Akut Kolesistitte Kolesistektomi veya Kolesistostomi Yapılması Gerekecek Hastaların Ayırt Edilmesinde Biyolojik İndeksler Kullanılabilir mi?

Yıl 2022, , 489 - 495, 29.09.2022

Emre Gönüllü , Furkan Kucuk , Zulfu Bayhan , Ahmet Tarık Harmantepe , Recayi Capoglu

https://doi.org/10.31832/smj.1094111

Cited By: 1

Öz

Amaç: Başvuru sırasında acil ameliyat edilmeyip, medikal tedavi başlanan ve tedaviye yanıtsız grade 1-2 kolesistit hasta grubunda, acil kolesistektomi-kolesistostomi yapılacak hastaları belirlerken Nötrofil lenfosit oranının (NLR), Platelet-lenfosit oranının (PLR) ve Sistemik immün inflamatuar indeksin (SII) kullanılabileceğini göstermektir.
Gereç ve Yöntemler: Akut kolesistit nedeni ile yatırılan hastaların dosyaları retrospektif olarak taranarak kolesistostomi veya kolesistektomi ile tedavi edilen hastaların White blood cell, Platelet, C-Reaktif Protein değerleri, NLR, PLR, SII oranları, Ultrasonografik inceleme bulguları karşılaştırıldı.
Bulgular: 2019-2021 yılları arasında kolesistostomi yapılan 26 hasta, kolesistektomi yapılan 25 hastanın bulguları karşılaştırıldı. NLR (sırasıyla: 19.4 ∓ 26.5 vs 75.9 ∓ 94.5, p<0.05), PLR (sırasıyla: 268.6 ∓ 263.7 vs 153.5 ∓ 92.1, p<0.05), SII (sırasıyla: 4215.5 ∓ 5084.8 vs 1550.7 ∓ 2064.9, p<0.05) değerleri arasında anlamlı derecede farklılık saptandı
Sonuç: Medikal tedaviye yanıt vermeyen hastalarda kolesistostomi veya kolesistektomi yapılması kararı verilirken NLR, PLR, SII klinisyene yardımcı olabilir.

Anahtar Kelimeler

Nötrofil-lenfosit oranı, Platelet-lenfosit oranı, Sistemik İmmün İnflamatuar İndeks, Kolesistektomi, Perkütan kolesistostomi, Kolesistit

Kaynakça

• Knab, L. M., Boller, A.-M. & Mahvi, D. M. Cholecystitis. Surg. Clin. North Am. 2014;94:455–470.
• Kucuk, S. & Mızrak, S. Diagnostic Value of Inflammatory Factors in Patients with Gallbladder Cancer, Dysplasia, and Cholecystitis. Cancer Control 2021;28:108-112.
• Peery, A. F. et al. Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology 2015;149:1731–1741.
• Lee, S. O. & Yim, S. K. Management of acute cholecystitis. Korean J. Gastroenterol. 2018;71:264–268.
• Hirota, M. et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo Guidelines. J. Hepatobiliary. Pancreat. Surg. 2007;14:78–82.
• Mayumi, T. et al. Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. J. Hepatobiliary Pancreat. Sci. 2018;25:96–100.
• Yokoe, M. et al. Accuracy of the Tokyo Guidelines for the diagnosis of acute cholangitis and cholecystitis taking into consideration the clinical practice pattern in Japan. J. Hepatobiliary Pancreat. Sci. 2011;18:250–257.
• Yokoe, M. et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos). J. Hepatobiliary Pancreat. Sci. 2018;25:41–54.
• Song C. Y. et al. Correlation analysis of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and central cervical lymph node metastasis of papillary thyroid microcarcinoma. Zhonghua Zhong Liu Za Zhi 2021;43:944–948.
• Bilge, M., Akilli, I. K., Karaayvaz, E. B., Yesilova, A. & Kart Yasar, K. Comparison of systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized patients with malignancy, and their influence on mortality from COVID-19. Infect. Agent. Cancer 2021;16:60.
• Ozdemir, A., Kocak, S. Y., Karabela, S. N. & Yılmaz, M. [Can systemic immune inflammation index at admission predict in-hospital mortality in chronic kidney disease patients with SARS-CoV-2 infection]. Nefrologia 2021;09:122-123
• Takada, T. et al. TG13: Updated Tokyo Guidelines for the management of acute cholangitis and cholecystitis. Journal of Hepato-Biliary-Pancreatic Sciences vol. 2013;20:1–7.
• Loozen, C. S., Oor, J. E., van Ramshorst, B., van Santvoort, H. C. & Boerma, D. Conservative treatment of acute cholecystitis: a systematic review and pooled analysis. Surg. Endosc. 2017;31:504–515.
• Warttig, S., Ward, S., Rogers, G. & Guideline Development Group. Diagnosis and management of gallstone disease: summary of NICE guidance. BMJ 2014;349:6241.
• Shakir, T., Matwala, K., Vasan, A. & Karamanakos, S. Percutaneous Cholecystostomy for Acute Cholecystitis: A Three-Year Single-Centre Experience Including During COVID-19. Cureus 2021;13:20385.
• Esenboğa, K., Kurtul, A., Yamantürk, Y. Y., Tan, T. S. & Tutar, D. E. Systemic immune-inflammation index predicts no-reflow phenomenon after primary percutaneous coronary intervention. Acta Cardiol. 2021;1:1–8.
• Alifano, M. Systemic immune-inflammation index and prognosis of advanced non-small cell lung cancer. Annals of translational medicine vol. 2020;8:667.
• Zhang, D. et al. Systemic Immune-Inflammation Index for Predicting the Prognosis of Critically Ill Patients with Acute Pancreatitis. Int. J. Gen. Med. 2021;14:4491–4498.
• Asik, Z. The Role of the NLR and PLR in Urinary Tract Infection. Clin. Lab. 2021;1:67.
• Rajalingam, V. R. et al. The Role of Neutrophil-Lymphocyte-Ratio (NLR) and Platelet-Lymphocyte-Ratio (PLR) as a Biomarker for Distinguishing Between Complicated and Uncomplicated Appendicitis. Cureus 2022;14:21446.
• Kler, A., Taib, A., Hajibandeh, S., Hajibandeh, S. & Asaad, P. The predictive significance of neutrophil-to-lymphocyte ratio in cholecystitis: a systematic review and meta-analysis. Langenbecks. Arch. Surg. 2021;423:350-2.