PLAZMA APELİN DÜZEYİ VE PRE-EKLAMPSİ VAKALARI ARASINDAKİ BAĞLANTININ ARAŞTIRILMASI

Year 2023, , 211 - 216, 22.06.2023

Rahim Kocabaş , Melike Geyik Bayman , Fatih Zeytin , Ercan Karabulut , Mehmet Aköz

https://doi.org/10.17343/sdutfd.1241625

Abstract

Amaç
Gebelikte gelişen ve multi-sistemik bir hastalık olan
pre-eklampsi, yılda en az 42.000 anne ölümüne sebep
olan bir patolojidir. Pre-eklampsi patofizyolojisine
ilişkin teoriler, temel olarak yüzeysel plasentasyon ile
ilişkili olduğu düşünülen maternal-fetal immün malperfüzyona
dayanmakta ve pre-eklampsinin nedeni
ise henüz tam olarak aydınlatılamamıştır. Apelin, kan
basıncı regülasyonu ve vasküler fonksiyonları etkileyen,
ayrıca çeşitli fizyolojik görevleri olan bir peptittir.
Bu çalışmada, pre-eklampsi gelişiminde apelin-13’ün
rolünün olup olmadığını değerlendirmek amacıyla
normal ve erken başlangıçlı pre-eklampsili gebelerde,
plazma apelin-13 seviyeleri çalışıldı.
Gereç ve Yöntem
Bu vaka kontrol prospektif çalışma, Kadın Hastalıkları
ve Doğum Servisine başvuran gebelerin içerisinde
toplam 60 gebe çalışmaya dahil edildi. Projedeki
gruplar sağlıklı gebe kontrol (n:30) ve erken başlangıçlı
pre-eklampsi gebe (n:30) olarak dizayn edildi.
Erken başlangıçlı pre-eklampsi grubu 30. haftada
pre-eklampsi tanısı konan erken başlangıçlı pre-eklampsi
gebelerden oluşmakta idi. Katılımcılardan 30.
hafta alınan kan örneklerinden trombosit, serum albümin,
ALT, AST, üre, kreatinin ve plazma apelin-13
değerleri ölçüldü.
Bulgular
Sağlıklı gebe kontrollere göre, erken başlangıçlı
pre-eklampsi gebelerdeki trombosit, serum albümin,
seviyelerindeki azalma ve ALT, AST, üre ve kreatinin
parametrelerindeki artma, istatiksel değerlendirme
açısından anlamlı bulundu (p=0,011; p=0,001;
p=0,006; p=0,05; p=0,001; p=0,003; sırasıyla). Plazma
apelin-13 değeri sağlıklı ve erken başlangıçlı
pre-eklampsi gebeler arasında karşılaştırıldığında anlamlı
bir fark bulunmadı.
Sonuç
30. haftadan sonra gelişen erken başlangıçlı pre-eklampsinin
teşhisinde Apelin-13’ün tanısal değeri bulunmamaktadır.

Keywords

Apelin, Apelin 13, Gebelik, Hipertansiyon, Pre-eklampsi.

Supporting Institution

Necmettin Erbakan Üniversitesi Bilimsel Araştırma Projeleri Kordinatörlüğü

Project Number

Necmettin Erbakan Üniversitesi Bilimsel Araştırma Projeleri Kordinatörlüğü

INVESTIGATION OF THE RELATIONSHIP BETWEEN PLASMA APELIN LEVEL AND PRE-ECLAMPSIA CASES

Abstract

Objective
Pre-eclampsia, a multi-systemic disease that develops
during pregnancy, is a pathology that causes at
least 42.000 maternal deaths per year. Theories
regarding the pathophysiology of pre-eclampsia are
mainly based on maternal-fetal (paternal) immune
malperfusion, which is thought to be associated
with superficial placentation, and the cause of preeclampsia
has not yet been fully elucidated. Apelin is
a peptide that affects blood pressure regulation and
vascular functions, and also has various physiological
functions. In this study, plasma apelin-13 levels were
studied in normal and development of early-onset
pre-eclampsia pregnant women to evaluate whether
apelin-13 has a role in the development of early-onset
pre-eclampsia.
Material and Method
In this case-control prospective study, a total of 60
pregnant women who applied to the Obstetrics and
Gynecology Service were included in the study.
The groups in the project were designed as healthy
pregnant control (n: 30) and the development of
early-onset pre-eclampsia pregnant (n: 30). The
development of early-onset pre-eclampsia group
consisted of the development of early-onset preeclampsia
pregnant women diagnosed with preeclampsia
at the 30th week. Platelet, serum albumin,
ALT, AST, urea, creatinine and plasma apelin-13
values were measured from the blood samples taken
from the participants at the 30th week.
Results
Compared to healthy pregnant controls, the decreases
in platelet and serum albumin levels, and the increases
in ALT, AST, urea, and creatinine parameters in the
development of early-onset pre-eclampsia pregnant
women were statistically significant (p=0,011;
p=0,001; p=0,006; p=0,05; p=0,001; p=0,003;
respectively). When the plasma apelin-13 value was
compared between healthy and the development
of early-onset pre-eclampsia pregnant women, no
significant difference was found.
Conclusion
Apelin-13 has no diagnostic value in the diagnosis of
development of early-onset pre-eclampsia developing
after the 30th week.

Keywords

Apelin, Apelin 13, Hypertension, Preeclampsia, Pregnancy

Project Number

Necmettin Erbakan Üniversitesi Bilimsel Araştırma Projeleri Kordinatörlüğü

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