Plateletten zengin fibrinin iyileşme ve rejenerasyon sürecindeki rolü ve ortopedik cerrahide kullanımına dair bir derleme

Yıl 2019, Cilt: 26 Sayı: 3, 354 - 361, 01.09.2019

Turan Cihan Dülgeroğlu Baran Şen

https://doi.org/10.17343/sdutfd.451366

Cited By: 1

Öz

Platelet-rich fibrin (PRF) is a naturally derived fibrin
scaffold and second-generation platelet concentrate with great potential for
promoting wound healing and the regenerative process via the secretion of
different cytokines and growth factors, enhanced osteoblast adhesion, and
augmentation of collagen protein expression. Given the significance of the
scope of PRF in the field of orthopedic surgery, this study presents an overview
for the role of PRF in the recovery and the regenerative process with emphasis
on its rationale for use and outcome in orthopedic surgery. In conclusion, PRF
offers a new dimension for clinical research with expanded range of potential
applications in orthopedic surgery with a simpler preparation protocol, a
stronger and more stable fibrin polymerization leading to a physiologic
architecture, occurrence of natural clot formation allowing formation of a
flexible and fine fibrin network and a continual and steady release of
cytokines and growth factors, mimicking the requirements of the reparative
tissue and wound healing processes. 

Anahtar Kelimeler

Platelet rich fibrin; wound healing; tissue regeneration; growth factors; orthopedic surgery

A review of the role of platelet rich fibrin in healing and regenerative process and its use in orthopaedic surgery

Öz

Kaynakça

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