Basal Cell Carcinoma Arising from a Port Wine Stain

Yıl 2025, Cilt: 32 Sayı: 3, 240 - 243, 09.09.2025

Yunus Başar , Baran Can İnce , Enver Arpaci

https://doi.org/10.17343/sdutfd.1656134

https://izlik.org/JA73ZP64WK

Öz

Objective: In this study, we present the diagnosis, clinical approach, and treatment process of BCC developing from the PWS background.
Material and Methods: This study is a case report of a patient who applied to our clinic in March 2023.
Results: Most of the BCCs appear in people over the age of 50 and those who have a long exposure to the sun. It’s possible to cure it with local wide surgical excision and adjuvant treatment. It has been documented in case reports that this phenomenon arises from PWS, which is a congenital vascular malformation.
Conclusions: Topical or radiation therapy that we use while treating various skin diseases can also increase the risk of BCC. The following presentation outlines the approach and treatment algorithm for BCC developing on the former known PWS.

Anahtar Kelimeler

Basal cell carcinoma , hemangioma , port wine strain , skin tumor

Etik Beyan

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Kaynakça

• 1. Marzuka AG, Book SE. Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management. Yale J Biol Med 2015;88:167-79. PMID: 26029015; PMCID: PMC4445438.
• 2. Fagan J, Brooks J, Ramsey ML. Basal Cell Cancer. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [cited 2023 Apr 14]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470301/
• 3. Yu M, Zloty D, Cowan B, Shapiro J, Haegert A, Bell RH, et al. Superficial, nodular, and morpheiform basal-cell carcinomas exhibit distinct gene expression profiles. J Invest Dermatol 2008;128:1797-805. https://doi.org/10.1038/sj.jid.5701243
• 4. Lashway SG, Worthen ADM, Abuasbah JN, et al. A meta-analysis of sunburn and basal cell carcinoma risk. Cancer Epidemiol 2023;85:102379. https://doi.org/10.1016/j.canep.2023.102379
• 5. Heath MS, Bar A. Basal cell carcinoma. Dermatol Clin 2023;41:13-21. https://doi.org/10.1016/j.det.2022.07.005
• 6. Castori M, Morrone A, Kanitakis J, Grammatico P. Genetic skin diseases predisposing to basal cell carcinoma. Eur J Dermatol 2012;22:299-309. https://doi.org/10.1684/ejd.2011.1633
• 7. Marangi GF, Segreto F, Bonetti MA, et al. Basal cell carcinoma arising within a port-wine stain. Int J Dermatol 2022;61:269-70. https://doi.org/10.1111/ijd.15944
• 8. Lapidoth M, Ad El D, David M, Alcalay J, Azaria R. Basal cell carcinoma arising over facial port wine stain: A single-centre experience. J Eur Acad Dermatol Venereol 2006;20:1066-9. https://doi.org/10.1111/j.1468-3083.2006.01701.x
• 9. Sánchez Espino LF, Ivars M, Antoñanzas J, Baselga E. Sturge-Weber syndrome: A review of pathophysiology, genetics, clinical features, and current management approaches. Appl Clin Genet 2023;16:63-81. https://doi.org/10.2147/TACG.S363685
• 10. Chlebicka I, Stefaniak A, Bieniek A, Szepietowski JC. Basal cell carcinoma arising in port wine stains: Coincidence or correlation? Adv Dermatol Allergol 2020;37(2):272-3. https://doi.org/10.5114/ada.2020.96245
• 11. Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, et al. Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 2013;368(21):1971-9. https://doi.org/10.1056/NEJMoa1213507. PMID: 23656586; PMCID: PMC3749068.
• 12. Jasim ZF, Woo WK, Walsh MY, Handley JM. Multifocal basal cell carcinoma developing in a facial port wine stain treated with argon and pulsed dye laser: A possible role for previous radiotherapy. Dermatol Surg 2004;30:1155-7. https://doi.org/10.1111/j.1524-4725.2004.30345.x