Dietary Antioxidant Supplements and Exercise

Öz

Nutritional supplements are commonly used among by athletes. Many athletes think that antioxidant supplements decrease muscle damage, immunodeficiency and fatigue and thus cause performance gain.

When the literature is examined, it appears that the majority of investigations focus that effects of antioxidant supplements on markers and muscle damage induced oxidative stress rather than exercise performance. In addition, in some studies it is stated that antioxidant supplements are a positive effect on muscle fatigue after unaccustomed exercise. However, the relationship between antioxidant supplements and exercise is not clear, despite increased researches. This review will attempt to explain the relationship between dietary antioxidant supplements and exercise in the light of various investigations.

Anahtar Kelimeler

• Antioxidant,Exercise,Performance

Diyetle Alınan Antioksidan Maddeleri ve Egzersiz

Öz

Besin takviyeleri sporcular arasında yaygın şekilde kullanılmaktadır. Birçok sporcu antioksidan takviyelerinin kas hasarını, immun bozukluğu ve yorgunluğu azalttığını ve böylece performans artışına neden olduğunu düşünmektedir. 

Literatür incelendiğinde, araştırmaların çoğunun antioksidan takviyelerin egzersiz performansı üzerine etkilerinden ziyade oksidatif stresin neden olduğu belirteçlere ve kas hasarına olan etkisine odaklandığı görülmektedir. Ayrıca bazı çalışmalarda antioksidan takviyelerin alışık olunmayan egzersiz sonrası oluşan kas yorgunluğu üzerine pozitif etkisi olduğunu belirtilmektedir. Ancak artan araştırmalara rağmen antioksidan takviyeleri ve egzersiz arasındaki ilişki net değildir. Bu derleme, diyetle alınan antioksidan takviyelerini ve egzersiz arasındaki ilişkiyi çeşitli araştırmalar ışığında açıklamaya çalışacaktır.

Anahtar Kelimeler

• antioksidan,egzersiz,performans

Kaynakça

1. Alessio HM 1993. Exercise-induced oxidative stress. Med Sci Sports Exerc. 25, 218-24.
2. Avery NG, Kaiser JL, Sharman MJ, Scheett TP, Barnes DM, Gómez AL, Kraemer WJ, Volek JS, 2003. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. J Strength Cond Res. 17, 801-809.
3. Azqueta A, Collins A, 2016. Polyphenols and DNA Damage: A Mixed Blessing. Nutrients. 3, 8-12. Bloomer RJ, Falvo MJ, Schilling BK, Smith WA, 2007. Prior exercise and antioxidant supplementation: effect on oxidative stress and muscle injury. J Int Soc Sports Nutr. 3, 4-9.
4. Borgström L, Kagedal B, Paulsen O, 1986. Pharmokinetics of N-acetylcystein in man. Eur J Clin Pharmacol. 31, 217-222.
5. Bowtell JL, Sumners DP, Dyer A, Fox P, Mileva KN, 2011. Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med Sci Sports Exerc. 43, 1544-1551.
6. Bravo L, 1998. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev.56, 317-333. Buratti P, Gammella E, Rybinska I, Cairo G, Recalcati S, 2015. Recent Advances in Iron Metabolism: Relevance for Health, Exercise, and Performance. Med Sci Sports Exerc. 47,1596-604.
7. Cairo G, Bernuzzi F, Recalcati S, 2006. A precious metal: Iron, an essential nutrient for all cells. Genes Nutr. 1, 25-39.
8. Capó X, Martorell M, Sureda A, Riera J, Drobnic F, Tur JA, Pons A, 2016. Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age. Nutrients.9, 8-10.

