Plateletcrit Could Be A Marker of Inflammation in Cesarean Section

Yıl 2019, , 66 - 69, 21.03.2019

İbrahim Karagöz , Ayhan Ekici

https://doi.org/10.22312/sdusbed.523163

Öz

Amaç: Hemogram kökenli yeni inflamatuar belirteçlerin;
özellikle nötrofil / lenfosit oranı (NLR), ortalama trombosit hacmi (MPV),
kırmızı hücre dağılım genişliği (RDW), MPV - trombosit oranı (MPR), RDW /
trombosit oranı (RPR) ve trombosit oranı (MPT) preoperatif ve postoperatif
değerlerini genel veya spinal anestezi ile sezaryen yapılan gebelerde
karşılaştırmayı amaçladık.

Materyal-Metod: Çalışmamızda genel ve bölgesel anestezi için herhangi
bir kontrendikasyonu olmayan, tek bir fetüs gebeliği olan, 18-40 yaşları
arasındaki seçmeli sezaryen bölümü olan hastalar çalışmaya alındı. Denekler
rastgele iki gruba ayrıldı. Grup I (n = 30) hastalara genel anestezi, Grup II
(n = 30) hastalara spinal anestezi uygulandı. Preoperatif ve postoperatif
hemogram parametreleri karşılaştırıldı.

Bulgular: Spinal ve genel anestezi gruplarının postoperatif PCT
değerleri sırasıyla% 0.16 (0.05) ve% 0.19 (0.07) idi. Postoperatif PCT'deki
fark istatistiksel olarak anlamlıydı (p = 0.03).

Sonuç: Sezaryen ameliyatı sonrası PCT'nin inflamasyon
belirteci olarak kullanılabileceğini düşünüyoruz. Kontrendike değilse, sezaryen
doğumundaki gebe kadınlar için spinal anestezi tercih edilmelidir.

