Mitochondria and Cancer

Gizel Gerdan; Şirin Kılıçturgay Yüksel; Cemaliye Boylu Akyerli

doi:10.17343/sdutfd.1562838

EN

Mitochondria and Cancer

Öz

Mitochondria generate energy through cellular respiration and regulate various cellular processes such as heat production, generation and detoxification of reactive oxygen species, metabolism, apoptosis, and calcium homeostasis. In human cells, large numbers of mitochondria are present, each containing multiple copies of mitochondrial DNA. Variations in mitochondrial DNA have been associated with the onset and progression of various diseases, including neurological, cardiovascular, and metabolic disorders and also several cancers. These variants can be important drivers of cancer and may play a crucial role in tumor development. Additionally, mitochondrial copy number changes and structural variations, such as deletions can be associated with different types of cancer. Therefore, understanding the fundamental mechanisms is highly crucial. The molecular genetic correlations of mitochondrial DNA alterations and cancer, emphasize the importance of mitochondrial integrity in maintaining cellular homeostasis. Gaining knowledge of these associations can help us comprehend cancer processes as well as potential routes for targeted treatments and prevention, while further investigation is still required.

Anahtar Kelimeler

Etik Beyan

The ethical approval is not required. This article does not contain any studies with human or animal subjects.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Kanser Genetiği, Kanser Hücre Biyolojisi

Bölüm

Derleme

Yazarlar

Gizel Gerdan
0009-0001-5886-3269
Türkiye

Şirin Kılıçturgay Yüksel
0000-0002-7130-2933
Türkiye

Cemaliye Boylu Akyerli ^*
0000-0002-7263-2969
Türkiye

Erken Görünüm Tarihi

19 Şubat 2025

Yayımlanma Tarihi

27 Mart 2025

Gönderilme Tarihi

7 Ekim 2024

Kabul Tarihi

23 Aralık 2024

Yayımlandığı Sayı

Yıl 2025 Cilt: 32 Sayı: 1

DOI

https://doi.org/10.17343/sdutfd.1562838

IZ

https://izlik.org/JA37XZ69WP

Kaynak Göster

RIS / Bibtex

APA

Gerdan, G., Kılıçturgay Yüksel, Ş., & Boylu Akyerli, C. (2025). Mitochondria and Cancer. Medical Journal of Süleyman Demirel University, 32(1), 95-106. https://doi.org/10.17343/sdutfd.1562838

AMA

1.Gerdan G, Kılıçturgay Yüksel Ş, Boylu Akyerli C. Mitochondria and Cancer. SDÜ Tıp Fak Derg. 2025;32(1):95-106. doi:10.17343/sdutfd.1562838

Chicago

Gerdan, Gizel, Şirin Kılıçturgay Yüksel, ve Cemaliye Boylu Akyerli. 2025. “Mitochondria and Cancer”. Medical Journal of Süleyman Demirel University 32 (1): 95-106. https://doi.org/10.17343/sdutfd.1562838.

EndNote

Gerdan G, Kılıçturgay Yüksel Ş, Boylu Akyerli C (01 Mart 2025) Mitochondria and Cancer. Medical Journal of Süleyman Demirel University 32 1 95–106.

IEEE

[1]G. Gerdan, Ş. Kılıçturgay Yüksel, ve C. Boylu Akyerli, “Mitochondria and Cancer”, SDÜ Tıp Fak Derg, c. 32, sy 1, ss. 95–106, Mar. 2025, doi: 10.17343/sdutfd.1562838.

ISNAD

Gerdan, Gizel - Kılıçturgay Yüksel, Şirin - Boylu Akyerli, Cemaliye. “Mitochondria and Cancer”. Medical Journal of Süleyman Demirel University 32/1 (01 Mart 2025): 95-106. https://doi.org/10.17343/sdutfd.1562838.

JAMA

1.Gerdan G, Kılıçturgay Yüksel Ş, Boylu Akyerli C. Mitochondria and Cancer. SDÜ Tıp Fak Derg. 2025;32:95–106.

MLA

Gerdan, Gizel, vd. “Mitochondria and Cancer”. Medical Journal of Süleyman Demirel University, c. 32, sy 1, Mart 2025, ss. 95-106, doi:10.17343/sdutfd.1562838.

Vancouver

1.Gizel Gerdan, Şirin Kılıçturgay Yüksel, Cemaliye Boylu Akyerli. Mitochondria and Cancer. SDÜ Tıp Fak Derg. 01 Mart 2025;32(1):95-106. doi:10.17343/sdutfd.1562838