ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Sibel Akar; Emel Öykü Çetin Uyanıkgil

doi:10.17343/sdutfd.641016

ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Öz

Günümüzde yara iyileşmesi üzerine yapılan bir çok çalışma bulunmaktadır. Yara iyileşmesinde etkili olduğu kanıtlanan birçok etkin madde ve farmasötik dozaj şekli tanımlanmıştır. Antimikrobiyal peptitler (AMP) insanların, hayvanların ve bitkilerin bir çok doku ve organları tarafından üretilen peptitlerdir ve doğal immün sistemin yadsınamaz savaşçılarıdır. AMP’ler; antibakteriyel, antiviral, antifungal, antiparazitik, insektisidal, kemotaktik, yara iyileşmesi ve büyüme uyarıcı olarak pek çok etkiye sahip olabilmektedirler. AMP’lerin, proinflamatuar yanıttaki potansiyelleri üzerine yapılan pek çok çalışma bulunmaktadır. AMP’ler yara iyileşmesinde rol almalarının yanı sıra bir çok insan dermal hastalığında da önemli bir potansiyel taşımaktadırlar. Bu yazıda proinflamatuar yanıtın bir parçası olan yara iyileşme sürecinde gerçekleşen birbiri ile bağlantılı basamaklar açıklanmış ve bu basamaklarda AMP‘lerin aldıkları roller ve önemlerinden bahsedilmiştir; ayrıca insan dermal hastalıklarındaki potansiyellerinin araştırıldığı çalışmalara da değinilmiştir.

Anahtar Kelimeler

antimikrobiyal peptit,yara,proinflamatuar,LL-37,hBD-3

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Eczacılık ve İlaç Bilimleri

Bölüm

Derleme

Yazarlar

Sibel Akar Bu kişi benim
Türkiye

Emel Öykü Çetin Uyanıkgil ^*
0000-0001-8822-9130
Türkiye

Yayımlanma Tarihi

1 Mart 2020

Gönderilme Tarihi

31 Ekim 2019

Kabul Tarihi

20 Aralık 2019

Yayımlandığı Sayı

Yıl 2020 Cilt: 27 Sayı: 1

DOI

https://doi.org/10.17343/sdutfd.641016

IZ

https://izlik.org/JA68RE64BU

Kaynak Göster

RIS / Bibtex

APA

Akar, S., & Çetin Uyanıkgil, E. Ö. (2020). ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Medical Journal of Süleyman Demirel University, 27(1), 145-153. https://doi.org/10.17343/sdutfd.641016

AMA

1.Akar S, Çetin Uyanıkgil EÖ. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fak Derg. 2020;27(1):145-153. doi:10.17343/sdutfd.641016

Chicago

Akar, Sibel, ve Emel Öykü Çetin Uyanıkgil. 2020. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University 27 (1): 145-53. https://doi.org/10.17343/sdutfd.641016.

EndNote

Akar S, Çetin Uyanıkgil EÖ (01 Mart 2020) ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Medical Journal of Süleyman Demirel University 27 1 145–153.

IEEE

[1]S. Akar ve E. Ö. Çetin Uyanıkgil, “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”, SDÜ Tıp Fak Derg, c. 27, sy 1, ss. 145–153, Mar. 2020, doi: 10.17343/sdutfd.641016.

ISNAD

Akar, Sibel - Çetin Uyanıkgil, Emel Öykü. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University 27/1 (01 Mart 2020): 145-153. https://doi.org/10.17343/sdutfd.641016.

JAMA

1.Akar S, Çetin Uyanıkgil EÖ. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fak Derg. 2020;27:145–153.

MLA

Akar, Sibel, ve Emel Öykü Çetin Uyanıkgil. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University, c. 27, sy 1, Mart 2020, ss. 145-53, doi:10.17343/sdutfd.641016.

Vancouver

1.Sibel Akar, Emel Öykü Çetin Uyanıkgil. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fak Derg. 01 Mart 2020;27(1):145-53. doi:10.17343/sdutfd.641016