KÖK HÜCRELER VE DİŞ HEKİMLİĞİ: LİTERATÜR DERLEMESİ
Yıl 2019,
Cilt: 6 Sayı: 1, 73 - 81, 01.04.2019
Kübra Gülnur Topsakal
,
Yasemin Nur Korkmaz
Öz
Kök hücreler, hem rejeneratif tıp uygulamalarında
hem de doku rejenerasyonunda kullanılan ve dental dokular da dahil olmak üzere
çok çeşitli doku ve organlardan izole edilen prekürsör hücrelerdir. Hem doku
mühendisliğinde hem de klinik uygulamalarda kullanılan kök hücreler,
odontoblastlardan nöral hücrelere kadar birçok hücreye dönüşebilme yeteneğine
sahiptir. Diş hekimliği alanında yetişkin mezenkimal kök hücreler çeşitli oral
ve maksillofasiyal dokularda tanımlanmıştır; bu da oral dokuların kök
hücrelerden zengin olduğunu ve mukozal hücrelerin indükte pluripotent kök
hücreler gibi genetik olarak yeniden programlanmış hücreler için ideal kaynak
olabileceğini göstermiştir. Ayrıca oral dokuların kök hücreler için yalnızca
bir kaynak değil, aynı zamanda terapötik bir hedef olması da beklenmektedir. Bu
derlemede, diş hekimliği alanındaki klinik kullanılabilirlik ve uygulamalar
açısından çeşitli intra ve ekstraoral doku kökenli kök hücre tiplerine ve
rejeneratif diş hekimliği için uygun kök hücrelere genel bir bakış açısı
sunulmaktadır.
Kaynakça
- 1. Slack J. Origin of stem cells in organogenesis. Science. 2008;322(5907):1498-501.
- 2. Vacanti JP, Langer R. Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet. 1999;354:S32-S4.
- 3. Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry–part I: stem cell sources. J Prosthodont Res. 2012;56(3):151-65.
- 4. Kaigler D, Mooney D. Tissue engineering's impact on dentistry. J Dent Educ. 2001;65(5):456-62.
- 5. Koyano K. Toward a new era in prosthodontic medicine. J Prosthodont Res. 2012;56(1):1-2.
- 6. Kirkwood KL. . Periodontal Diseases and Oral Bone Loss. Primer on the metabolic bone diseases and disorders of mineral metabolism. 2008:510-3.
- 7. Atwood DA. Reduction of residual ridges: a major oral disease entity. J Prosthet Dent. 1971;26(3):266-79.
- 8. Darby I, Chen S, De Poi R. Ridge preservation: what is it and when should it be considered. Aust Dent J. 2008;53(1):11-21.
- 9. Egusa H, Saeki M, Doi M, Fukuyasu S, Matsumoto T, Kamisaki Y, et al. A small-molecule approach to bone regenerative medicine in dentistry. J Oral Biosci. 2010;52(2):107-18.
- 10. Egusa H. [iPS cells in dentistry]. Clin Calcium. 2012;22(1):67-73.
- 11. Lin NH, Gronthos S, Mark Bartold P. Stem cells and future periodontal regeneration. Periodontol 2000. 2009;51(1):239-51.
- 12. Izumi Y, Aoki A, Yamada Y, Kobayashi H, Iwata T, Akizuki T, et al. Current and future periodontal tissue engineering. Periodontol 2000. 2011;56(1):166-87.
- 13. Ueda M, Yamada Y, Kagami H, Hibi H. Injectable bone applied for ridge augmentation and dental implant placement: human progress study. Implant Dent. 2008;17(1):82-90.
- 14. Yamada Y, Nakamura S, Ito K, Kohgo T, Hibi H, Nagasaka T, et al. Injectable tissue-engineered bone using autogenous bone marrow–derived stromal cells for maxillary sinus augmentation: clinical application report from a 2–6-year follow-up. Tissue Eng Part A. 2008;14(10):1699-707.
- 15. Oshima M, Mizuno M, Imamura A, Ogawa M, Yasukawa M, Yamazaki H, et al. Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy. PloS one. 2011;6(7):e21531.