9. Chang WH, Hu SP, Huang YF, Yeh TS, Liu JF, 2010. Effect of purple sweet potato leaves consumption on exercise-induced oxidative stress and IL-6 and HSP72 levels. J Appl Physiol. 109, 1710-15.
10. Chen CY, Lapsley K, Blumberg J, 2006. A nutrition and health perspective on almonds. J Sci Food Agric. 86, 2245-2250.
11. Chu A, Petocz P, Samman S, 2016. Immediate Effects of Aerobic Exercise on Plasma/Serum Zinc Levels: A Meta-analysis. Med Sci Sports Exerc. 48, 726-33.
12. Cobley JN, Marrin K, 2012. Vitamin E supplementation does not alter physiological performance at fixed blood lactate concentrations in trained runners. J Sports Med Phys Fitness. 52, 63-70.
13. Cobley JN, McGlory C, Morton JP, Close GL, 2011. N-Acetylcysteine's attenuation of fatigue after repeated bouts of intermittent exercise: practical implications for tournament situations. Int J Sport Nutr Exerc Metab. 21, 451-61.
14. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB, 2004. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 52, 1098-104.
15. Connolly DA, McHugh MP, Padilla-Zakour OI, Carlson L, Sayers SP, 2006. Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. Br J Sports Med. 40, 679-83.
16. Cureton KJ, Tomporowski PD, Singhal A, Pasley JD, Bigelman KA, Lambourne K, Trilk JL, McCully KK, Arnaud MJ, Zhao Q, 2009. Dietary quercetin supplementation is not ergogenic in untrained men. J Appl Physiol. 107, 1095-104.
17. Dartsch PC, 2008. Antioxidant potential of selected Spirulina platensis preparations. Phytother Res. 22, 627-633.
18. Davis JM, Carlstedt CJ, Chen S, Carmichael MD, Murphy EA, 2010. The dietary flavonoid quercetin increases VO(2max) and endurance capacity. Int J Sport Nutr Exerc Metab. 20, 1-3.
19. DellaValle DM, 2013. Iron supplementation for female athletes: effects on iron status and performance outcomes. Curr Sports Med Rep. 12, 234-9.
20. DellaValle DM, Haas JD, 2014. Iron supplementation improves energetic efficiency in iron-depleted female rowers. Med Sci Sports Exerc. 46, 1204-15.
21. Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV, 2017. Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients. 6, 1-9.
22. Durazzo A, Zaccaria M, Polito A, Maiani G, Carcea M, 2013. Lignan Content in Cereals, Buckwheat and Derived Foods. Foods. 2, 53-63.
23. Dwenger A, Funck M, Lueken B, Schweitzer G, Lehmann U, 1992. Effect of ascorbic acid on neutrophil functions and hypoxanthine/xanthine oxidase-generated, oxygen-derived radicals. Eur J Clin Chem Clin Biochem. 30, 184-91.
24. Finaud J, Lac G, Filaire E, 2006. Oxidative stress : relationship with exercise and training. Sports Med. 36, 327-58. Ganio MS, Armstrong LE, Johnson EC, Klau JF, Ballard KD, Michniak-Kohn B, Kaushik D, Maresh CM, 2010. Effect of quercetin supplementation on maximal oxygen uptake in men and women. J Sports Sci. 28, 201-8.
25. Gliemann L, Schmidt JF, Olesen J, Biensø RS, Peronard SL, Grandjean SU, Mortensen SP, Nyberg M, Bangsbo J, Pilegaard H, Hellsten Y, 2013. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 591, 5047-59.
26. Goldfarb AH, 1993. Antioxidants: role of supplementation to prevent exercise-induced oxidative stress. Med Sci Sports Exerc. 25, 232-6.
27. Goldfarb AH, Garten RS, Cho C, Chee PD, Chambers LA, 2011. Effects of a fruit/berry/vegetable supplement on muscle function and oxidative stress. Med Sci Sports Exerc. 43, 501-8.
28. Holdiness MR, 1991. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet. 20, 123-34.
29. Hurst RD, Wells RW, Hurst SM, McGhie TK, Cooney JM, Jensen DJ, 2010. Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro. Mol Nutr Food Res. 54, 353-63.
30. Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, Ahmad AS, Islam F,2006. Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res. 171, 9-16.
31. Jówko E, Długołęcka B, Makaruk B, Cieśliński I, 2015. The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. Eur J Nutr.54, 183-91.
32. Jówko E, Sacharuk J, Balasińska B, Ostaszewski P, Charmas M, Charmas R, 2011. Green tea extract supplementation gives protection against exercise-induced oxidative damage in healthy men. Nutr Res. 31, 813-21.
