Asemptomatik Tam Gömük Alt Yirmi Yaş Dişlerinin Foliküllerinde Ki-67 ve p53 Ekspresyonunun Değerlendirilmesi

Yıl 2017, Cilt: 8 Sayı: 3, 1 - 7, 20.12.2017

Ender Burhanoğlu , Müge Çına Aksoy , Pınar Aslan Koşar

https://doi.org/10.22312/sdusbed.295857

Öz

AMAÇ:
Gömük diş çekimi, özellikle en sık gömük kalan dişler olan alt yirmi yaş
dişlerinin çekimi, en çok gerçekleştirilen oral cerrahi işlemdir. Asemptomatik
tam gömük alt yirmi yaş dişlerinin çekimi konusunda net bir görüş birliğine
varılamamıştır. Ki-67, farklı hücre populasyonlarının büyüme hızını yani
proliferasyon indeksini belirlemede kullanılmaktadır. p53 ise tümör baskılayıcı
bir proteindir. Sağlıklı dokuların tersine, tümör hücrelerinde p53 proteininin
ekspresyonu artmaktadır. Bu çalışmanın amacı, sigara kullanan ve kullanmayan
bireylerin, asemptomatik tam gömük alt yirmi yaş dişlerinin perikoronal
foliküllerinde p53 ve Ki-67 proteinlerinin ekspresyonlarının
karşılaştırılmasıdır.

MATERYAL
METOD: Çalışmaya 50 sigara kullanan, 50 sigara kullanmayan 100 hastadan,
asemptomatik tam gömük alt yirmi yaş dişlerinin perikoronal folikülleri dahil
edilmiştir. Dokularda, p53 ve Ki-67 antikorları ile immunohistokimyasal boyama
yapılarak immünhistokimyasal olarak, hücre çekirdeği boyanan hücre sayısı ve
boyanma yoğunlukları skorlanarak değerlendirilmiştir.

BULGULAR:
Çalışmamızda, sigara kullanan ve kullanmayan hastaların perikoronal
foliküllerinde, Ki-67 ve p53 proteinlerinin boyanması “negatif” olarak bulundu.

SONUÇ:
Çalışmamızın sonuçlarına göre, her ne kadar sigaranın genel sağlık açısından
bir risk faktörü oluşturduğu biliniyor olsa da, asemptomatik tam gömük dişlerin
patolojik dönüşüm riskini arttırdığına dair net bir kanıt bulunamamıştır. Gömük
alt yirmi yaş dişlerinin çekimine, detaylı klinik ve radyografik muayene ile
birlikte hastanın sosyokültürel düzeyi göz önünde bulundurularak, karar
verilmesi uygun bir seçenek olabilir.

Anahtar Kelimeler

Dental folikül, immunohistokimya, Ki-67, p53

Kaynakça

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