Öz

Valproik asit; epilepsi, bipolar bozukluk ve migren gibi hastalıkların tedavisinde kullanılır. Valproik asitin en sık görülen yan etkileri saç dökülmesi, gastrointestinal sistem ilişkili semptomlar ve kilo alımıdır. Akut karaciğer yetmezliği, pankreatit, kanama diyatezi, ensefalopati ciddi yan etkileridir. Valproat kullanan hastalarda periferik ödem gelişmesi nadir görülen bir yan etkidir. Çoğunlukla uzun dönem yan etkisi olarak görülmekle beraber, kısa dönem kullanımlarda da bildirilen vakalar mevcuttur. Akut başlayan periferik ödem, geniş ayrıcı tanı spektrumuyla kapsamlı araştırmayı gerektirir. Olgumuzda 16 yaşındaki erkek hastada akut alt ekstremite ödemi, valproik asit kullanımına bağlı nadir görülen ilaç yan etkisi olarak karşımıza çıkmıştır.

Anahtar Kelimeler

• valproik asit
• ödem
• yan etki

A Rare Side Effect of Valproic Acid Use: Edema

Öz

Valproic acid is used in the treatment of diseases such as epilepsy, bipolar disorder and migraine. The most common side effects of valproic acid are hair loss, gastrointestinal system-related symptoms and weight gain. Acute liver failure, pancreatitis, bleeding diathesis, and encephalopathy are serious side effects. Peripheral edema is a rare side effect in patients using valproate. Although it is mostly seen as a long-term side effect, there are also cases reported in short-term use. Acute onset peripheral edema requires comprehensive investigation with a wide spectrum of differential diagnosis. In our case, acute lower extremity edema in a 16-year-old male patient occurred as a rare drug side effect due to valproic acid use.

Anahtar Kelimeler

• valproic acid
• edema
• side effect

Kaynakça

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