Araştırma Makalesi

Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis

Cilt: 32 Sayı: 1 27 Mart 2025
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Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis

Öz

Objective: Identifying modifiable risk factors is very important for preventing acute chronic obstructive pulmonary disease (COPD) severity. This study was conducted to determine the role of serum magnesium levels in acute COPD exacerbation. Material and Method: A total of 104 COPD patients with a mean age of 66.63 ± 8.79 years and female 17.3%(18) males 82.69%(86) were included in our study. Chest X-ray, respiratory function test, and biochemical blood tests were performed on the cases. The relationship between magnesium level and COPD severity was evaluated using appropriate statistical methods. Results: Demographic data of the patients were collected, biochemical evaluation was performed, and the relationship between magnesium levels and respiratory parameters was investigated. Serum magnesium was found to be low in patients (25%). COPD evaluation test was compared with mMMR and CAT, dyspnea symptoms were observed to be more in hypomagnesemia cases, and the difference was found to be statistically significant (p:0.029, p:0.030, respectively). In terms of respiratory function tests, FEF25-75 was found to be lower and statistically significant in hypomagnesemia patients. Disease duration was found to be statistically significant in hypomagnesemia cases (p:0.033). When compared with male and female patients, smoking was observed more in male individuals, and this parameter was also found to be statistically significant (p:0.044). Conclusion: It was concluded that hypomagnesemia may increase respiratory distress in COPD patients and contribute to COPD exacerbations.

Anahtar Kelimeler

Etik Beyan

Ethics Committee approval for this study was obtained from Harran University, as evidenced by a letter dated 12.12.2022- HRÜ/22.24.28. This study was conducted in accordance with the principles outlined in the Declaration of Helsinki.

Kaynakça

  1. 1. Christenson SA, Smith BM, Bafadhel M, et al. Chronic obstructive pulmonary disease. Lancet 2022;399(10342):2227–42.
  2. 2. Buist AS, McBurnie MA, Vollmer WM, et al. International variation in the prevalence of COPD (the BOLD study): a population-based prevalence study. Lancet 2007(9)1;370(9589):741-50.
  3. 3. Kahnert K, Jörres RA, Behr J, et al. The diagnosis and treatment of COPD and its Comorbidities. Dtsch Arztebl Int 2023 Jun 23;120(25):434-444.
  4. 4. Holtjer JCS, Bloemsma LD, Beijers et al. Identifying risk factors for COPD and adult- ons et asthma: an umbrella review. Eur Respir Rev 2023;(5) 32:168.
  5. 5. Ye M, Li Q, Xiao L, et al. Serum magnesium and fractional exhaled nitric oxide in relation to the severity in asthma-chronic obstructive pulmonary disease overlap. Biol Trace Elem Res 2021;199(5):1771-1777.
  6. 6. Ni H, Aye SZ, Naing C. Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2022; 26:5(5)CD013506.
  7. 7. De Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: Implications for health and disease. Physiol Rev 2015;95(1):1-46.
  8. 8. Gourgoulianis KI, Chatziparasidis G, Chatziefthimiou A et al. Magnesium as a relaxing factor of airway smooth muscles. J Aerosol Med 2001;14(3):301-7.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Solunum Hastalıkları

Bölüm

Araştırma Makalesi

Erken Görünüm Tarihi

27 Mart 2025

Yayımlanma Tarihi

27 Mart 2025

Gönderilme Tarihi

22 Kasım 2024

Kabul Tarihi

27 Ocak 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 32 Sayı: 1

Kaynak Göster

APA
Mutlu Hayat, İ., & Günak, F. (2025). Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis. Medical Journal of Süleyman Demirel University, 32(1), 81-87. https://doi.org/10.17343/sdutfd.1589701
AMA
1.Mutlu Hayat İ, Günak F. Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis. SDÜ Tıp Fak Derg. 2025;32(1):81-87. doi:10.17343/sdutfd.1589701
Chicago
Mutlu Hayat, İmren, ve Faruk Günak. 2025. “Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis”. Medical Journal of Süleyman Demirel University 32 (1): 81-87. https://doi.org/10.17343/sdutfd.1589701.
EndNote
Mutlu Hayat İ, Günak F (01 Mart 2025) Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis. Medical Journal of Süleyman Demirel University 32 1 81–87.
IEEE
[1]İ. Mutlu Hayat ve F. Günak, “Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis”, SDÜ Tıp Fak Derg, c. 32, sy 1, ss. 81–87, Mar. 2025, doi: 10.17343/sdutfd.1589701.
ISNAD
Mutlu Hayat, İmren - Günak, Faruk. “Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis”. Medical Journal of Süleyman Demirel University 32/1 (01 Mart 2025): 81-87. https://doi.org/10.17343/sdutfd.1589701.
JAMA
1.Mutlu Hayat İ, Günak F. Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis. SDÜ Tıp Fak Derg. 2025;32:81–87.
MLA
Mutlu Hayat, İmren, ve Faruk Günak. “Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis”. Medical Journal of Süleyman Demirel University, c. 32, sy 1, Mart 2025, ss. 81-87, doi:10.17343/sdutfd.1589701.
Vancouver
1.İmren Mutlu Hayat, Faruk Günak. Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis. SDÜ Tıp Fak Derg. 01 Mart 2025;32(1):81-7. doi:10.17343/sdutfd.1589701

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