- 16. Lombaert IM, Knox SM, Hoffman MP. Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration. Oral Dis. 2011;17(5):445-9.
- 17. Luxameechanporn T, Hadlock T, Shyu J, Cowan D, Faquin W, Varvares M. Successful myoblast transplantation in rat tongue reconstruction. Head Neck. 2006;28(6):517-24.
- 18. Shah R, Sinanan A, Knowles J, Hunt N, Lewis M. Craniofacial muscle engineering using a 3-dimensional phosphate glass fibre construct. Biomaterials. 2005;26(13):1497-505.
- 19. Yu H, Yang X, Cheng J, Wang X, Shen SG. Distraction osteogenesis combined with tissue-engineered cartilage in the reconstruction of condylar osteochondral defect. J Maxillofac Oral Surg. 2011;69(12):e558-e64.
- 20. Yamada Y, Ueda M, Hibi H, Baba S. A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report. Int J Periodontics Restorative Dent. 2006;26(4).
- 21. Kubo T, Doi K, Hayashi K, Morita K, Matsuura A, Teixeira ER, et al. Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxylapatite. A beagle dog study. J Prosthodont Res 2011;55(2):104-9.
- 22. YAMANKOÇ G, Gamze A. İNSAN DİŞLERİNİN DOKU MÜHENDİSLİĞİNDEKİ ÖNEMİ THE IMPORTANCE OF HUMAN TEETH IN TISSUE ENGINEERING. Istanbul Univ Dishekim Fak Derg 2010;44(1):33.
- 23. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. cell. 2007;131(5):861-72.
- 24. Horwitz E, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, et al. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy. 2005;7(5):393-5.
- 25. Egusa H, Iida K, Kobayashi M, Lin TY, Zhu M, Zuk PA, et al. Downregulation of extracellular matrix-related gene clusters during osteogenic differentiation of human bone marrow-and adipose tissue-derived stromal cells. Tissue Eng. 2007;13(10):2589-600.
- 26. Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng. 2004;32(1):160-5.
- 27. Harada H, Kettunen P, Jung H-S, Mustonen T, Wang YA, Thesleff I. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol. 1999;147(1):105-20.
- 28. Butler WT, Ritchie HH, Bronckers AL, editors. Extracellular matrix proteins of dentine. Ciba Foundation Symposium 205-Dental Enamel; 1997: Wiley Online Library.
- 29. Ruch JV. Odontoblast commitment and differentiation. Biochem Cell Biol. 1998;76(6):923-38.
- 30. Nevins M, Kao RT, McGuire MK, McClain PK, Hinrichs JE, McAllister BS, et al. Platelet-derived growth factor promotes periodontal regeneration in localized osseous defects: 36-month extension results from a randomized, controlled, double-masked clinical trial. J Periodontol. 2013;84(4):456-64.
- 31. Kitamura C, Kimura K, Nakayama T, Terashita M. Temporal and spatial expression of c-jun and jun-B proto-oncogenes in pulp cells involved with reparative dentinogenesis after cavity preparation of rat molars. J Dent Res. 1999;78(2):673-80.
- 32. Akiyama K, Chen C, Gronthos S, Shi S. Lineage differentiation of mesenchymal stem cells from dental pulp, apical papilla, and periodontal ligament. Odontogenesis: Methods and Protocols. 2012:111-21.
- 33. Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364(9429):149-55.
- 34. Gronthos S, Mrozik K, Shi S, Bartold P. Ovine periodontal ligament stem cells: isolation, characterization, and differentiation potential. Calcif Tissue Int. 2006;79(5):310-7.
- 35. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one. 2006;1(1):e79.
- 36. Seo B-M, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 2005;84(10):907-12.
- 37. Wang L, Shen H, Zheng W, Tang L, Yang Z, Gao Y, et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Eng Part A. 2010;17(7-8):1015-26.
- 38. Ten Cate A. The role of epithelium in the development, structure and function of the tissues of tooth support. Oral Dis. 1996;2(1):55-62.
