Vitamin C and Vitamin D in COVID-19 Therapy

Öz

Coronavirus disease 2019 (COVID-19) is a disease that can lead to a broad spectrum clinical picture, from asymptomatic course caused by SARS-CoV-2 virus, accompanied by respiratory failure and may result in death. The number of proven therapeutic options for the prevention and treatment of COVID-19 is limited. Vitamin and mineral deficiencies during viral infections are associated with adverse clinical outcomes. Clinical studies are indicating that vitamin supplementation can reduce the incidence and severity of acute respiratory infections. With the COVID-19 pandemic, researches on the benefits of vitamins in disease prevention and treatment have increased. Although some studies report that vitamins are effective, it is observed that there are studies that do not support this statement. Vitamin D plays an important role in enhancing the physical barrier against viruses, stimulating the production of antimicrobial peptides, and preventing cytokine storms by reducing inflammatory cytokine production. It is stated that vitamin C application can increase survival rates by contributing to enhancing the imune response in COVID-19 patients. The purpose of this review is to evaluate the role of vitamin C and vitamin D in COVID-19.

Anahtar Kelimeler

• Vitamin D
• Vitamin C
• Covid 19

COVID-19 Tedavisinde Vitamin C ve D

Öz

Coronavirüs hastalığı 2019 (COVID-19) SARS-CoV-2 virüsünün neden olduğu asemptomatik seyirden, solunum yetmezliğinin eşlik ettiği ve ölümle sonuçlanabilen geniş spektrumda klinik tabloya yol açan hastalıktır. Korunma ve tedavisinde etkinliği kanıtlanmış seçenek sayısı sınırlıdır. Viral enfeksiyonlar sırasında vitamin ve mineral eksiklikleri olumsuz klinik sonuçlarla ilişkilendirilmektedir. Vitamin takviyesinin akut solunum yolu enfeksiyonu insidansını ve şiddetini azaltabileceğini belirten klinik çalışmalar mevcuttur. COVID-19 pandemisiyle birlikte vitaminlerin hastalıktan korunma ve tedavideki yararlarıyla ilgili araştırmalar artmış olup etkin olduğunu bildiren yayınlar kadar, bu sonucu desteklemeyen çalışmaların da olduğu gözlenmektedir. D vitamininin virüslere karşı fiziksel bariyerin güçlendirilmesinde, antimikrobiyal peptitlerin üretiminin uyarılmasında ve inflamatuvar sitokin üretiminin azalmasını sağlayarak sitokin fırtınalarının önlenmesinde önemli rolü olduğu belirtilmektedir. Vitamin C uygulamasının COVID-19 hastalarında immün yanıtın güçlendirilmesine katkıda bulunarak sağ kalım oranlarını arttırabileceği ifade edilmektedir. Bu derlemenin amacı COVID-19 hastalığında C ve D vitaminlerinin yararının değerlendirilmesidir.

Anahtar Kelimeler

• Vitamin C
• Vitamin D
• COVID 19

Kaynakça

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