BİR EĞİTİM VE ARAŞTIRMA HASTANESİNDE COVİD-19 ENFEKSİYONU NEDENİ İLE İMMÜN PLAZMA UYGULANAN HASTALARIN DEĞERLENDİRİLMESİ

Öz

Amaç COVID-19 enfeksiyonu tedavisi için immün plazma uygulanan hastaların demografik ve klinik verilerinin ve immün plazma transfüzyonu ile ilişkili reaksiyonların değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Etik kurul onayı alınılan çalışma, retrospektif ve tanımlayıcı bir araştırmadır. 2020 yılında COVİD-19 enfeksiyonu nedeniyle immün plazma uygulanan 130 hasta çalışmaya dahil edildi. Hastaların dosyaları ve transfüzyon merkezi sisteminde kayıtlı olan bilgileri değerlendirilerek araştırmacılar tarafından SPSS paket programı kullanılarak analiz edildi. Bulgular İmmün plazma klinik uygulama kriterlerini sağlayan 130 hastaya 154 kez immün plazma transfüzyon uygulaması yapıldı. Hastaların bir ya da birden fazla kötü prognostik ölçüte sahip, orta ve ağır pnömoni hastaları olduğu, ortalama 17,9 gün hastanede yatarak tedavi gördüğü, %35,4’ünde sürecin ölümle sonuçlandığı belirlendi. İmmun plazma transfüzyon reaksiyonu sıklığı %1,95 olarak saptandı. Anti - A antikoruna sahip hastalarda %23,1’inde sürecin ölümle sonuçlandığı belirlendi. Sonuç İmmün plazma uygulanan bir veya daha fazla kötü prognostik kritere sahip orta ve şiddetli pnömonili hastalar hakkında veri sağlanmasının literatüre katkıda bulunabileceği düşünülmektedir.

Anahtar Kelimeler

• İmmun plazma
• Prognoz
• Transfüzyon reaksiyonu
• ABO gruplar

EVALUATION OF PATIENTS WHO RECEIVED IMMUNE PLASMA DUE TO COVID-19 INFECTION IN AN EDUCATIONAL AND RESEARCH HOSPITAL

Öz

Objective It is aimed to evaluate the demographic and clinical data of patients receiving immune plasma for the treatment of COVID-19 infection and reactions associated with uygulamaimmune plasma transfusion. Materials and Methods The study, which received the approval of the ethics committee, is a retrospective and descriptive study. In 2020, 130 patients who were administered immune plasma due to COVID-19 infection were included in the study. The patients' files and information stored in the transfusion center system were evaluated and analyzed by the researchers using the SPSS package program. Results Immune plasma transfusion was performed 154 times in 130 patients who met the criteria for clinical application of immune plasma. It was determined that the patients had moderate and severe pneumonia with one or more poor prognostic criteria, were hospitalized for an average of 17.9 days, and the process resulted in death in 35.4% of them. The frequency of immune plasma transfusion reaction was found to be 1.95%. It was determined that the process resulted in death in 23.1% of patients with anti - A antibody. Conclusion It is thought that the provision of data on patients with moderate and severe pneumonia with one or more poor prognostic criteria undergoing immune plasma may contribute to the literature.

Anahtar Kelimeler

• Immune plasma
• Prognosis
• Transfusion reaction
• ABO groups

Kaynakça

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