Diş Hekimliği Öğrencilerinin İlaca Bağlı Olarak Çene Kemiklerinde Görülen Osteonekroz (MRONJ) ile İlgili Bilgi Düzeylerinin Değerlendirilmesi

Abstract

Amaç: Başta kemik metastazı olan kanser hastalarının tedavisi olmak üzere osteoporoz, Paget hastalığı, multiple myelom gibi patolojilerin tedavisinde kullanılan bifosfanatların ve benzeri özellikteki antianjiojenik ve antirezorptif ilaçların istenmeyen bir yan etkisi çenelerde görülen osteonekrozdur. Bu çalışmada amaç diş hekimliği öğrencilerinin ilaçla ilişkili çene osteonekrozu (MRONJ) ile ilgili bilgi düzeylerini değerlendirmek, farkındalık oluşturmak aynı zamanda diş hekimliğinde MRONJ’un önemini vurgulamaktır. Gereç ve Yöntemler: Çalışma için gerekli etik onay alındıktan sonra öğrencilere anket çalışması hakkında bilgi verilmiştir. MRONJ tanımı, bifosfanat ve benzeri ilaçların kullanım endikasyonları, ilaçların kullanım süresi, dozajı ve kullanım şeklinin önemini sorgulayan, 10 sorudan oluşan anket soruları çalışmaya katılmayı kabul eden öğrencilere dağıtılmış, cevaplama sırasında herhangi bir veri kaynağına izin verilmemiştir. Verilerin analizi IBM SPSS 25 programı kullanılarak yapılmıştır. Bulgular: Çalışmaya 102 4.sınıf öğrencisi, 100 5.sınıf öğrencisi olmak üzere toplam 202 öğrenci katılmıştır. Terminolojinin sorgulandığı ilk soruda en fazla bilinen terimin % 98’lik oranla BRONJ olduğu görülmektedir. MRONJ tanısı için gerekli üç kriteri de doğru cevaplayan 42 öğrenci, hiçbir kriteri cevaplamayan 36 öğrenci mevcuttur. Bu kriterlerin tamamını bilen öğrencilerin diğer sorulara daha doğru cevaplar verdiği görülmüştür. Sonuçlar: Bu çalışma öğrencilerin tamamına yakınının anamnezde çene osteonekrozuna neden olan ilaç kullanımını sorgulamayı ve hastaların bu ilaçlarla tedaviye başlamadan önce diş hekimine muayene olmalarını önemli gördüğünü göstermektedir. Bununla birlikte MRONJ tanısı, risk faktörleri, neden olan ilaçlar ve kullanıldığı hastalıklar yönünden yeterli bilgi düzeyine sahip olmadıkları da görülmektedir. Anahtar Kelimeler: Osteonekroz, bifosfonat, denosumab

Keywords

• Osteonekroz
• bifosfonat
• denosumab

Evaluation of Dentistry Students' Knowledge About the Medication-Related Osteonecrosis of the Jaw (MRONJ)

Abstract

Background: An undesirable side effect of bisphosphonates and similar antiangiogenic and antiresorptive drugs used in the treatment of pathologies such as osteoporosis, Paget's disease, and multiple myeloma, especially in the treatment of cancer patients with bone metastasis, is osteonecrosis of the jaws. The aim of this study is to evaluate the knowledge level of dentistry students about medication-related osteonecrosis of the jaw (MRONJ), to raise awareness and to emphasize the importance of MRONJ in dentistry. Methods: After obtaining the necessary ethical approval for the study, the students were informed about the survey study. Questionnaires consisting of 10 questions, questioning the definition of MRONJ, indications for use of bisphosphonate and similar drugs, duration of use, dosage and the importance of use of drugs, were distributed to the students who agreed to participate in the study, and no data source was allowed during the answering process. Data analysis was done using IBM SPSS 25 program. Results: A total of 202 students, 102 4th grade students and 100 5th grade students participated in the study. In the first question in which the terminology is questioned, it is seen that the most known term is BRONJ with a rate of 98%. There are 42 students who correctly answered all three criteria for the diagnosis of MRONJ, and 36 students who did not answer any of the criteria. It was observed that the students who knew all of these criteria gave more correct answers to the other questions. Conclusion: This study shows that almost all of the students consider it important to question the use of drugs that cause osteonecrosis of the jaw in the anamnesis and to see the dentist before starting treatment with these drugs. However, it is also seen that they do not have sufficient knowledge in terms of the diagnosis of MRONJ, risk factors, causative drugs and diseases that are used.

Keywords

• osteonecrosis
• biphosphonate
• denosumab

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