The Relationship of Leptin, Obesity, and Exercise: A Systematic Review

Yıl 2026, Cilt: 33 Sayı: 1, 103 - 113, 21.03.2026

Hilal Demiralay

https://doi.org/10.17343/sdutfd.1628367

https://izlik.org/JA23WF99NU

Öz

Obesity and obesity-related diseases have become a rapidly increasing important health problem. Hormones such as leptin, ghrelin, obestatin, and nesfatin-1 play an important role in fat tissue accumulation and the appetite mechanism. Leptin belongs to a class of hormones known as adipocytokines, which play a role in regulating energy metabolism. This study aimed to investigate the relationships between leptin, obesity, and exercise. This study analyses the relationship of leptin, obesity, and exercise using the Preferred Reporting Items for Systematic Reviews. We conducted this systematic review following the PRISMA 2020 statement. The systematic review used a search to identify studies published in PubMed, Wiley Online Library, EBSCO, Science Direct, and Web of Science databases. In this study, the relationships between leptin, obesity and exercise were investigated. A total of 1022 records were initially scoped in the literature search, 784 of which were duplicates. After screening for eligibility and inclusion criteria, 57 articles were ultimately included in the study. Hormones, which are thought to be the source of obesity, are the focus of current studies. Studies have shown that maintaining certain circulating leptin concentrations is essential. Studies have shown a positive relationship between leptin levels and serum fasting insulin and insulin resistance in obese individuals. It also shows that insulin resistance is associated with leptin and adiponectin. There are studies showing that exercise decreases leptin concentration. The discrepancies in the results of studies examining the effect of exercise on the leptin response may arise from many methodological differences, such as the intensity, duration, frequency, and scope of exercise, the nutritional status of the participants, and the time and frequency of sampling. This review shows that chronic exercise interventions consistently reduce leptin concentrations, mostly mediated by fat mass loss. Acute effects are inconsistent and often delayed. Prolonged strenuous exercise leads to marked decreases. Future research should standardize leptin measurement, incorporate biomarkers such as soluble leptin receptor and adiponectin, and explore leptin-targeted therapies in obesity treatment.

Anahtar Kelimeler

Exercise , Leptin , Obesity

Etik Beyan

No ethical clearance was required for this systematic review.

Destekleyen Kurum

This research did not receive any specific grant from funding agencies in the public, commercial, or not-forprofit sectors.

