Kaynakça

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