Sarkoidozlu Hastalarda Kardiyak-Elektrofizyolojik Denge İndeksinin ve Elektrokardiyografik Değişimlerin Değerlendirilmesi

Abstract

Amaç: Kardiyak sarkoidoz (KS) farklı klinik bulgularla ortaya çıkabilir ve kötü bir prognoza sahiptir, ancak kalp nadiren tek başına etkilenir.Bu çalışmamızda, kalp tutulumu olan veya olmayan hastalarda elektrokardiyografi (EKG) kullanarak sarkoidozun aritmojenik etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Pulmoner sarkoidoz nedeniyle takip edilen toplam 61 hasta retrospektif olarak incelendi ve 50 sağlıklı gönüllü çalışmaya alındı. Sarkoidoz hastaları da kalp tutulumu olan veya olmayan olarak gruplandırıldı (n = 11 / n = 35). QRS, QT, Tp-e, P dalga morfolojisi manuel olarak ölçüldü. Daha sonra Tp-e / QT, Tp-e / QTc, QT / QRS (kardiyak elektrofizyolojik denge indeksi) ve QTc / QRS oranları hesaplandı ve gruplar arası karşılaştırıldı. Bulgular: EKG'de kalp hızı, QT / QTc aralığı, Tp-e aralıkları ve Tp-e / QT oranı ve PWD anlamlı olarak yüksek (p değerleri <0,018), QT / QRS oranı ile elde edilen iCEB veya iCEBc değerleri sarkoidoz grubunda daha düşüktü (p = 0.001). Kardiyak sarkoidozu olan ve olmayan grupta ise QTc, Tp-e / QT oranı ve iCEB dahil EKG parametreleri arasında bir ilişki bulamadık (sırasıyla p = 0.501, p = 0.753 ve p = 0.490). Sonuçlar: Bu çalışma sarkoidoz hastalarında daha düşük bir iCEB değeri ve daha yüksek repolarizasyon bulguları olduğunu göstermiştir. Bununla birlikte, kalp tutulumu olan veya olmayan arasında hiçbir fark yoktur.

Keywords

• Aritmi,
• elektrokardiyografi
• iCEB
• sarkoidoz

Evaluation of Index of Cardiac-Electrophysiological Balance and Electrocardiographic Alternations in Patients with Sarcoidosis

Abstract

Objective: Cardiac sarcoidosis (CS) can manifest with different clinical signs and has a poor prognosis, but the heart is rarely affected alone. We aim to evaluate the arrhythmogenic effects of sarcoidosis by using electrocardiography (ECG) in patients with or without cardiac involvement. Materials and Methods: A total of 61 patients under follow-up for pulmonary sarcoidosis were retrospectively reviewed and 50 healthy volunteers were enrolled in the study. Sarcoidosis patients were also grouped as with or without cardiac involvement (n=11/ n=35). QRS, QT, Tp-e, P wave morphology were measured manually. Then, Tp-e/QT, Tp-e/QTc, QT/QRS (index of cardiac electrophysiological balance), and QTc/QRS ratios were calculated and compared between groups. Results: Heart rate on ECG, QT/QTc interval, Tp-e intervals and Tp-e/QT ratio and PWD were significantly higher (p values < 0.018) and iCEB or iCEBc values, obtained with the QT/QRS ratio, were lower in the sarcoidosis group (p = 0.001). And we could not find a relationship between non-cardiac and CS and ECG parameters including QTc, Tp-e/QT ratio and iCEB (p= 0.501, p= 0.753 and p=0.490, respectively). Conclusion: The present study demonstrated a lower iCEB value and higher repolarization findings in sarcoidosis patient. However, there are no differences between with or without cardiac involvement.

Keywords

• Arrhythmia,
• electrocardiography
• iCEB
• sarcoidosis

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