COVID-19: Antiviral Therapy

Öz

The cases reported in Wuhan province in China in December 2020 spread all over the world within a few months, and the SARS-CoV-2 infection pandemic was declared by the World Health Organization (WHO) on March 11, 2020. Since the first cases were seen, some drugs used in clinical practice have been repurposed and started to be used in the treatment of COVID-19. Many articles on the subject have been published without peer review, and a serious information pollution has emerged. As of the date the pandemic was declared in the world, the first patient with coronavirus infection was reported in our country. Repurposed agents like hydroxychloroquine, favipiravir and remdesivir have been used in treatment for antiviral effects in accordance with the Ministry of Health's Coronavirus Guideline and international literature in our country. Recently, monoclonal antibodies have started to take place in clinical practice. In this article, the drugs used in the antiviral treatment of SARS-CoV-2 infection during the pandemic process are reviewed.

Anahtar Kelimeler

• covid
• therapy
• antiviral

COVID-19: Antiviral Tedavi

Öz

Aralık 2020’de Çin’de Wuhan eyaletinde bildirilen vakalar birkaç ay içinde tüm dünyaya yayılmış ve 11 Mart 2020’de Dünya Sağlık Örgütü (DSÖ) tarafından SARS-CoV-2 enfeksiyonu pandemisi ilan edilmiştir. İlk vakaların görülmeye başlanmasından itibaren klinik pratikte kullanılan bazı ilaçlar yeniden konumlandırılarak COVID-19 tedavisinde kullanılmaya başlanmıştır. Konuyla ilgili çok sayıda makale hakem değerlendirmesi olmadan yayınlanmış, ciddi bir bilgi kirliliği ortaya çıkmıştır. Dünyada pandemi ilan edildiği tarih itibariyle ülkemizde de ilk koronavirüs enfeksiyonu olan hasta bildirilmiştir. Ülkemizde Sağlık Bakanlığı Koronavirüs Rehberi doğrultusunda yeniden konumlandırılan ajanlar antiviral etki amacıyla tedavide kullanılmıştır. Hidroksiklorokin, favipiravir ve remdesivir kullanılan antiviral ajanlardır. Son zamanlarda monoklonal antikorlar klinik pratikte yer almaya başlamıştır. Bu yazıda SARS-CoV-2 enfeksiyonunun antiviral tedavisinde pandemi sürecinde kullanılan ilaçlar gözden geçirilmiştir.

Anahtar Kelimeler

• covid
• tedavi
• antiviral

Kaynakça

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