Papillon LeFèvre Sendromlu Hastalarda Alveoler Soket Koruma Yöntemi Olarak İmplant Yerleştirilmesi; İki Olgu Sunumu

Yıl 2021, Cilt: 8 Sayı: 1, 205 - 210, 30.04.2021

Emine Elif Mutafcilar Elif İnönü Recep Dursun Sema Sezgin Hakkı

https://doi.org/10.15311/selcukdentj.654068

Öz

Papillon-Lefèvre sendromu, süt ve daimî dentisyonda erken diş kaybı ve palmaplantar hiperkeratoz ile karakterize otozomal resesif geçişli genetik bir hastalıktır. Bu olgu raporunda, Papillon-Lefèvre sendromlu (PLS) iki hastada, alveolar kemiği korumak için diş köklerinin dişeti altında bırakılması ve çekimlerini takiben çekim soketinin implant ile korunması sunuldu. PLS tanısı konmuş 18 yaşında erkek ve 29 yaşında kadın hasta Selçuk Üniversitesi Periodontoloji Anabilim Dalı kliniğinde 11-12 yaşlarından itibaren takip edilerek periodontal tedavi ile dişlerin ağızda tutulmasına çalışılmıştır. Şiddetli mobilitesi olan dişler çekildikten sonra birçok kez protezleri yenilenmiştir. 43 ve 33 nolu diş köklerinin diş eti altında bırakılmasının ardından kökler yaklaşık 5 yıl boyunca ağızda tutulabilmiştir. Dişlerin ağız ortamına açıldıktan sonra kaybedilmesinin ardından alveolar kemiğin korunması amacıyla aynı bölgelere dental implant yerleştirilerek alveolar kemik rezorpsiyonu riski nedeniyle dişeti altında bırakılmıştır. Klinik ve radyografik olarak kontrol edilen hastalarda yumuşak doku komplikasyonu gözlenmeksizin ve dişsiz sahalara kıyasla kemik seviyesi korunabilmiştir.