33. Kalafati M, Jamurtas AZ, Nikolaidis MG, Paschalis V, Theodorou AA, Sakellariou GK, Koutedakis Y, Kouretas D, 2010. Ergogenic and antioxidant effects of spirulina supplementation in humans. Med Sci Sports Exerc. 42, 142-51.
34. Kang SW, Hahn S, Kim JK, Yang SM, Park BJ, Chul Lee S, 2012. Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial. J Clin Biochem Nutr. 50, 106-13.
35. Knez WL, Peake JM, 2010. The prevalence of vitamin supplementation in ultraendurance triathletes. Int J Sport Nutr Exerc Metab. 20, 507-14.
36. Kressler J, Millard-Stafford M, Warren GL, 2011. Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Med Sci Sports Exerc. 43, 2396-404.
37. Kojo S, 2004. Vitamin C: basic metabolism and its function as an index of oxidative stress. Curr Med Chem. 11, 1041-64.
38. Lafay S, Jan C, Nardon K, Lemaire B, Ibarra A, Roller M, Houvenaeghel M, Juhel C, Cara L, 2009. Grape extract improves antioxidant status and physical performance in elite male athletes. J Sports Sci Med. 8, 468-80.
39. Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN, 2006. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol. 98, 220-6.
40. Lukaski HC, 2004. Vitamin and mineral status: effects on physical performance. Nutrition. 20, 632-44.
41. Lukaski HC, 2005. Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr. 81, 1045-51.
42. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L, 2004. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 79, 727-47.
43. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C, 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 81, 230-42.
44. Matias CN, Santos DA, Monteiro CP, Silva AM, Raposo Mde F, Martins F, Sardinha LB, Bicho M, Laires MJ, 2010. Magnesium and strength in elite judo athletes according to intracellular water changes. Magnes Res. 23, 138-41.
45. Matuszczak Y, Farid M, Jones J, Lansdowne S, Smith MA, Taylor AA, Reid MB, 2005. Effects of N-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 32, 633-38.
46. McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, Jin F, Henson DA, 2011. Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling. Int J Sport Nutr Exerc Metab. 21, 328-37.
47. McGinley C, Shafat A, Donnelly AE, 2009. Does antioxidant vitamin supplementation protect against muscle damage? Sports Med. 39, 1011-32.
48. McKenna MJ, Medved I, Goodman CA, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X, 2006. N-acetylcysteine attenuates the decline in muscle Na+,K+-pump activity and delays fatigue during prolonged exercise in humans. J Physiol. 576, 279-88.
49. MacRae HS, Mefferd KM, 2006. Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int J Sport Nutr Exerc Metab. 16, 405-19.
50. Medved I, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X, McKenna MJ, 2004. N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals. J Appl Physiol. 97, 1477-85.
51. Morillas-Ruiz JM, Villegas García JA, López FJ, Vidal-Guevara ML, Zafrilla P, 2006. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr. 25, 444-453.
52. Murphy M, Eliot K, Heuertz RM, Weiss E, 2012. Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet. 112, 548-52.
53. Myburgh KH, 2014. Polyphenol supplementation: benefits for exercise performance or oxidative stress? Sports Med. 44, 57-70.
54. Newhouse IJ, Finstad EW, 2000. The effects of magnesium supplementation on exercise performance. Clin J Sport Med. 10, 195-200.
55. Nieman DC, Williams AS, Shanely RA, Jin F, McAnulty SR, Triplett NT, Austin MD, Henson DA, 2010. Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Med Sci Sports Exerc. 42, 338-45.
56. Ota N, Soga S, Shimotoyodome A, 2016. Daily consumption of tea catechins improves aerobic capacity in healthy male adults: a randomized double-blind, placebo-controlled, crossover trial. Biosci Biotechnol Biochem. 80, 2412-17.
57. Pinna M, Roberto S, Milia R, Marongiu E, Olla S, Loi A, Migliaccio GM, Padulo J, Orlandi C, Tocco F, Concu A, Crisafulli A, 2014. Effect of beetroot juice supplementation on aerobic response during swimming. Nutrients. 6, 605-15.
