The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Yıl 2024, Cilt: 31 Sayı: 4, 332 - 338, 26.12.2024

Adem Milletsever , Abdurrahman Gülal , Halil Aşçı

https://doi.org/10.17343/sdutfd.1514644

https://izlik.org/JA56HK29PG

Öz

Objective: Chest trauma-induced brain injury (CTBI) is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol (CBD), a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI.
Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI (200 g weight drop on the anterior chest wall from a height of 1 meter), CTBI+CBD (5 mg/kg, single dose intraperitoneally), and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10% formaldehyde solution for histopathological and immunohistochemical examination.
Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions.
Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

Anahtar Kelimeler

Blunt chest trauma , brain , cannabidiol , apoptosis , malondialdehyde

Etik Beyan

The study was carried out at Süleyman Demirel University Experimental Animal Production and Experimental Research Laboratory. Ethical approval was obtained from the National Institutes of Health and approved by the Local Ethics Committee for Animal Experiments of Suleyman Demirel University (Approval No. 2023-01/116).

Destekleyen Kurum

This study was supported by the project coded "TSG-2023-9010," funded by the Scientific Research Coordination Unit of Süleyman Demirel University.

Proje Numarası

TSG-2023-9010

Teşekkür

None.

Kaynakça

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