ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Sibel Akar; Emel Öykü Çetin Uyanıkgil

doi:10.17343/sdutfd.641016

ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Abstract

Günümüzde yara iyileşmesi üzerine yapılan bir çok çalışma bulunmaktadır. Yara iyileşmesinde etkili olduğu kanıtlanan birçok etkin madde ve farmasötik dozaj şekli tanımlanmıştır. Antimikrobiyal peptitler (AMP) insanların, hayvanların ve bitkilerin bir çok doku ve organları tarafından üretilen peptitlerdir ve doğal immün sistemin yadsınamaz savaşçılarıdır. AMP’ler; antibakteriyel, antiviral, antifungal, antiparazitik, insektisidal, kemotaktik, yara iyileşmesi ve büyüme uyarıcı olarak pek çok etkiye sahip olabilmektedirler. AMP’lerin, proinflamatuar yanıttaki potansiyelleri üzerine yapılan pek çok çalışma bulunmaktadır. AMP’ler yara iyileşmesinde rol almalarının yanı sıra bir çok insan dermal hastalığında da önemli bir potansiyel taşımaktadırlar. Bu yazıda proinflamatuar yanıtın bir parçası olan yara iyileşme sürecinde gerçekleşen birbiri ile bağlantılı basamaklar açıklanmış ve bu basamaklarda AMP‘lerin aldıkları roller ve önemlerinden bahsedilmiştir; ayrıca insan dermal hastalıklarındaki potansiyellerinin araştırıldığı çalışmalara da değinilmiştir.

Keywords

antimikrobiyal peptit,yara,proinflamatuar,LL-37,hBD-3

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Details

Primary Language

Turkish

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Review

Authors

Sibel Akar This is me
Türkiye

Emel Öykü Çetin Uyanıkgil ^*
0000-0001-8822-9130
Türkiye

Publication Date

March 1, 2020

Submission Date

October 31, 2019

Acceptance Date

December 20, 2019

Published in Issue

Year 2020 Volume: 27 Number: 1

DOI

https://doi.org/10.17343/sdutfd.641016

IZ

https://izlik.org/JA68RE64BU

Cite

RIS / Bibtex

APA

Akar, S., & Çetin Uyanıkgil, E. Ö. (2020). ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Medical Journal of Süleyman Demirel University, 27(1), 145-153. https://doi.org/10.17343/sdutfd.641016

AMA

1.Akar S, Çetin Uyanıkgil EÖ. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Med J SDU. 2020;27(1):145-153. doi:10.17343/sdutfd.641016

Chicago

Akar, Sibel, and Emel Öykü Çetin Uyanıkgil. 2020. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University 27 (1): 145-53. https://doi.org/10.17343/sdutfd.641016.

EndNote

Akar S, Çetin Uyanıkgil EÖ (March 1, 2020) ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Medical Journal of Süleyman Demirel University 27 1 145–153.

IEEE

[1]S. Akar and E. Ö. Çetin Uyanıkgil, “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”, Med J SDU, vol. 27, no. 1, pp. 145–153, Mar. 2020, doi: 10.17343/sdutfd.641016.

ISNAD

Akar, Sibel - Çetin Uyanıkgil, Emel Öykü. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University 27/1 (March 1, 2020): 145-153. https://doi.org/10.17343/sdutfd.641016.

JAMA

1.Akar S, Çetin Uyanıkgil EÖ. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Med J SDU. 2020;27:145–153.

MLA

Akar, Sibel, and Emel Öykü Çetin Uyanıkgil. “ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ”. Medical Journal of Süleyman Demirel University, vol. 27, no. 1, Mar. 2020, pp. 145-53, doi:10.17343/sdutfd.641016.

Vancouver

1.Sibel Akar, Emel Öykü Çetin Uyanıkgil. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. Med J SDU. 2020 Mar. 1;27(1):145-53. doi:10.17343/sdutfd.641016