58. Polat Y, 2011. Effects of zinc supplementation on hematological parameters of high performance athletes. Afr J Pharm Pharmacol. 5, 1436-40.
59. Powers SK, Jackson MJ, 2008. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 88, 1243-76.
60. Reinke S, Taylor WR, Duda GN, von Haehling S, Reinke P, Volk HD, Anker SD, Doehner W, 2012. Absolute and functional iron deficiency in professional athletes during training and recovery. Int J Cardiol. 156, 186-91.
61. Richardson RS, Donato AJ, Uberoi A, Wray DW, Lawrenson L, Nishiyama S, Bailey DM, 2007. Exercise-induced brachial artery vasodilation: role of free radicals. Am J Physiol Heart Circ Physiol. 292, 1516-22.
62. Romero-Pérez AI, Ibern-Gómez M, Lamuela-Raventós RM, de La Torre-Boronat MC, 1999. Piceid, the major resveratrol derivative in grape juices. J Agric Food Chem. 47, 1533-6.
63. Sakellariou GK, Jackson MJ, Vasilaki A, 2014. Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases. Free Radic Res. 48, 12-29.
64. Samman S, 2007. Zinc. Nutr Diet. 64, 131-134.
65. Sandhu J.S, Bhardwaj D, Shenoy S, 2010. Efficacy of Spirulina Supplementation on Isometric Strength and Isometric Endurance of Quadriceps in Trained and Untrained Individuals – a comparative study. İbnosina J Med Bio Sci. 2, 79-86.
66. Santos DA, Matias CN, Monteiro CP, Silva AM, Rocha PM, Minderico CS, Bettencourt Sardinha L, Laires MJ, 2011. Magnesium intake is associated withstrength performance in elite basketball, handball and volleyball players. Magnes Res. 24, 215-19.
67. Santos SA, Silva ET, Caris AV, Lira FS, Tufik S, Dos Santos RV, 2016. Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia. J Hum Nutr Diet. 29, 516-22.
68. Setaro L, Santos-Silva PR, Nakano EY, Sales CH, Nunes N, Greve JM, Colli C, 2014. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci. 32, 438-45.
69. Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M, 2015. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 9, 1-13.
70. Silva LA, Pinho CA, Silveira PC, Tuon T, De Souza CT, Dal-Pizzol F, Pinho RA, 2010. Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction. J Physiol Sci. 60, 51-7.
71. Sousa M, Teixeira VH, Soares J, 2014. Dietary strategies to recover from exercise-induced muscle damage. Int J Food Sci Nutr. 65, 151-63.
72. Teixeira VH, Valente HF, Casal SI, Marques AF, Moreira PA, 2009. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc. 41, 1752-60.
73. Tennant DR, Davidson J, Day AJ, 2014. Phytonutrient intakes in relation to European fruit and vegetable consumption patterns observed in different food surveys. Br J Nutr. 112, 1214-25.
74. Trombold JR, Reinfeld AS, Casler JR, Coyle EF, 2011. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J Strength Cond Res. 25, 1782-8.
75. Urso ML, Clarkson PM, 2003. Oxidative stress, exercise, and antioxidant supplementation. Toxicology. 189, 41-54. Veronese N, Berton L, Carraro S, Bolzetta F, De Rui M, Perissinotto E, Toffanello ED, Bano G, Pizzato S, Miotto F, Coin A, Manzato E, Sergi G, 2014. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 100, 974-81.
76. Wilkerson DP, Hayward GM, Bailey SJ, Vanhatalo A, Blackwell JR, Jones AM, 2012. Influence of acute dietary nitrate supplementation on 50 mile time trial performance in well-trained cyclists. Eur J Appl Physiol. 112, 4127-34.
77. Wootton-Beard PC, Moran A, Ryan L, 2011. Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP, DPPH, ABTS and Folin–Ciocalteu methods. Food Res Int. 44, 217-224.
78. Yi M, Fu J, Zhou L, Gao H, Fan C, Shao J, Xu B, Wang Q, Li J, Huang G, Lapsley K, Blumberg JB, Chen CY, 2014. The effect of almond consumption on elements of endurance exercise performance in trained athletes. J Int Soc Sports Nutr. 11,11-18.
79. Zaveri NT, 2006. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 78, 2073-80.
80. Zimmermann MB, 2003. Vitamin and mineral supplementation and exercise performance. Sportmed Sporttrav. 5, 53-57.