Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler

İsmail Yılmaz

doi:10.17343/sdutfd.64412

Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler

Öz

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2007 Mart; 14(1) Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler İsmail Yılmaz İzmir Eğitim ve Uygulama Hastanesi, Bozyaka\ İzmir Özet Minosiklin ve doksisiklin yüksek lipofilik özellikli ikinci jenerasyon tetrasiklinlerdir ve her iki ilaç da kan-beyin engelini kolayca geçebilir. Bu ilaçların antimikrobiyal özelliklerinden tamamen ayrı bir şekilde anti-inflamatuar özellliklerinin de bulunduğu belirlenmiştir. Yakın zaman önce yapılan çalışmalar minosiklinde daha belirgin olmak üzere ikinci jenerasyon tetrasiklinlerin global ve fokal beyin iskemisinde, Huntington hastalığında, amyotrofik lateral sklerozda, Parkinson hastalığında, multiple sklerozda, travmatik beyin hasarı ve medulla spinalis zedelenmesinde nöroprotektif etkileri olduğunu ortaya koymuştur. Nöroprotektif özellikte başta mikrogliyal aktivasyonun inhibisyonu olmak üzere anti-apopitotik ve anti-inflamatuar etkinliğin önemli rolü vardır. Bu bilgilerin daha fazla sayıda deneysel ve klinik çalışmalarla desteklenmesi, nöronal ölümle giden bir çok serebral hastalıkta başta minosiklin olmak üzere bu ilaçların güvenli bir şekilde kullanımına ışık tutacaktır. Anahtar kelimeler: Minosiklin, doksisiklin, nöroprotektif tedavi Abstract Second generation tetracyclines:A novel drug target for the neuroprotective therapy Minocycline and doxycycline are second generation tetracyclines that have high lipophilic properties and degree of access to brain. These drugs have antiinflammatory properties independent of their antimicrobial activities. Recently, it has been shown that these drugs (especially minocycline) display neuroprotective activity in animal models of global and focal cerebral ischemia, Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, traumatic brain injury and spinal cord injury. Mainly microglial activation's inhibition, then, antiapoptotic activity and antiinflammatory activity play an important role on neuroprotection's features. To support these information by more clinical and experimental studies light the way for second generation tetracyclines, especially minocycline in cerebral diseases with neuronal death. Key words: Minocycline, doxycycline, neuroprotection

Anahtar Kelimeler

Minosiklin, doksisiklin, nöroprotektif tedavi

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

İsmail Yılmaz

Yayımlanma Tarihi

30 Nisan 2009

Gönderilme Tarihi

30 Nisan 2009

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2007 Cilt: 14 Sayı: 1

DOI

https://doi.org/10.17343/sdutfd.64412

IZ

https://izlik.org/JA56GL35SH

Kaynak Göster

RIS / Bibtex

APA

Yılmaz, İ. (2009). Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler. Medical Journal of Süleyman Demirel University, 14(1), 47-52. https://doi.org/10.17343/sdutfd.64412

AMA

1.Yılmaz İ. Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler. SDÜ Tıp Fak Derg. 2009;14(1):47-52. doi:10.17343/sdutfd.64412

Chicago

Yılmaz, İsmail. 2009. “Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler”. Medical Journal of Süleyman Demirel University 14 (1): 47-52. https://doi.org/10.17343/sdutfd.64412.

EndNote

Yılmaz İ (01 Nisan 2009) Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler. Medical Journal of Süleyman Demirel University 14 1 47–52.

IEEE

[1]İ. Yılmaz, “Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler”, SDÜ Tıp Fak Derg, c. 14, sy 1, ss. 47–52, Nis. 2009, doi: 10.17343/sdutfd.64412.

ISNAD

Yılmaz, İsmail. “Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler”. Medical Journal of Süleyman Demirel University 14/1 (01 Nisan 2009): 47-52. https://doi.org/10.17343/sdutfd.64412.

JAMA

1.Yılmaz İ. Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler. SDÜ Tıp Fak Derg. 2009;14:47–52.

MLA

Yılmaz, İsmail. “Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler”. Medical Journal of Süleyman Demirel University, c. 14, sy 1, Nisan 2009, ss. 47-52, doi:10.17343/sdutfd.64412.

Vancouver

1.İsmail Yılmaz. Nöroprotektif tedavide yeni bir ilaç hedefi: İkinci jenerasyon tetrasiklinler. SDÜ Tıp Fak Derg. 01 Nisan 2009;14(1):47-52. doi:10.17343/sdutfd.64412