Olgu Sunumu
BibTex RIS Kaynak Göster

An Etiologic Perspective on Late Diagnosed Oral Squamous Cell Carcinoma: A Case Report

Yıl 2024, Cilt: 11 Sayı: 3, 341 - 345, 23.12.2024
https://doi.org/10.15311/selcukdentj.1410479

Öz

In malign neoplasms, oral squamous cell carcinoma (OSCC) is one of the important causes of mortality and morbidity. For this reason, early diagnosis of OSCC is of great importance. Since the first symptoms of OSCC cases are asymptomatic ulcers or painless swelling, it is known that there may be a delay in the diagnostic process due to both patient- and physician-related factors. In this case report, a 71-year-old woman was admitted to our clinic with the complaint of intraoral ulceration that had not healed for 6 months. In the anamnesis, it was learned that a tooth extraction procedure was performed six months ago due to pain and tenderness in the left mandibular region, but the complaints persisted. Intraoral examination revealed a painful ulcerated lesion on the left mandibular crest with irregular borders and a tendency to bleed. After incisional biopsy of the alveolar crest mucosa and underlying necrotic bone, histopathologic evaluation revealed a diagnosis of well-differentiated OSCC.
Key Words: Delayed Diagnosis; Etiology; Oral Ulcer; Squamous Cell Cancer

Kaynakça

  • 1. Muller S, Tilakaratne WM. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue. Head Neck Pathol. 2022;16(1):54-62. doi:10.1007/s12105-021-01402-9
  • 2. Günhan Ç. Oral ve Maksillofasiyal Patoloji. 1.baskı. Quintessence Yayıncılık; 2015.
  • 3. Chamoli A, Gosavi AS, Shirwadkar UP, et al. Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics. Oral Oncol. 2021;121:105451. doi:10.1016/j.oraloncology.2021.105451
  • 4. Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015;24(3):491-508. doi:10.1016/j.soc.2015.03.006
  • 5. Laskaris G. Color Atlas of Oral Diseases: Diagnosis and Treatment. 4.baskı. Thieme; 2017.
  • 6. Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primer. 2020;6(1):92. doi:10.1038/s41572-020-00224-3
  • 7. Ci̇ndoruk S sıddık. Havadaki NO ve NO2 Parametrelerinin Marmara Temiz Hava Merkezi Ölçümleri Kapsaminda İncelenmesi. Niğde Ömer Halisdemir Üniversitesi Mühendis Bilim Derg. 2018;7(2):600-611. doi:10.28948/ngumuh.443194
  • 8. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol. 2010;46(6):414-417. doi:10.1016/j.oraloncology.2010.03.009
  • 9. Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J. 2006;85(2):74.
  • 10. Ettinger KS, Ganry L, Fernandes RP. Oral Cavity Cancer. Oral Maxillofac Surg Clin N Am. 2019;31(1):13-29. doi:10.1016/j.coms.2018.08.002
  • 11. Togni L, Mascitti M, Vignigni A, et al. Treatment-Related Dysgeusia in Oral and Oropharyngeal Cancer: A Comprehensive Review. Nutrients. 2021;13(10):3325. doi:10.3390/nu13103325
  • 12. Basu S, Hess S, Nielsen Braad PE, Olsen BB, Inglev S, Høilund-Carlsen PF. The Basic Principles of FDG-PET/CT Imaging. PET Clin. 2014;9(4):355-370, v. doi:10.1016/j.cpet.2014.07.006
  • 13. Massano J, Regateiro FS, Januário G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(1):67-76. doi:10.1016/j.tripleo.2005.07.038
  • 14. Zanoni DK, Patel SG, Shah JP. Changes in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging of Head and Neck Cancer: Rationale and Implications. Curr Oncol Rep. 2019;21(6):52. doi:10.1007/s11912-019-0799-x
  • 15. Wreesmann VB, Katabi N, Palmer FL, et al. Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma. Head Neck. 2016;38 Suppl 1(Suppl 1):E1192-1199. doi:10.1002/hed.24190
  • 16. Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93-99. doi:10.3322/caac.21388
  • 17. Taş A, Yilmaz S, Si̇Ndel A. Oral Skuamoz Hücreli Karsinom – 3 Olgu Sunumu. Osman J Med. 2020;42(5):142-147. doi:10.20515/otd.770228
  • 18. Hakim SG, Wieker H, Trenkle T, et al. Imaging of mandible invasion by oral squamous cell carcinoma using computed tomography, cone-beam computed tomography and bone scintigraphy with SPECT. Clin Oral Investig. 2014;18(3):961-967. doi:10.1007/s00784-013-1042-z
  • 19. Junn JC, Soderlund KA, Glastonbury CM. Imaging of Head and Neck Cancer With CT, MRI, and US. Semin Nucl Med. 2021;51(1):3-12. doi:10.1053/j.semnuclmed.2020.07.005
  • 20. Pires FR, Ramos AB, Oliveira JBC de, Tavares AS, Luz PSR da, Santos TCRB dos. Oral squamous cell carcinoma: clinicopathological features from 346 cases from a single oral pathology service during an 8-year period. J Appl Oral Sci Rev FOB. 2013;21(5):460-467. doi:10.1590/1679-775720130317
  • 21. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002;52(4):195-215. doi:10.3322/canjclin.52.4.195
  • 22. Onizawa K, Nishihara K, Yamagata K, Yusa H, Yanagawa T, Yoshida H. Factors associated with diagnostic delay of oral squamous cell carcinoma. Oral Oncol. 2003;39(8):781-788. doi:10.1016/s1368-8375(03)00075-7
  • 23. Seoane J, Takkouche B, Varela-Centelles P, Tomás I, Seoane-Romero JM. Impact of delay in diagnosis on survival to head and neck carcinomas: a systematic review with meta-analysis. Clin Otolaryngol Off J ENT-UK Off J Neth Soc Oto-Rhino-Laryngol Cervico-Facial Surg. 2012;37(2):99-106. doi:10.1111/j.1749-4486.2012.02464.x
  • 24. Jafari A, Najafi S, Moradi F, Kharazifard M, Khami M. Delay in the Diagnosis and Treatment of Oral Cancer. J Dent. 2013;14(3):146-150.

