Kahramanmaraş Sütçü İmam Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi’nde Kan Kültürlerinden İzole Edilen Mikroorganizmalar ve Antibiyotik Duyarlılıkları

Yıl 2019, , 485 - 491, 16.09.2019

Burak Küçük , Gökhan Arıcan , Damla Gülderen Hacer Uğurlu Kezban Tülay Yalçınkaya Murat Aral

https://doi.org/10.31832/smj.595034

Öz

Kahramanmaraş Sütçü İmam Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi’nde kan kültürlerinden izole edilen mikroorganizmalar ve antibiyotik duyarlılıkları ÖZET Amaç: Kan dolaşımı enfeksiyonları, mortalite ve morbiditenin önde gelen nedenlerinden biridir. Çalışmamızın amacı kan kültürlerinde en sık belirlenen enfeksiyon etkenlerini ve antibiyotik duyarlılıklarını saptamaktır. Gereç ve Yöntem: 3719 izolat çalışmaya dahil edilmiştir. Kan kültürü örnekleri BACT/ALERT 3D otomatize sistemi ile inkübe edilmiştir. Üreyen mikroorganizmaların identifikasyonu ve antibiyotik duyarlılıkları Phoenix otomatize sistem ile yapılmıştır. Bulgular: En sık izole edilen Gram negatif bakteriler Escherichia coli 227 (%36.37), Klebsiella pneumoniae 126 (%20.19) olarak bulunmuştur. Gram pozitif bakterilerin 2245’inin koagülaz negatif Staphylococcus türleri, 251’inin (%8.8) Enterococcus spp., 194’ünün (%6.87)  Staphylococcus aureus olduğu saptanmıştır. Gram negatif bakterilere en etkili antibiyotikler karbapenemler, aminoglikozidler ve tigesiklin olarak bulunmuştur. Tüm Acinetobacter izolatları karbapenemlere dirençli bulunmuştur. Staphylococcus aureus izolatlarında vankomisin direnci saptanmazken metisilin direnci %55, koagülaz negatif Staphylococcus izolatlarında metisilin direnci %84 olarak bulunmuştur. Enterococcus spp. izolatlarında vankomisin direnci %9.7 olarak bulunmuştur. Sonuç: Sonuç olarak bakterilerin direnç oranlarının bu denli yüksek olması enfeksiyon kontrol önlemlerinin artırılması gerektiğini düşündürmektedir. Anahtar kelimeler : Antibiyotik direnci; kan kültürü; kan dolaşımı enfeksiyonu; mikroorganizma

Microorganism isolated from blood culture and their antimicrobial susceptibilities obtained at Kahramanmaraş Sütçü Imam University Health Practice and Research Hospital ABSTRACT Objective: Blood stream infections remain a major cause of morbidity and mortality. The aim of this study is to determine the types of microorganisms and antibiotic susceptibility isolated from blood cultures. Materials and Methods: 3719 isolates identified included in the study. Blood culture samples were incubated in BACT/ALERT 3D automated system. Identification and antibiotic susceptibility of microorganisms were done with Phoenix automated system. Results: The most frequent Gram negative bacteria were  Escherichia coli 227 (36.3%), Klebsiella pneumoniae 126 (20.1%). The most frequent Gram positive bacteria were 2245 (79.5%) coagulase negative Staphylococcus, 251 (8.8%) Enterococcus spp., 194 (6.87%)  Staphylococcus aureus. Carbapenems, aminoglycosides and tigecycline were most effective antibiotics against all Gram negatives. All Acinetobacter isolates were resistant to carbapenems. No resistance to vancomycin was detected Staphylococcus aureus. Methicilin resistance was 55% to Staphylococcus aureus, 84% to coagulase negative Staphylococcus. Vancomycin resistance was 9.7% to Enterococcus spp.. Conclusion: As a result, the high resistance rates of bacteria suggest that infection control measures should be increased. Key words : Antibiotic resistance; blood culture; blood stream infection; microorganism

Anahtar Kelimeler

Antibiyotik direnci, kan kültürü, kan dolaşımı enfeksiyonu, mikroorganizma

Kaynakça

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