İLK TRİMESTER GEBELİKLERİNDE SUBKLİNİK VE AŞİKAR HİPOTİROİDİ İNSİDANSI

Year 2022, , 1 - 6, 01.03.2022

Aylin Sağlam

https://doi.org/10.17343/sdutfd.887567

Abstract

Amaç
Bu çalışma Aksaray ilindeki ilk trimester gebeliklerinde
subklinik ve aşikar hipotiroidi sıklığının belirlenmesi
amacıyla planlanmıştır.
Gereç ve Yöntem
Bu bir retrospektif çalışma olup kadın hastalıkları
ve doğum polikliniğine gebeliğin 7-12inci haftasında
başvuran ve geçmişinde hipotirodi tanısı ve/veya tiroit
hormon replasman tedavisi öyküsü bulunmayan
tekil 502 gebenin yaş, serum tiroit-stimülan hormon,
serbest tri-iyodotronin ve serbest tiroksin düzeyleri
hastane kayıt sisteminden elde edildi. Serum TSH için
üst sınır 4 mIU/L olarak kabul edildi. Karşılaştırmalarda
Mann Whitney U ile ki-kare testleri kullanıldı ve p
<0.05 istatistiksel olarak alındı.
Bulgular
Olguların yaş ortalaması 26.3 ± 5.9 yıl idi. Subklinik
ve aşikar hipotiroidi sıklığı sırasıyla %4 ve %0 olarak
bulundu. Tiroit fonksiyon test sonuçları normal olan
ve subklinik hipotiroidisi olan gebelerin yaşları benzer
olarak saptandı (p=0.201).
Sonuç
Gebelik öncesinde hipotiroidi tanısı olmayan asemptomatik
gebelerin ilk trimesterde hipotiroidi açısından
taranması, anne yaşından bağımsız olarak aşikar
hastalık tanısında kısıtlı role sahip gözükmektedir.
Toplum tabanlı trimestere özgül TSH normal referans
değerlerinin belirlenmesi, gerçek subklinik hipotiroidi
insidansının saptanması bakımından önem taşıyabilir.

Keywords

Aşikar hipotiroidi, Gebelik, Subklinik hipotiroidi, Tiroit stimülan hormon

Project Number

2020/30

THE INCIDENCE OF SUBCLINICAL AND OVERT HYPOTHYROIDISM IN FIRST TRIMESTER PREGNANCIES

Abstract

Objective
This study aims to define the first-trimester prevalence
of overt and subclinical hypothyroidism in Aksaray
province.
Material and Methods
This is a retrospective study carried out in a single
obstetrics and gynecology outpatient unit, including
hospital-based data on maternal age, serum thyroidstimulating
hormone, thyroxine, and tri-iodothyronine
levels from 502 singleton pregnancies at 7-12 weeks
of gestational age. Cut-off for serum TSH was
considered as 4 mIU/L. Mann-Whitney U and chisquare
tests were used for comparisons, with p <0.05
considered statistically significant.
Results
The mean maternal age was 26.3 ± 5.9 years.
Subclinical and overt hypothyroidism was present in
4% and 0% of included women, respectively. Mean
maternal age in euthyroid and subclinical hypothyroid
pregnancies were similar (p=0.201).
Conclusions
First trimester screening of asymptomatic women
without a prepregnancy diagnosis of hypothyroidism
seems to be limited for diagnosing overt hypothyroidism
during pregnancy, regardless of maternal age.
Definition of population-based trimester specific
reference ranges for serum TSH may be important
to detect the genuine prevalence of subclinical
hypothyroidism

Keywords

Overt hypothyroidism, Pregnancy, Subclinical hypothyroidism, Thyroid-stimulating hormone

Project Number

2020/30

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