Demographic, Histopathological and Immunohistochemical Characteristic Findings of Gastrointestinal Stromal Tumors: A Single-Centered Study

Abstract

Objective: Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal tumor of the gastrointestinal tract, arises from or is differentiated towards interstitial cell of Cajal. The aim of this study is to review the demographic, histopathological and immunohistochemical characteristics of cases diagnosed with GIST in the light of the literature.

Material and Methods: 
Forty-five GIST cases diagnosed between 2010 and 2018 in xxxxxx City Hospital's pathology clinic were included in the study. The cases were reevaluated retrospectively by hematoxylin-eosin sections and immunohistochemical staining.

Results: Twenty-one of the cases (46.66%) were female, and 24 (53.33%) were male. The average age was 64.9 years. 4/45 (8.88%) of the cases included in the study were in the very low risk, 20/45 (44.44%) were in the low risk, 8/45 (17.77%) were in the intermediate risk, and 13/45 cases (28.88%) were in the high-risk group.

Conclusion: Histopathology and immunohistochemical studies are important for the accurate diagnosis, classification, prognosis, and treatment in GISTs. The centers should prepare their report formats according to internationally accepted report samples and consensus criteria, and significant macroscopic and microscopic findings and immunohistochemical examination results should be given as a list at the end of the report.

Keywords

• Gastrointestinal stromal tumors
• histopathology
• immunohistochemistry staining

Gastrointestinal Stromal Tümörlerin Demografik, Histopatolojik, ve İmmünohistokimyasal Karakteristik Bulguları: Tek Merkez Çalışması

Abstract

Amaç: Gastrointestinal stromal tümör (GİST), gastrointestinal sistemin en sık görülen mezenkimal tümörüdür, interstisyel Cajal hücresinden kaynaklanır veya farklılaşır. Bu çalışmanın amacı GIST tanılı olguların demografik, histopatolojik ve immünohistokimyasal özelliklerini literatür ışığında gözden geçirmektir.

Gereç ve Yöntemler: Çalışmayaxxxxxx Şehir hastanesi patoloji kliniğinde, 2010-2018 yılları arasında tanı konulan 45 GİST olgusu dahil edildi. Olgular retrospektif olarak hematoksilen-eozin kesitleri ve immünohistokimyasal boyamaları ile yeniden değerlendirildi.

Bulgular: Olguların 21'i (%46,66) kadın, 24'ü (%53,33) erkekti. Yaş ortalaması 64.9 idi. Çalışmaya dahil edilen olguların 4/45'i(%8,88) çok düşük, 20/45'i (%44,44) düşük, 8/45'i (%17,77) orta derecedeydi ve 13 / 45 olgu (%28.88) yüksek risk grubundaydı.

Sonuç: GİST'lerde doğru tanı, sınıflandırma, prognoz ve tedavi için histopatoloji ve immünhistokimyasal çalışmalar önemlidir. Merkezler, rapor formatlarını uluslararası kabul görmüş rapor örneklerine ve fikir birliği kriterlerine göre hazırlamalı ve özel makroskobik ve mikroskobik bulgular ile immünohistokimyasal inceleme sonuçları raporun sonunda liste halinde verilmelidir.

Keywords

• gastroi̇ntesti̇nal stromal tümörler
• histopatoloji
• immunohistokimyasal boyama

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