- 39. Modino SA, Sharpe PT. Tissue engineering of teeth using adult stem cells. Arch Oral Biol. 2005;50(2):255-8.
- 40. Stanislawski L, Carreau J, Pouchelet M, Chen Z, Goldberg M. In vitro culture of human dental pulp cells: some aspects of cells emerging early from the explant. Clin Oral Investig. 1997;1(3):131-40.
- 41. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci. 2000;97(25):13625-30.
- 42. Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. J Dent Res. 2002;81(8):531-5.
- 43. Kerkis I, Kerkis A, Dozortsev D, Stukart-Parsons GC, Gomes Massironi S, Pereira LV, et al. Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs. 2007;184(3-4):105-16.
- 44. Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. J Endod. 2007;33(4):377-90.
- 45. Sloan A, Smith A. Stem cells and the dental pulp: potential roles in dentine regeneration and repair. Oral Dis. 2007;13(2):151-7.
- 46. Jo Y-Y, Lee H-J, Kook S-Y, Choung H-W, Park J-Y, Chung J-H, et al. Isolation and characterization of postnatal stem cells from human dental tissues. Tissue Eng. 2007;13(4):767-73.
- 47. Garant PR. Oral cells and tissues: Quintessence Publishing (IL); 2003.
- 48. Izumi K, Tobita T, Feinberg S. Isolation of human oral keratinocyte progenitor/stem cells. J Dent Res. 2007;86(4):341-6.
- 49. Izumi K, Feinberg SE, Terashi H, Marcelo CL. Evaluation of transplanted tissue-engineered oral mucosa equivalents in severe combined immunodeficient mice. Tissue Eng. 2003;9(1):163-74.
- 50. Izumi K, Feinberg S, Iida A, Yoshizawa M. Intraoral grafting of an ex vivo produced oral mucosa equivalent: a preliminary report. Int J Oral Maxillofac Surg. 2003;32(2):188-97.
- 51. Fell HB. The osteogenic capacity in vitro of periosteum and endosteum isolated from the limb skeleton of fowl embryos and young chicks. J Anat. 1932;66(Pt 2):157.
- 52. Allen MR, Hock JM, Burr DB. Periosteum: biology, regulation, and response to osteoporosis therapies. Bone. 2004;35(5):1003-12.
- 53. Wang Q, Huang C, Zeng F, Xue M, Zhang X. Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol. 2010;177(6):3100-11.
- 54. Ball MD, Bonzani IC, Bovis MJ, Williams A, Stevens MM. Human periosteum is a source of cells for orthopaedic tissue engineering: a pilot study. Clin Orthop Relat Res. 2011;469(11):3085-93.
- 55. Man YG, Ball WD, Marchetti L, Hand AR. Contributions of intercalated duct cells to the normal parenchyma of submandibular glands of adult rats. Anat Rec. 2001;263(2):202-14.
- 56. Kishi T, Takao T, Fujita K, Taniguchi H. Clonal proliferation of multipotent stem/progenitor cells in the neonatal and adult salivary glands. Biochem Biophys Res Commun. 2006;340(2):544-52.
- 57. Matsumoto S, Okumura K, Ogata A, Hisatomi Y, Sato A, Hattori K, et al. Isolation of tissue progenitor cells from duct-ligated salivary glands of swine. Cloning Stem Cells. 2007;9(2):176-90.
- 58. Sato A, Okumura K, Matsumoto S, Hattori K, Hattori S, Shinohara M, et al. Isolation, tissue localization, and cellular characterization of progenitors derived from adult human salivary glands. Cloning Stem Cells. 2007;9(2):191-205.
- 59. Nanduri LS, Maimets M, Pringle SA, van der Zwaag M, van Os RP, Coppes RP. Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother Oncol. 2011;99(3):367-72.
- 60. Mizuno H, Tobita M, Orbay H, Uysal AC, Lu F. Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine. Stem Cells and Cancer Stem Cells, Volume 12: Springer; 2014. p. 165-74.
