Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler

Aylin Gökhan; Kubilay Doğan Kılıç; Kanat Gülle; Yiğit Uyanıkgil; Türker Çavuşoğlu

doi:10.17343/sdutfd.619417

Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler

Öz

Fizyolojik ve patolojik durumlarda, işleyişleri farklı, nekroz ve apoptoz olarak adlandırılan iki ana hücre ölümü meydana gelir. Apoptoz basamaklarındaki disregülasyonun kanser veya otoimmüniteyi tetiklediği bildirilmiş olup, aşırı apoptoz ise dejeneratif hastalıklarla ilişkilendirilmektedir. Proliferasyon artışıyla karakterize edilen kanserin tedavisi için hücrelerin apoptozdan kurtulma yolları araştırılmaktadır. Bununla ilişkili olarak kanser hücrelerinde Bcl-2, Bcl-xL ve Mcl-1 gibi antiapoptotik proteinlerin arttığı, proapoptotik proteinlerin ise azaldığı belirlenmiştir. Hücre ölümünde görev alan birçok protein ve protein kompleksleri arasında bir diğer önemli grubu apoptoz inhibitörü (IAP) protein ailesi oluşturmaktadır. IAP’lar apoptozda hem intrinsik hem de ekstrinsik yolağı baskılayabilen endojen kaspaz inhibitörleri olarak fonksiyon görmekte olup, apoptoz dışında hücre bölünmesi ve immün regülasyonda da rol almaktadırlar. Bcl-2 ve IAP ailesi üyeleri gibi aşırı ekspresyonu tespit edilen proteinler, hem tanı koyma hem de tedavi aşamasında yarar sağlamaktadır. Günümüzde sadece kanser hücresini hedefleyen ilaçlar tedavi protokolleri arasına girmiş bulunmaktadır. Bu derlemede apoptotik yolaklara ait moleküler mekanizmalar ve onlarla ilişkili hedefe yönelik yeni tedavi yaklaşımları genel hatlarıyla irdelenmektedir.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Derleme

Yazarlar

Aylin Gökhan
0000-0002-6254-157X
Türkiye

Kubilay Doğan Kılıç
0000-0002-9484-0777
Türkiye

Kanat Gülle Bu kişi benim
0000-0002-6337-8962
Türkiye

Yiğit Uyanıkgil
0000-0002-4016-0522
Türkiye

Türker Çavuşoğlu ^* Bu kişi benim
Türkiye

Yayımlanma Tarihi

25 Aralık 2020

Gönderilme Tarihi

12 Eylül 2019

Kabul Tarihi

25 Aralık 2019

Yayımlandığı Sayı

Yıl 2020 Cilt: 27 Sayı: 4

DOI

https://doi.org/10.17343/sdutfd.619417

IZ

https://izlik.org/JA52KS75LC

Kaynak Göster

RIS / Bibtex

APA

Gökhan, A., Kılıç, K. D., Gülle, K., Uyanıkgil, Y., & Çavuşoğlu, T. (2020). Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler. Medical Journal of Süleyman Demirel University, 27(4), 565-573. https://doi.org/10.17343/sdutfd.619417

AMA

1.Gökhan A, Kılıç KD, Gülle K, Uyanıkgil Y, Çavuşoğlu T. Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler. SDÜ Tıp Fak Derg. 2020;27(4):565-573. doi:10.17343/sdutfd.619417

Chicago

Gökhan, Aylin, Kubilay Doğan Kılıç, Kanat Gülle, Yiğit Uyanıkgil, ve Türker Çavuşoğlu. 2020. “Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler”. Medical Journal of Süleyman Demirel University 27 (4): 565-73. https://doi.org/10.17343/sdutfd.619417.

EndNote

Gökhan A, Kılıç KD, Gülle K, Uyanıkgil Y, Çavuşoğlu T (01 Aralık 2020) Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler. Medical Journal of Süleyman Demirel University 27 4 565–573.

IEEE

[1]A. Gökhan, K. D. Kılıç, K. Gülle, Y. Uyanıkgil, ve T. Çavuşoğlu, “Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler”, SDÜ Tıp Fak Derg, c. 27, sy 4, ss. 565–573, Ara. 2020, doi: 10.17343/sdutfd.619417.

ISNAD

Gökhan, Aylin - Kılıç, Kubilay Doğan - Gülle, Kanat - Uyanıkgil, Yiğit - Çavuşoğlu, Türker. “Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler”. Medical Journal of Süleyman Demirel University 27/4 (01 Aralık 2020): 565-573. https://doi.org/10.17343/sdutfd.619417.

JAMA

1.Gökhan A, Kılıç KD, Gülle K, Uyanıkgil Y, Çavuşoğlu T. Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler. SDÜ Tıp Fak Derg. 2020;27:565–573.

MLA

Gökhan, Aylin, vd. “Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler”. Medical Journal of Süleyman Demirel University, c. 27, sy 4, Aralık 2020, ss. 565-73, doi:10.17343/sdutfd.619417.

Vancouver

1.Aylin Gökhan, Kubilay Doğan Kılıç, Kanat Gülle, Yiğit Uyanıkgil, Türker Çavuşoğlu. Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler. SDÜ Tıp Fak Derg. 01 Aralık 2020;27(4):565-73. doi:10.17343/sdutfd.619417

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Food Science & Nutrition

https://doi.org/10.1002/fsn3.70528