MOLECULAR PATHOGENESIS OF PROSTATE CANCER

Öz

Prostate cancer is the second most common cause of death in men worldwide, after lung carcinoma. Although early treatment and preventive medicine practices came to the fore in the era of PSA followup, and subsequent needle biopsies made it easier to detect the tumor development of the patients, but we did not have much chance in terms of determining the behavior of the tumor especially before, during and after the treatment, except for risk scoring schemes. Today, the molecular signature and molecular biology of the disease, which we can use to determine individual treatment models and to predict the prognosis of the disease, are important. For all these reasons, medical professional's knowledge of the molecular pathogenesis and biological attitude of prostate cancer will help to understand the disease and its course.

Anahtar Kelimeler

• Advanced disease
• Biology of prostate
• ETS positive and negative PCa
• Molecular pathogenesis
• Prostate cancer
• ETS pozitif ve negatif PCa
• İleri evre hastalık
• Moleküler patogenez
• Prostat biyolojisi
• Prostat kanseri

PROSTAT KANSERİ MOLEKÜLER PATOGENEZİ

Öz

Prostat kanseri dünya genelinde erkeklerde akciğer karsinomundan sonra 2. en sık ölüme yol açan kanserlerdir. Her ne kadar erken tedavi ve koruyucu hekimlik uygulamalarının PSA takibi şeklinde ön plana çıkmasıyla, devamında iğne biyopsilerle hastaların tümör gelişiminin saptanması kolaylaşmış olsa da tümörün özellikle tedavi öncesinde, sırasında ve sonrasındaki davranışlarının belirlenmesi anlamında elimizde risk skorlama şemaları dışında pek bir şansımız yoktu. Günümüzde kişiye özgü tedavi modellerini belirlemede ve hastalığın ileri evre olmadan prognozunu tahmin etmede kullanabileceğimiz moleküler imzası ve moleküler biyolojisi önem arz etmektedir. Tüm bu nedenlerle prostat kanserinin moleküler patogenezi ve biyolojik davranışının medikal profesyoneller tarafından bilinmesi hastalığı ve seyrini anlamada bize yardımcı olacaktır.

Anahtar Kelimeler

• ETS pozitif ve negatif PCa
• İleri evre hastalık
• Moleküler patogenez
• Prostat biyolojisi
• Prostat kanseri

Kaynakça

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