Anahtar Kelimeler

plateletcrit, İnflamasyon, sezaryen cerrahisi

Kaynakça

• Referans1. Acar D, Karakaş Erkılıç E, Gümüş T, Şahin D, Sepici Dinçel A, Kanbak O. The Effects of Different Anaesthetic Techniques on Surgical Stress Response During Inguinal Hernia Operations. Turkish Journal of Anesthesiology and Reanimation. 2015;43(2):91-9.
• Referans2. Akkaya A, Yildiz I, Tekelioglu UY, Demirhan A, Bayir H, Ozlu T, et al. Dexamethasone added to levobupivacaine in ultrasound-guided tranversus abdominis plain block increased the duration of postoperative analgesia after caesarean section: a randomized, double blind, controlled trial. European review for medical and pharmacological sciences. 2014;18(5):717-22.
• Referans3. Dogan N, Kursad H, Alici HA, Cesur M. The Effects of General and Epidural Anaesthesia on the number of Leukocytes and the distribution of Leukocyte subtypes. Medical Journal of Ataturk University. 2003;35:37-41.
• Referans4. Aydın M, Şenol DK, Erdoğan S. Determination of Preoperative Anxiety Levels on Women Scheduled for Caesarean Delivery. ACU Sağlık Bil Derg. 2014;2014(1):54-8.
• Referans5. Aksoy M, Aksoy AN, Dostbil A, Gürsaç Çelik M, Ahıskalıoğlu A. Anaesthesia Techniques for Caesarean Operations: Retrospective Analysis of Last Decade. Turk J Anaesth Reanim 2014;42:128-32.
• Referans6. Salo M. Effects of anaesthesia and surgery on the immune response. Acta anaesthesiologica Scandinavica. 1992;36(3):201-20.
• Referans7. Kelbel I, Weiss M. Anaesthetics and immune function. Current opinion in anaesthesiology. 2001;14(6):685-91.
• Referans8. Atak BM, Duman TT, Aktas G, Kocak MZ, Savli H. Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy. National Journal of Health Sciences 2018;3:95-8.
• Referans9. Aktas G, Kocak MZ, Duman TT, Erkus E, Atak BM, Sit M, et al. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Medical Journal. 2018;7(3):650-3.
• Referans10. Aktas G, Sit M, Karagoz I, Erkus E, Ozer B, Kocak MZ, et al. Could Red Cell Distribution Width be a Marker of Thyroid Cancer? Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2017;27(9):556-8.
• Referans11. Kocak MZ, Aktas G, Erkus E, Duman TT, Atak BM, Savli H. Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2018;28(11):844-7.
• Referans12. Duman TT, Aktas G, Atak B, Kocak MZ. Is Mean Platelet Volume to Platelet ratio a promising indicator of diabetic regulation in type 2 diabetes mellitus? Journal of Medical Research. 2018;4(3):137-9.
• Referans13. Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E, et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Revista da Associacao Medica Brasileira (1992). 2017;63(12):1065-8.
• Referans14. Kosekli MA, Erkus E, Kocak MZ. Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis. Experimental Biomedical Research. 2018;1(2):55-9.
• Referans15. Atak BM, Erkus E, Duman TT, Kocak MZ, Kosekli MA. Mean Platelet volume to platelet and red cell distribution width to platelet ratios in Irritable Bowel Syndrome. Experimental Biomedical Research. 2018;1(2):60-4.
• Referans16. Tang J, Gao X, Zhi M, Zhou HM, Zhang M, Chen HW, et al. Plateletcrit: a sensitive biomarker for evaluating disease activity in Crohn's disease with low hs-CRP. Journal of digestive diseases. 2015;16(3):118-24.
• Referans17. Ergelen M, Uyarel H. Plateletcrit: a novel prognostic marker for acute coronary syndrome. International journal of cardiology. 2014;177(1):161.
• Referans18. Sahin F, Yazar E, Yildiz P. Prominent features of platelet count, plateletcrit, mean platelet volume and platelet distribution width in pulmonary tuberculosis. Multidisciplinary respiratory medicine. 2012;7(1):38.
• Referans19. Akpinar I, Sayin MR, Gursoy YC, Aktop Z, Karabag T, Kucuk E, et al. Plateletcrit and red cell distribution width are independent predictors of the slow coronary flow phenomenon. Journal of cardiology. 2014;63(2):112-8.
• Referans20. Yilmaz Z, Eralp O, Ilcol YO. Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia. Veterinary clinical pathology. 2008;37(2):159-63.
• Referans21. Tuzun A, Keskin O, Yakut M, Kalkan C, Soykan I. The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors. Platelets. 2014;25(5):363-6.
• Referans22. Gul M, Uyarel H, Akgul O, Akkaya E, Surgit O, Cakmak HA, et al. Long-term prognostic significance of admission plateletcrit values in patients with non-ST elevation myocardial infarction. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2016;27(6):696-701.
• Referans23. Aynioglu O, Isik H, Sahbaz A, Harma MI, Isik M, Kokturk F. Can Plateletcrit be a Marker for Recurrent Pregnancy Loss? Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2016;22(5):447-52.
• Referans24. Isik H, Aynioglu O, Sahbaz A, Arikan I, Karcaaltincaba D, Sahin H, et al. Can plateletcrit, an underestimated platelet parameter, be related with preterm labour? Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2015;35(7):676-80.
• Referans25. Yucel B, Ustun B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy hypertension. 2017;7:29-32.
• Referans26. Torres LM, Martinez Ruiz A. Inflammation and anesthesia, is there anything new? Revista espanola de anestesiologia y reanimacion. 2017;64(7):365-8.
• Referans27. Baki ED, Sivaci RG, Kokulu S, Ela Y, Aldemir M. Effects of anesthetic choice on inflammatory response in cardiac surgery. Inflammation and Cell Signaling. 2014;1:e75.
• Referans28. Galley HF, Dubbels AM, Webster NR. The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes. Anesthesia & Analgesia. 1998;86(6):1289-93.
• Referans29. Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. BMJ open. 2018;8(12):e020757.
• Referans30. Ata N, Erdur O, Görgülü M, Yilmaz E. Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections. The Journal of Laryngology & Otology. 2016;130(12):1153-7.
• Referans31. Brix-Christensen V, Tonnesen E, Sorensen IJ, Bilfinger TV, Sanchez RG, Stefano GB. Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery. Acta anaesthesiologica Scandinavica. 1998;42(1):63-70.
• Referans32. Winterhalter M, Brandl K, Rahe-Meyer N, Osthaus A, Hecker H, Hagl C, et al. Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl. European journal of anaesthesiology. 2008;25(4):326-35.