Geç Tanı Konulmuş Oral Sküamoz Hücreli Karsinom Üzerine Etiyolojik Bir Bakış: Bir Olgu Sunumu

Yıl 2024, Cilt: 11 Sayı: 3, 341 - 345, 23.12.2024
https://doi.org/10.15311/selcukdentj.1410479

Öz

Malign neoplazmlar arasında oral sküamoz hücreli karsinom (OSHK) mortalite ve morbiditeye sebep olan en önemli nedenler arasında yer almaktadır. Bu sebeple OSHK olgularında erken tanı büyük bir önem kazanmaktadır. OSHK olgularının ilk belirtilerinin asemptomatik ülser ya da ağrısız şişlik olması nedeniyle, tanı sürecinde hem hasta hem de hekim kaynaklı faktörler sebebiyle gecikme yaşanabileceği bilinmektedir. Bu olgu sunumunda 6 aydır iyileşmeyen intraoral ülserasyon şikayetiyle kliniğimize başvuran 71 yaşındaki kadın hastadan alınan anamnezde, altı ay önce mandibular sol bölgede ağrı ve hassasiyet şikayeti sebebiyle diş çekim işlemi yapıldığı ancak şikayetlerinin devam ettiği öğrenilmiştir. Yapılan intraoral muayenede sol mandibular krette kanamaya meyilli, sınırları düzensiz ağrılı ülsere lezyon saptanmıştır. Alveolar kret mukozası ve altındaki nekrotik kemikten alınan insizyonel biyopsi sonrasında yapılan histopatolojik değerlendirme sonucunda iyi diferansiye OSHK tanısı konmuştur.
Anahtar Kelimeler: Etiyoloji; Gecikmeli Tanı; Oral Ülser; Yassı Hücreli Kanser

