Relation between chronic prostatitis and prostate cancer

Öz

The mechanism and etiology of prostate cancer development has not been clearly established up to date. The discovery of prostate specific antigen (PSA) has become a cornerstone in the prostate cancer diagnosis. PSA is an important organ specific tumor marker, however, it is not cancer specific. It is well known that hystopathologic changes develop in tissues where inflammation occurs. Infection and inflammation are complex response in which several pathways play role and some of these pathways are activated during the cancer process, as well. Chronic inflammation and chronic infections play important role in carcinogenesis of various organ (such as bladder, liver, colon, esophagus and stomach) and are considered to be etiologic
factors in about 20% of cancers. Epidemiologic, hystologic and genetic studies suggests that there may be a relation between common conditions such as prostatitis and prostate cancer. As a conclusion, the conditions that trigger and sustain the inflammatory process may be very important for prostatic carcinogenesis.

Anahtar Kelimeler

• Chronic prostatitis
• prostate cancer
• inflamation
• tissue damage

Prostat Kanseri Gelişimi İçin Kronik prostatit Bir Risk Faktörü müdür?

Öz

Bu güne kadar prostat kanseri gelişimine sebep olabilecek nedenler ve mekanizmalar bütün açıklığı ile ortaya konulamamıştır. Wang Prostat Spesifik Antijeni (PSA) keşfetmiştir. PSA önemli bir tümör belirtecidir ancak organa özgü olmasına karşın kansere özgü değildir. Vücutta meydana gelen enflamatuvar durumlarda enflamasyonun meydana geldiği yerdeki dokuda histopatolojik değişikliklerin ortaya çıktığı bilinmektedir. Enflamatuvar sürecin diğer bazı tümörlerde olduğu gibi, prostatik karsinogenezde de önemli bir yeri olduğunu düşündüren bilimsel veriler mevcuttur. Buna göre enfeksiyona bir cevap olarak dokuda reaktif oksijen ve nitrojen türleri oluşmakta ve oluşan bu ürünler hücrede DNA hasarına yol açmaktadırlar. Kronik enflamasyonun gerek doku hasarı gerek enflamatuvar süreçte ortaya çıkan mediatörler aracılığı ile kanser gelişiminde rol oynayabileceği gittikçe artan araştırmalar ile ortaya konulmaktadır. Sonuçta, enflamatuvar süreci tetikleyen, idame ettiren koşullar prostatik karsinogenez açısından çok önemli olabilirler.

Anahtar Kelimeler

• Kronik prostatit
• prostat kanseri
• enflamasyon
• doku hasarý

Kaynakça

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