Kaynakça

• 1. Monica B, Silvia G, Simone R, Alessendro A, Silke M, Federica D, et al. Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior. BMC Med 2022;20(500):1-25.
• 2. Şahin T, Tozcu D. Leptin, Mikrobiyota ve Obezite İlişkisi. Türkiye Diyabet ve Obezite Dergisi 2022; 6(1):77-84.
• 3. Barness LA, Opitz, J M, & Gilbert‐Barness, E. Obesity: genetic, molecular, and environmental aspects. American journal of medical genetics part A 2007;143(24):3016-3034.
• 4. Oswal A, Yeo G. Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity. Obesity 2010;18:221–229.
• 5. Khan M, Joseph F. Adipose Tissue and Adipokines: The Association with and Application of Adipokines in Obesity. Science 2014;1:328-592.
• 6. Genchi VA, D’Oria R, Palma G, Caccioppoli C, Cignarelli A, Natalicchio A, et al. Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine? International Journal of Molecular Sciences 2021; 22(12): 6445.
• 7. Ayvalı Z, Yakan B, Deniz K. Sleeve Gastrektomi Uygulanmış Obezite Hastalarında Ghrelin, Obestatin, Leptin Ekspreyonları’nın Araştırılması. Sağlık Araştırmaları Dergisi (Tusad) 2024;1(2):80-98.
• 8. Hekimoğlu A. Leptin ve fizyopatolojik olaylardaki rolü. Dicle Tıp Dergisi 2006;33(4): 259-267.
• 9. Friedman JM. The Function of Leptin in Nutrition, Weight, and Physiology. Nutrition Reviews 2002; 60(10):1-14.
• 10. Farooqi IS, Wangensteen T, Collins S. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007;356:237–247.
• 11. Calabro P, Limongelli G, Pacileo G, Salvo GD, Golino P, Calabro R. The role of adiposity as a determinant of an inflammatory milieu. J Cardiovasc Med 2007;8:1-11.
• 12. Bulduk B, Günbatar N. The Effect of Exercise on Serum Resistin and Leptin Values in Rats Fed with a High Fat Diet. Journal of Contemporary Medicine 2023;13(1):82-85.
• 13. Fried SK, Ricci MR, Russell CD, Laferrère B. Regulation of leptin production in humans. J Nutr 2000;130(12):3127-3131.
• 14. Erçakır M, Bayram S. Obez Bireylerde Serum Ferritin Düzeyleri, İnsülin Direnci, Metabolik Sendrom ve Beslenme Durumları Arasındaki İlişkinin Retrospektif Analizi. Gazi Sağlık Bilimleri Dergisi 2022;7(2):90-102.
• 15. Koch CE, Lowe C, Pretz D, Steger J, Williams LM, Tups A. High-fat diet induces leptin resistance in leptin-deficient mice. J Neuroendocrinol 2014; 26(2):58-67.
• 16. Major GC, Doucet E, Trayhurn P, Astrup A, Tremblay A. Clinical significance of adaptive thermogenesis. International Journal of Obesity 2007;31(2):204-212.
• 17. Imbeault P, Doucet E, Mauriège P, St-Pierre S, Couillard C, Alméras N, et al. Difference in leptin response to a high-fat meal between lean and obese men. Clin Sci (Lond) 2001;101(4):359-365.
• 18. Kord HV, Tinsley GM, Santos HO, Zand H, Nazary A, Fatahi S, et al. The influence of fasting and energy-restricted diets on leptin and adiponectin levels in humans: a systematic review and meta-analysis. Clinical Nutrition 2021;40(4):1811-1821.
• 19. Myers MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology and Metabolism 2010;21(11):643-651.
• 20. Kıvrak EG, Aydın I, Tümentemur G, Altunkaynak BZ, Kaplan S. Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats. Journal of Experimental and Clinical Medicine 2013;30(2):141-145.
• 21. Pospiech E. Leptin: The Satiety Hormone and its Influence on Obesity. Eukaryon 2010;6:80-83.
• 22. Özen Ş, Özen G. Leptin Hormonu: Egzersiz ve Obezite ile İlişkisi. New World Sciences Academy 2011;6(2):114-127.
• 23. Obradovic M. Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, Isenovic ER. Leptin and obesity: role and clinical implication. Frontiers in endocrinology 2021;12:585887.
• 24. Gültürk S, Demirkazık A. Leptin ve Diyabet. Cumhuruyet Üniversitesi Tıp Fakültesi Dergisi 2007;29(1):35-40.
• 25. Söylemez N, Demirbağ R, Sezen Y, Yıldız A, Akpınar O. Vücut kütle indeksine göre leptin ve adiponektin seviyeleri ve bunların oksidatif parametrelerle ilişkisi. Anadolu Kardiyol Derg 2010;10:391-396.
• 26. Yiğitbaşı T, Baskın Y, Afacan G, Harmanda A. Relationship Between The Levels of Growth Hormone, Leptin, Amylin, Glucagon Like Peptide-1 and Insulin Resistance in Obese Patients. Turk J Biochem 2010;35(3):177–182.
• 27. Frühbeck G, Salvador J. Relation between leptin and the regulation of glucose metabolism. Diabetologia 2000;43:3-12.
• 28. Üçok K, Gökbel H. Egzersizin leptin düzeylerine etkileri. Genel Tıp Derg 2004;14(3):121-124.
• 29. Reseland JE, Anderssen SA, Solvoll K, Hjermann I, Urdal P, Holme I, Drevon CA. Effect of long-term changes in diet and exercise on plasma leptin concentrations. Am J Clin Nutr 2001;73:240–245.
• 30. Ergün, A. Leptin (ob protein). Turkiye Klinikleri Journal of Medical Sciences 1999; 19(2):130-136.
• 31. Lönnerdal B, Havel PJ. Serum leptin concentrations in infants: effects of diet, sex, and adiposity. Am J Clin Nutr 2000;72:484–489.
• 32. Singhal A, Farooqi S, O’Rahilly S, Cole TJ, Fewtrell M, Lucas A. Early nutrition and leptin concentrations in later life. Am J Clin Nutr 2002;75:993–999.
• 33. Torjman MC. On the delayed effects of exercise on leptin: More questions than answers. Nutrition 2001;17(5):420-422.