Kaynakça

  • 1. Muller S, Tilakaratne WM. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue. Head Neck Pathol. 2022;16(1):54-62. doi:10.1007/s12105-021-01402-9
  • 2. Günhan Ç. Oral ve Maksillofasiyal Patoloji. 1.baskı. Quintessence Yayıncılık; 2015.
  • 3. Chamoli A, Gosavi AS, Shirwadkar UP, et al. Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics. Oral Oncol. 2021;121:105451. doi:10.1016/j.oraloncology.2021.105451
  • 4. Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015;24(3):491-508. doi:10.1016/j.soc.2015.03.006
  • 5. Laskaris G. Color Atlas of Oral Diseases: Diagnosis and Treatment. 4.baskı. Thieme; 2017.
  • 6. Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primer. 2020;6(1):92. doi:10.1038/s41572-020-00224-3
  • 7. Ci̇ndoruk S sıddık. Havadaki NO ve NO2 Parametrelerinin Marmara Temiz Hava Merkezi Ölçümleri Kapsaminda İncelenmesi. Niğde Ömer Halisdemir Üniversitesi Mühendis Bilim Derg. 2018;7(2):600-611. doi:10.28948/ngumuh.443194
  • 8. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol. 2010;46(6):414-417. doi:10.1016/j.oraloncology.2010.03.009
  • 9. Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J. 2006;85(2):74.
  • 10. Ettinger KS, Ganry L, Fernandes RP. Oral Cavity Cancer. Oral Maxillofac Surg Clin N Am. 2019;31(1):13-29. doi:10.1016/j.coms.2018.08.002
  • 11. Togni L, Mascitti M, Vignigni A, et al. Treatment-Related Dysgeusia in Oral and Oropharyngeal Cancer: A Comprehensive Review. Nutrients. 2021;13(10):3325. doi:10.3390/nu13103325
  • 12. Basu S, Hess S, Nielsen Braad PE, Olsen BB, Inglev S, Høilund-Carlsen PF. The Basic Principles of FDG-PET/CT Imaging. PET Clin. 2014;9(4):355-370, v. doi:10.1016/j.cpet.2014.07.006
  • 13. Massano J, Regateiro FS, Januário G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(1):67-76. doi:10.1016/j.tripleo.2005.07.038
  • 14. Zanoni DK, Patel SG, Shah JP. Changes in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging of Head and Neck Cancer: Rationale and Implications. Curr Oncol Rep. 2019;21(6):52. doi:10.1007/s11912-019-0799-x
  • 15. Wreesmann VB, Katabi N, Palmer FL, et al. Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma. Head Neck. 2016;38 Suppl 1(Suppl 1):E1192-1199. doi:10.1002/hed.24190
  • 16. Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93-99. doi:10.3322/caac.21388
  • 17. Taş A, Yilmaz S, Si̇Ndel A. Oral Skuamoz Hücreli Karsinom – 3 Olgu Sunumu. Osman J Med. 2020;42(5):142-147. doi:10.20515/otd.770228
  • 18. Hakim SG, Wieker H, Trenkle T, et al. Imaging of mandible invasion by oral squamous cell carcinoma using computed tomography, cone-beam computed tomography and bone scintigraphy with SPECT. Clin Oral Investig. 2014;18(3):961-967. doi:10.1007/s00784-013-1042-z
  • 19. Junn JC, Soderlund KA, Glastonbury CM. Imaging of Head and Neck Cancer With CT, MRI, and US. Semin Nucl Med. 2021;51(1):3-12. doi:10.1053/j.semnuclmed.2020.07.005
  • 20. Pires FR, Ramos AB, Oliveira JBC de, Tavares AS, Luz PSR da, Santos TCRB dos. Oral squamous cell carcinoma: clinicopathological features from 346 cases from a single oral pathology service during an 8-year period. J Appl Oral Sci Rev FOB. 2013;21(5):460-467. doi:10.1590/1679-775720130317
  • 21. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002;52(4):195-215. doi:10.3322/canjclin.52.4.195
  • 22. Onizawa K, Nishihara K, Yamagata K, Yusa H, Yanagawa T, Yoshida H. Factors associated with diagnostic delay of oral squamous cell carcinoma. Oral Oncol. 2003;39(8):781-788. doi:10.1016/s1368-8375(03)00075-7
  • 23. Seoane J, Takkouche B, Varela-Centelles P, Tomás I, Seoane-Romero JM. Impact of delay in diagnosis on survival to head and neck carcinomas: a systematic review with meta-analysis. Clin Otolaryngol Off J ENT-UK Off J Neth Soc Oto-Rhino-Laryngol Cervico-Facial Surg. 2012;37(2):99-106. doi:10.1111/j.1749-4486.2012.02464.x
  • 24. Jafari A, Najafi S, Moradi F, Kharazifard M, Khami M. Delay in the Diagnosis and Treatment of Oral Cancer. J Dent. 2013;14(3):146-150.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Ağız, Diş ve Çene Radyolojisi, Oral Tıp ve Patoloji
Bölüm Olgu Sunumu
Yazarlar

Aytaç Üzel 0000-0001-7386-5660

Alican Kuran 0000-0001-9677-8690

Fatma Aksakallı 0000-0002-2380-1148

Berkay Tokuç 0000-0002-1149-2886

Umut Seki 0000-0002-0286-9792

Enver Alper Sinanoğlu 0000-0002-8349-3239

Yayımlanma Tarihi 23 Aralık 2024
Gönderilme Tarihi 26 Aralık 2023
Kabul Tarihi 27 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 3

Kaynak Göster

Vancouver Üzel A, Kuran A, Aksakallı F, Tokuç B, Seki U, Sinanoğlu EA. Geç Tanı Konulmuş Oral Sküamoz Hücreli Karsinom Üzerine Etiyolojik Bir Bakış: Bir Olgu Sunumu. Selcuk Dent J. 2024;11(3):341-5.