Anahtar Kelimeler

implant, Papillon- Lefèvre Sendromu, Peridontitis

Kaynakça

• 1. Sreeramulu B, Haragopal S, Shalini K, Sudha MD, Kiran G. The prosthodontic management of a young edentulous patient with the papillon lefevre syndrome-a rare case report. J Clin Diagn Res. 2012;6(10):1808–1811. 2. Wani AA, Devkar N, Patole MS, Shouche YS. Description of two new cathepsin C gene mutations in patients with Papillon-Lefèvre syndrome. J Periodontol. 2006;77:233–237. 3. Hattab FN, Rawashdeh MA, Yassin OM, al-Momani AS, al-Ubosi M. Papillon-Lefèvre syndrome: a review of the literature and report of 4 cases. J Periodontol. 1995;66:413–420. 4. Almuneef M, Al Khenaizan S, Al Ajaji S, Al Anazi A. Pyogenic liver abscess and Papillon-Lefèvre syndrome: not a rare association. Pediatrics. 2003;111:e85–e88. 5. Toomes C, James J, Wood AJ, et al. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat Genet. 1999;23:421–424. 6. Ghaffer KA, Zahran FM, Fahmy HM, Brown RS. Papillon-Lefèvre syndrome: neutrophil function in 15 cases from 4 families in Egypt. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:320–325. 7. Liu R, Cao C, Meng H, Tang Z. Leukocyte function in 2 cases of Papillon-Lefèvre syndrome. J Clin Periodontol. 2000;27:69–73. 8. Kleinfelder JW, Topoll HH, Preus HR, Müller RF, Lange DE, Böcker W. Microbiological and immunohistological findings in a patient with Papillon-Lefèvre syndrome. J Clin Periodontol. 1996;23:1032–1038. 9. Hewitt C, McCormick D, Linden G, Turk D, Stern I, Wallace I, et al. The role of cathepsin C in Papillon‐Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Human mutation. 2004;23(3):222-8. 10. Hattab FN. Papillon-Lefèvre syndrome: from then until now. 2019. 11. Lundgren T, Parhar RS, Renvert S, Tatakis DN. Impaired cytotoxicity in Papillon Lefèvre syndrome. J Dent Res. 2005;84:414–417. 12. de Haar SF, Hiemstra PS, van Steenbergen MT, Everts V, Beertsen W. Role of polymorphonuclear leukocyte derived serine proteinases in defense against Actinobacillus actinomycetemcomitans. Infect Immun. 2006;74:5284–5291. 13. Hart TC, Shapira L. Papillon‐Lefèvre syndrome. Periodontology 2000. 1994;6(1):88-100. 14. Glenwright HD, Rock WP. Papillon-Lefevre syndrome: A discussion of aetiology and a case report. Br Dent J. 1990;168:27–29. 15. Hattab FN, Rawashdeh MA, Yassin OM, al-Momani AS, al-Ubosi MM.Papillon-Lefèvre syndrome: a review of the literature and report of 4 cases. J Periodontol 1995;66:413-20. 16. Pareek SS, Al-Aska AK. Papillon-Lefevre syndrome. A report of six cases in one family. Int J Dermatol. 1986;25:638–641. 17. Sreeramulu B, Shyam ND, Ajay P, Suman P. Papillon–Lefèvre syndrome: clinical presentation and management options. Clinical, cosmetic and investigational dentistry. 2015;7:75 18. Yacoub AA, Hattab FN. Oral and dermatologic findings in two siblings with Papillon-Lefevre syndrome: review of the literature. Qatar Med J 2008;17:63-7. 19. Sachdeva S, Kalra N, Kapoor P. Papillon-Lefèvre syndrome: report of a case and its management. J Clin Exp Dent 2012;4:e77-81. 20. Ullbro C, Crossner CG, Nederfors T, Alfadley A, Thestrup-Pedersen K. Dermatological and oral findings in a cohort of 47 patients with Papillon-Lefèvre syndrome. J Am Acad Dermatol 2003;48:345-51. 21. Shah J, Goel S. Papillon–Lefèvre syndrome: two case reports. Indian J Dent Res. 2007;18:210–213. 22. Lu HK, Lin CT, Kwan HW. Treatment of a patient with Papillon-Lefèvre syndrome. A case report. J Periodontol. 1987;58:789–793. 23. Dhanrajani PJ. Papillon-Lefevre syndrome: clinical presentation and a brief review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:e1–e7. 24. Cagli NA, Hakki SS, Dursun R, Toy H, Gokalp A, Ryu OH, Hart PS, Hart TC. Clinical, genetic, and biochemical findings in two siblings with Papillon-Lefèvre Syndrome. J Periodontol. 2005 Dec;76(12):2322-9. 25. Gorlin RJ: Of palms, soles, and gums. J Med Genet 37:82, 2000 26. Lundgren T, Renvert S: Periodontal treatment of patients with Papillon-Lefèvre syndrome: A 3-year follow-up. J Clin Periodontol 31:933, 2004 27. Senel FC, Altintas NY, Bagis B, Cankaya M, Pampu AA, Satıroglu I, et al. A 3-year follow-up of the rehabilitation of Papillon-Lefèvre syndrome by dental implants. Journal of Oral and Maxillofacial Surgery. 2012;70(1):163-7 28. Preus, Hans, and Per %J Journal of Clinical Periodontology Gjermo. 1987. 'Clinical management of prepubertal periodontitis in 2 siblings with Papillon‐Lefèvre syndrome', 14: 156-60.28. 29. Preus, Hans R %J Journal of clinical periodontology. 1988. 'Treatment of rapidly destructive periodontitis in Papillon‐Lefèvre syndrome: Laboratory and clinical observations', 15: 639-43 30. Sloan, P, JV Soames, JJ Murray, and WMM %J Journal of periodontology Jenkins. 1984. 'Histopathological and ultrastructural findings in a case of Papillon‐Lefevre syndrome', 55: 482-85. 31. Tinanoff N, Tempro P, Maderazo EG. Dental treatment of Papillon-Lefèvre syndrome: 15-year follow-up. J Clin Periodontol 1995;22:609-12 32. Preus H, Gjermo P. Clinical management of prepubertal periodontitis in 2 siblings with Papillon-Lefévre syndrome. J Clin Periodontol 1987;14:156-60. 33. Glenwright HD, Rock WP. Papillon-Lefevre syndrome: a discussion of aetiology and a case report. Br Dent J 1990;168:27-9. 34. Nickles, Katrin, Beate Schacher, Petra Ratka‐Krüger, Mischa Krebs, and Peter %J Journal of clinical periodontology Eickholz. 2013. 'Long‐term results after treatment of periodontitis in patients with Papillon–Lefèvre syndrome: success and failure', 40: 789-98