• 34. Weltman A, Pritzlaff CR, Wideman L, Considine RV, Fryburg DA, Gutgesell ME, et al. Intensity of acute exercise does not affect serum leptin concentrations in young men. Med Sci Sports Exerc 2000;32:1556-61.
• 35. Olive JL, Miller MS, Miller GD. Differential effects of maximaland moderate- intensity runs on plasma leptin in healthy trained subjects. Nutrition 2001;17:365-9.
• 36. Kraemer RR, Johnson LG, Haltom R, Kraemer GR, Hebert EP, Gimpel T, et al. Serum leptin concentrations in response to acute exercise in postmenopausal women with and without hormone replacement therapy. Proc Soc Exp Biol Med 1999;221:171-7.
• 37. Torjman MC, Zafeiridis A, Paolone AM, Wilkerson C, Considine RV. Serum leptin during recovery following maximal incremental and prolonged exercise. Int J Sports Med 1999;20:444-50.
• 38. Svensson J, Herlitz H, Lundberg PA, Johannsson G. Adiponectin, leptin, and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient adults. The Journal of Clinical Endocrinology Metabolism 2005;90(4):2290-2296.
• 39. Kraemer RR, Acevedo EO, Synovitz LB, Hebert EP, Gimpel T, Castracane VD. Leptin and steroid hormone responses to exercise in adolescent female runners over a 7-week season. Eur J Appl Physiol 2001;86:85-91.
• 40. Hulver M, Houmard J. Plasma leptin and exercise: Recent findings. Sports Med 2003;33:473-82.
• 41. Essig DA, Alderson NL, Ferguson MA, Bartoli WP, Durstine JL. Delayed effects of exercise on the plasma leptin concentration. Metabolism 2000;49:395-9.
• 42. Karamouzis I, Karamouzis M, Vrabas IS, Christoulas K, Kyriazis N, Giannoulis E, et al. The effects of marathon swimming on serum leptin and plasma neuropeptide Y levels. Clin Chem Lab Med 2002;40:132-6.
• 43. Fan S, Xu Y, Lu Y, Jiang Z, Li H, Morrill JC, et al. A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia. Nature communications 2021;12(1):2662.
• 44. Poggi AI, Andreasen MW, Sahl RE, Hansen MT, et al. Effect of repeated prolonged exercise on liver fat content and visceral adipose tissue in well‐trained older men. Scandinavian Journal of Medicine & Science in Sports 2024;34(4):14612.
• 45. Gökbel H, Baltaci AK., Üçok K. Okudan N, & Moĝulkoç R. Changes in serum leptin levels in strenuous exercise and its relation to zinc deficiency in rats. Biological Trace Element Research 2005;106:247-252.
• 46. Ayvalı Z, Yakan B, Deniz K. Sleeve Gastrektomi Uygulanmış Obezite Hastalarında Ghrelin, Obestatin, Leptin Ekspreyonları’nın Araştırılması. Sağlık Araştırmaları Dergisi 2024;1(2):80-98.
• 47. Kraemer RR, Chu H, Castracane VD. Leptin and exercise. Exp Biol Med 2002;227:701-8.
• 48. Houmard JA, Cox JH, MacLean PS, Barakat HA. Effect of short-term exercise training on leptin and insulin action. Metabolism 2000;49:858-61.
• 49. Zheng D, Wooter MH, Zhou Q, Dohm GL. The effect of exercise on ob gene expression. Biochem Biophys Res Commun 1996;225:747-50.
• 50. Leal-Cerro A, Garcia-Luna PP, Astorga R, Parejo J, Peino R, Dieguez C, et al. Serum leptin levels in male marathon athletes before and after the marathon run. J Clin Endocrinol Metab 1998;83:2376-9.
• 51. Dirlewanger M, Di Vetta V, Giusti V, Schneiter P, Jéquier E, Tappy L. Effect of moderate physical activity on plasma leptin concentration in humans. Eur J Appl Physiol 1999;79:331-5.
• 52. Kraemer RR, Kraemer GR, Acevedo EO, Hebert EP, Tample E, Bates M, et al. Effects of aerobic exercise on serum leptin levels in obese women. Eur J Appl Physiol 1999;80:154-8.
• 53. Noland RC, Baker JT, Boudreau SR, Kobe RW, Tanner CJ, Hickner RC, et al. Effect of intense training on plasma leptin in male and female swimmers. Med Sci Sports Exerc 2001;33:227-31.
• 54. Gomez-Merino D, Chennaoui M, Drogou C, Bonneau D, Guezennec CY. Decrease in serum leptin after prolonged physical activity in men. Med Sci Sports Exerc 2002;34:1594-9.
• 55. Okazaki T, Himeno E, Nanri H, Ogata H, Ikeda M. Effects of mild aerobic exercise and a mild hypocaloric diet on plasma leptin in sedentary women. Clin Exp Pharmacol Physiol 1999;26:415-20.
• 56. Mitoiu BI, Nartea R, Miclaus RS. Impact of resistance and endurance training on ghrelin and plasma leptin levels in overweight and obese subjects. International Journal of Molecular Sciences 2024;25(15):8067.
• 57. Gutin B, Ramsey L, Barbeau P, Cannady W, Ferguson,M, Litaker M, & Owens S. Plasma leptin concentrations in obese children: changes during 4-mo periods with and without physical training. The American journal of clinical nutrition 1999;69(3):388-394.
• 58. Ünal M, Ünal DÖ, Baltacı AK, Moğulkoç R, Yıldız S, Kayserilioğlu A. Erkek profesyonel futbolcular ve sağlıklı sedanter erkeklerde serum leptin seviyelerinin incelenmesi. I. Leptin Sempozyumu. Konya; 20-22 Haziran 2003
• 59. Kanaley JA, Fenicchia LM, Miller CS, Ploutz-Synder LL, Weinstock RS, Carhard R, et al. Resting leptin responses to acute and chronic resistance training in type 2 diabetic men and women. Int J Obes 2001;25:1474-80.
• 60. Nindl BC, Kraemer WJ, Arciero PJ, Samatallee N, Leone CD, Mayo MF, et al. Leptin concentrations experience a delayed reduction after resistance exercise in men. Med Sci Sports Exerc 2002;34:608-13.