Risperidone and nocturnal enuresis as a rare side effect

Öz

For children and adolescents, risperidone is proposed to be an effective agent for treating many psychiatric disorders such as psychotic disorders, pervasive developmental disorders, conduct disorder and behavioral problems accompanying mental retardation. Excessive appetite, weight gain, and sedation are among the most common adverse effects; on the other hand risperidone-induced enuresis is rarely reported. A case with risperidone-induced enuresis will be presented and the results will be discussed using a number of relevant case studies from the literature.

Anahtar Kelimeler

• Risperidone
• nocturnal enuresis
• side effect

Risperidon ve nadir bir yan etki olarak enürezis nokturna

Öz

Çocuk ve gençlerde risperidon psikotik bozukluk, yaygýn geliþimsel bozukluklar, davraným bozukluðu ve mental retardasyona eþlik eden davranýþ sorunlarý gibi birçok psikiyatrik bozukluðun tedavisinde etkin olabilecek bir ajan olarak belirtilmektedir. Ýþtah artýþý, kilo alýmý ve sedasyon sýk görülen yan etkiler olmasýna raðmen risperidona baðlý geliþen enürezis nadir görülen bir yan etkidir. Risperidona baðlý enürezis nokturna geliþen bir olgu sunulup bulgularýmýz literatür bilgileri eþliðinde tartýþýlmýþtýr.

Anahtar Kelimeler

• Risperidon
• enürezis nokturna
• yan etki

Kaynakça

1. Öztürk M, Sayar K, Tüzün Ü. Asperger bozukluðu olan çocuklarda risperidon kullanýmý: olgu sunumu. Klinik Psikofarmakoloji Bülteni 2000; 10(1): 51-55.
2. Took KJ, Buck BL. Enuresis with combined risperidone and SSRI use. J Am Acad Child Adolesc Psychiatry 1996; 35(7): 840-41.
3. Synder R, Turgay A, Aman M, Binder C, Fisman S, Carroll A. Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs. J Am Acad Child Adolesc Psychiatry 2002; 41(9): 1026-36.
4. Findling RL, Aman MG, Eerdekens M, Derivan A, Lyons B. Long term, open label study of risperidone in children with severe disruptive behaviors and below- average IQ. Am J Psychiatry 2004; 161(4): 677-84.
5. Hergüner S, Mukaddes NM. Risperidone induced enuresis in two children with autistic disorder. J Child Adolesc Psychopharmacol 2007; 17(4): 527-30.
6. Ghanizadeh A, Mohsen Kianpoor M. Cessation of risperidone-induced incontinency by valproate in a child with pervasive developmental disorder. Prim Psychiatry 2007; 15(4): 32- 4.
7. Poyurovsky M, Weizman A. Risperidone induced nocturnal enuresis. Isr J Psychiatry Relat Sci 1997; 34(3): 247-48.
8. Vokas CS, Steele VM, Norris JI, Vernon LT, Brescan DW. Incidence of risperidone induced incontinence. Schizophr Res 1997; 24(1): 267.

9. Kandil ST, Aksu HB, Ozyavuz R. Reversible nocturnal enuresis in children receiving SSRI with or without risperidone: presentation of five cases. Isr J of Psychiatry Relat Sci 2004; 41(3): 218-21.
10. Diagnostic and Statistical Manual of Mental Disorders- Fourth edition (DSM-IV). American Psychiatric Association. Washington, Amerikan Psychiatric Press, 1994.
11. Kantrowitz JT, Srihari VH, Tek C. Three cases of risperidone-induced enuresis. Schizophr Res 2006; 84(1): 174-75.
12. Steingard S. Use of desmopressin to treat clozapine- induced nocturnal enuresis. J Clin Psychiatry1994; 55(7): 315-16.
13. Fuller MA, Borovicka MC, Jaskiw GE, Simon MR, Kwon K, Konicki PE. Clozapine induced urinary incontinence: incidence and treatment with ephedrine. J Clin Psychiatry 1996; 57(11): 517-18.