Adjuvan radyoterapi uygulanan endometriyal kanser hastalarında sağkalım, nüks paternleri ve toksisite sonuçları

Abstract

Amaç: Bu çalışma, adjuvan radyoterapi uygulanan endometrium kanser (EK) hastalarının sağkalım sonuçlarını, nüks paternlerini ve tedaviye bağlı toksisiteleri araştırmayı amaçladı. Gereç ve Yöntemler: Ocak 2012-Aralık 2021 tarihleri arasında endometrium kanser tanısı ile adjuvan radyoterapi uygulanan 114 hasta retrospektif olarak incelendi. Vakalar, genel sağkalım (OS), hastalıksız sağkalım (DFS), lokal nükssüz sağkalım (LRFS), kansere özgü sağkalım (CSS) ve uzak metastazsız sağkalım (DMFS) açısından değerlendirildi. Bulgular: Medyan takip süresi 63 aydı (8 -135). 5 yıllık OS, DFS, LRFS, CSS ve DMFS, sırasıyla, %85.5, %90.5, %98.9, %94.1 ve %90.5 idi. Tek değişkenli analizde, lenfovasküler alan invazyonu (LVSI) ile DFS, DMFS ve CSS arasında istatistiksel olarak anlamlı bir ilişki vardı (sırasıyla, p=0,019, p=0,019, p=0,021). LRFS ile histoloji, tümör derecesi, evre ve brakiterapi uygulaması arasında anlamlı ilşki vardı. (sırasıyla, p=0,031, p=0,010, p=0,049, p=0,001). 40 hastada (%35.1), grade 1 ve 2 akut gastrointestinal toksisite gözlendi. 35 hastada (%30.7), grade 1 akut genitoüriner toksisite gözlendi. Grade 3 geç genitoüriner ve gastrointestinal toksisite sırasıyla %0.9 ve %1.8 oranında gözlendi. Sonuç: Histoloji, grade, LVSI, evre ve brakiterapi genel sağkalımı üzerinde anlamlı etkisi olmamasına karşın, LVSI ve evre nüks açısından en etkili prognostik faktörlerdi. Adjuvan radyoterapi güvenli ve kabul edilebilir toksisite ile endometriyum kanserli hastalar tarafından iyi tolere edilmektedir.

Keywords

• Endometrium kanseri
• Adjuvan radyoterapi
• Sağkalım
• Tedaviye bağlı toksisite

Supporting Institution

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Project Number

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Thanks

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Survival, Failure Patterns, and Toxicity Outcomes in Endometrial Cancer Patients Receiving Adjuvant Radiotherapy

Abstract

Objective: This study aimed to investigate the survival outcomes, recurrence patterns, and treatment-related toxicities of endometrial cancer (EC) patients who underwent adjuvant radiotherapy. Materials and Methods: Between January 2012 and December 2021, one hundred fourteen patients who underwent adjuvant radiotherapy with the diagnosis of endometrial cancer were retrospectively analyzed. Cases were evaluated for overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), cancer-specific survival (CSS), and distant metastasis-free survival (DMFS). Results: Median follow-up was 63 months (8 -135). At 5 years OS, DFS, LRFS, CSS, and DMFS were 85.5%, 90.5%, 98.9%, 94.1%, and 90.5%, respectively. Univariate analysis of lymphovascular space invasion (LVSI) is statistically significant for DFS, DMFS, and CSS, respectively (p=0.019, p=0.019, p=0.021) and histology, tumor grade, stage were statistically significant for LRFS, respectively (p=0.031, p=0.010, p=0.049). Grade 1 and 2 acute gastrointestinal toxicity were observed in 40 patients (35.1%). Grade 1 acute genitourinary toxicity was observed in 35 patients (30.7%). Grade 3 late genitourinary and gastrointestinal toxicity was observed in 0.9% and 1.8%, respectively. Conclusion: Histology, grade, LVSI, and stage didn’t significantly affect overall survival, but LVSI and stage were the most influential prognostic factors on relapse patterns. Adjuvant radiotherapy is safe and well tolerated by patients with endometrial cancer with acceptable toxicity.

Keywords

• Endometrial Cancer
• Adjuvant Radiotherapy
• Survival
• Treatment-related toxicity

Project Number

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