N-acetyl cysteine and acute kidney injury after cardiac surgery

Öz

Acute kidney injury (AKI) is a very common and important complication of cardiac surgery. It is associated with severe complications including mortality. Cardiac surgery may induce oxidative stress and inflammation and both of these processes may be associated with AKI. N-acetyl cysteine (NAC) is a mucolytic agent and it has antioxidant and anti-inflammatory properties. Although positive results have been obtained in animal studies, however; no significant beneficial effects of NAC on AKI have been found in randomized studies and meta-analyses. Currently available data do not support to recommend NAC for the prevention of AKI after cardiac surgery.

Anahtar Kelimeler

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N-asetil sistein ve Kardiyak cerrahi sonrası akut böbrek hasarı

Öz

Akut böbrek hasarı (ABH), kalp cerrahisinin önemli ve sık bir komplikasyonudur. Bu durum ciddi mortaliteyi de içeren ciddi komplikasyonlarla ilişkilidir. Kardiyak cerrahi, oksidatif stresi veya inflamasyonu veya her ikisini birden indükleyerek ABH'na sebep olabilmektedir. N-asetil sistein (NAS) antioksidan ve antiinflamatuvar özellikleri olan bir mukolitik ajandır. Hayvan çalışmalarında pozitif sonuçları gözlenmekle beraber randomize kontrollü çalışmalarda ve meta analizlerde NAS'nin, ABH'na anlamlı faydalı etkileri saptanmamıştır. Halihazırdaki veriler, kalp cerrahisi sonrası ABH'ndan korunmada NAS kullanımını desteklememektedir.

Anahtar Kelimeler

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Kaynakça

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