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Yıl 2024, Cilt: 31 Sayı: 2, 191 - 193, 29.06.2024
https://doi.org/10.17343/sdutfd.1374953
https://izlik.org/JA32XK65NW

Öz

Valproik asit; epilepsi, bipolar bozukluk ve migren gibi hastalıkların tedavisinde kullanılır. Valproik asitin en sık görülen yan etkileri saç dökülmesi, gastrointestinal sistem ilişkili semptomlar ve kilo alımıdır. Akut karaciğer yetmezliği, pankreatit, kanama diyatezi, ensefalopati ciddi yan etkileridir. Valproat kullanan hastalarda periferik ödem gelişmesi nadir görülen bir yan etkidir. Çoğunlukla uzun dönem yan etkisi olarak görülmekle beraber, kısa dönem kullanımlarda da bildirilen vakalar mevcuttur. Akut başlayan periferik ödem, geniş ayrıcı tanı spektrumuyla kapsamlı araştırmayı gerektirir. Olgumuzda 16 yaşındaki erkek hastada akut alt ekstremite ödemi, valproik asit kullanımına bağlı nadir görülen ilaç yan etkisi olarak karşımıza çıkmıştır.

Kaynakça

  • 1.Prajapati H, Kansal D, Negi R. Magnesium Valproate-Induced Pedal Edema on Chronic Therapy: A rare Adverse Drug Reaction. Indian Journal of Pharmacology 2017;49(5):399.
  • 2.Lin S-T, Chen C-S, Yen C-F, Tsei J-H, Wang S-Y. Valproate-related peripheral oedema: A Manageable But Probably Neglected Condition. International Journal of Neuropsychopharmacology 2009;12(7):991-3.
  • 3.Chuang K, Patel S. Valproate-Induced Lower Extremity Swelling. Federal Practitioner 2020;37(8):388.
  • 4.Maneerot T, Jenraumjit R, Kijsawatpaiboon S, Reungyos J. Low-Dose Valproate-Related Peripheral Edema in Patients With Bipolar Disorder: Two Case Reports. Journal of Clinical Psychopharmacology 2019;39(4):412-3.
  • 5.Ettinger A, Moshe S, Shinnar S. Edema Associated with long‐Term Valproate Therapy. Epilepsia 1990;31(2):211-3.
  • 6.Haviv Y, Kuper A. Severe Peripheral Oedema Associated with Valproic Acid. Clinical Drug Investigation 2000;19:385-7.
  • 7.Zimmerman HJ, Ishak KG. Valproate‐Induced Hepatic Injury: Analyses of 23 Fatal Cases. Hepatology 1982;2(5):591S-7S.
  • 8.Mathew T, D'Souza D, Nadimpally US, Nadig R. Clobazam‐Induced Pedal Edema:“An Unrecognized Side Effect of a Common Antiepileptic Drug”. Epilepsia 2016;57(3):524-5.
  • 9.Bourin M, Chenu F, Hascoet M. The Role of Sodium Channels in the Mechanism of Action of Antidepressants and Mood Stabilizers. Current Drug Targets 2009;10(11):1052-60.
  • 10.Takemoto Y. Effects of Gamma‐Aminobutyric Acid on Regional Vascular Resistances of Conscious Spontaneously Hypertensive Rats. Clinical and Experimental Pharmacology and Physiology 1995;22:S102-Sl04.

A Rare Side Effect of Valproic Acid Use: Edema

Yıl 2024, Cilt: 31 Sayı: 2, 191 - 193, 29.06.2024
https://doi.org/10.17343/sdutfd.1374953
https://izlik.org/JA32XK65NW

Öz

Valproic acid is used in the treatment of diseases such as epilepsy, bipolar disorder and migraine. The most common side effects of valproic acid are hair loss, gastrointestinal system-related symptoms and weight gain. Acute liver failure, pancreatitis, bleeding diathesis, and encephalopathy are serious side effects. Peripheral edema is a rare side effect in patients using valproate. Although it is mostly seen as a long-term side effect, there are also cases reported in short-term use. Acute onset peripheral edema requires comprehensive investigation with a wide spectrum of differential diagnosis. In our case, acute lower extremity edema in a 16-year-old male patient occurred as a rare drug side effect due to valproic acid use.

Kaynakça

  • 1.Prajapati H, Kansal D, Negi R. Magnesium Valproate-Induced Pedal Edema on Chronic Therapy: A rare Adverse Drug Reaction. Indian Journal of Pharmacology 2017;49(5):399.
  • 2.Lin S-T, Chen C-S, Yen C-F, Tsei J-H, Wang S-Y. Valproate-related peripheral oedema: A Manageable But Probably Neglected Condition. International Journal of Neuropsychopharmacology 2009;12(7):991-3.
  • 3.Chuang K, Patel S. Valproate-Induced Lower Extremity Swelling. Federal Practitioner 2020;37(8):388.
  • 4.Maneerot T, Jenraumjit R, Kijsawatpaiboon S, Reungyos J. Low-Dose Valproate-Related Peripheral Edema in Patients With Bipolar Disorder: Two Case Reports. Journal of Clinical Psychopharmacology 2019;39(4):412-3.
  • 5.Ettinger A, Moshe S, Shinnar S. Edema Associated with long‐Term Valproate Therapy. Epilepsia 1990;31(2):211-3.
  • 6.Haviv Y, Kuper A. Severe Peripheral Oedema Associated with Valproic Acid. Clinical Drug Investigation 2000;19:385-7.
  • 7.Zimmerman HJ, Ishak KG. Valproate‐Induced Hepatic Injury: Analyses of 23 Fatal Cases. Hepatology 1982;2(5):591S-7S.
  • 8.Mathew T, D'Souza D, Nadimpally US, Nadig R. Clobazam‐Induced Pedal Edema:“An Unrecognized Side Effect of a Common Antiepileptic Drug”. Epilepsia 2016;57(3):524-5.
  • 9.Bourin M, Chenu F, Hascoet M. The Role of Sodium Channels in the Mechanism of Action of Antidepressants and Mood Stabilizers. Current Drug Targets 2009;10(11):1052-60.
  • 10.Takemoto Y. Effects of Gamma‐Aminobutyric Acid on Regional Vascular Resistances of Conscious Spontaneously Hypertensive Rats. Clinical and Experimental Pharmacology and Physiology 1995;22:S102-Sl04.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Nörolojisi
Bölüm Olgu Sunumu
Yazarlar

Merve Büyükbayram 0000-0001-7998-9656

İbrahim Cemal Maslak 0000-0001-9708-5490

Gönderilme Tarihi 13 Ekim 2023
Kabul Tarihi 17 Ocak 2024
Yayımlanma Tarihi 29 Haziran 2024
DOI https://doi.org/10.17343/sdutfd.1374953
IZ https://izlik.org/JA32XK65NW
Yayımlandığı Sayı Yıl 2024 Cilt: 31 Sayı: 2

Kaynak Göster

Vancouver 1.Merve Büyükbayram, İbrahim Cemal Maslak. A Rare Side Effect of Valproic Acid Use: Edema. SDÜ Tıp Fak Derg. 01 Haziran 2024;31(2):191-3. doi:10.17343/sdutfd.1374953

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