- 61. Peng L, Jia Z, Yin X, Zhang X, Liu Y, Chen P, et al. Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev. 2008;17(4):761-74.
- 62. Mesimäki K, Lindroos B, Törnwall J, Mauno J, Lindqvist C, Kontio R, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg. 2009;38(3):201-9.
- 63. Pieri F, Lucarelli E, Corinaldesi G, Aldini NN, Fini M, Parrilli A, et al. Dose-dependent effect of adipose-derived adult stem cells on vertical bone regeneration in rabbit calvarium. Biomaterials. 2010;31(13):3527-35.
- 64. Tobita M, Uysal AC, Ogawa R, Hyakusoku H, Mizuno H. Periodontal tissue regeneration with adipose-derived stem cells. Tissue Eng Part A. 2008;14(6):945-53.
- 65. Ishizaka R, Iohara K, Murakami M, Fukuta O, Nakashima M. Regeneration of dental pulp following pulpectomy by fractionated stem/progenitor cells from bone marrow and adipose tissue. Biomaterials. 2012;33(7):2109-18.
- 66. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-7.
- 67. Wobus AM, Boheler KR. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol Rev. 2005;85(2):635-78.
- 68. Shamis Y, Hewitt KJ, Carlson MW, Margvelashvilli M, Dong S, Kuo CK, et al. Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents. Stem Cell Res Ther. 2011;2(1):1.
- 69. Kang HK, Roh S, Lee G, Hong S-D, Kang H, Min B-M. Osteogenic potential of embryonic stem cells in tooth sockets. Int J Mol Med. 2008;21(5):539-44.
- 70. Inanç B, Elçin AE, Elçin YM. In vitro differentiation and attachment of human embryonic stem cells on periodontal tooth root surfaces. Tissue Eng Part A. 2009;15(11):3427-35.
- 71. Ning F, Guo Y, Tang J, Zhou J, Zhang H, Lu W, et al. Differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned medium. Biochem Biophys Res Commun. 2010;394(2):342-7.
- 72. Bluteau G, Luder H, De Bari C, Mitsiadis T. Stem cells for tooth engineering. Eur Cell Mater. 2008;16(1):9.
- 73. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci. 2003;100(10):5807-12.
- 74. Seo B, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, et al. SHED repair critical‐size calvarial defects in mice. Oral Dis. 2008;14(5):428-34.
- 75. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. cell. 2006;126(4):663-76.
- 76. Yan X, Qin H, Qu C, Tuan RS, Shi S, Huang GT-J. iPS cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Dev. 2010;19(4):469-80.
- 77. Duan X, Tu Q, Zhang J, Ye J, Sommer C, Mostoslavsky G, et al. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol. 2011;226(1):150-7.
- 78. Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, et al. Role of epithelial-stem cell interactions during dental cell differentiation. J Biol Chem. 2012;287(13):10590-601.
- 79. Otsu K, Kishigami R, Oikawa-Sasaki A, Fukumoto S, Yamada A, Fujiwara N, et al. Differentiation of induced pluripotent stem cells into dental mesenchymal cells. Stem Cells Dev. 2011;21(7):1156-64.
- 80. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010;28(8):848-55.
- 81. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439(7079):993-7.
- 82. Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, et al. Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell stem cell. 2010;6(1):25-36.
- 83. Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature. 2011;472(7341):51-6.
- 84. Marynka‐Kalmani K, Treves S, Yafee M, Rachima H, Gafni Y, Cohen MA, et al. The lamina propria of adult human oral mucosa harbors a novel stem cell population. Stem Cells. 2010;28(5):984-95.
- 85. Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, et al. Gingival fibroblasts as a promising source of induced pluripotent stem cells. PloS one. 2010;5(9):e12743.
- 86. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110(10):3499-506.
- 87. Rasmusson I, Uhlin M, Le Blanc K, Levitsky V. Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes. J Leukoc Biol. 2007;82(4):887-93.
- 88. ÖZCAN E, ÖZCAN DSSA. Periodontal rejenerasyonda kök hücrenin yeri. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2010;2010(2).