The Effect of The Thrombolytic Treatment on Inflammatory Markers in Male Patients with Pulmonary Thromboembolism

Abstract

Objective: Neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios play an important role in monitoring the progression of the disease and determining the course of the disease in patients with acute pulmonary thromboembolism (APTE). This study aims to determine whether there is any change in NLR, PLR, and C-reactive protein (CRP) in patients with APTE receiving thrombolytic therapy. Materials and Methods: Sixty-five male patients with shortness of breath, chest pain, and palpitations, who were diagnosed with APTE by examinations and thorax computed tomography angiography, and who were hospitalized and given thrombolytic therapy were included in the study. The files of these patients were scanned retrospectively, and NLR and PLR and CRP values were recorded 1-2 days before and 1-4 days after thrombolytic therapy. Then, it was checked whether there was a difference between pre-treatment and post-treatment values. Results: NLR, PLR, CRP and systolic pulmonary artery pressure values decreased statistically significantly in patients with APTE by thrombolytic therapy. Conclusion: NLR, PLR, CRP and sPAP values were found to be statistically significantly decreased with thrombolytic treatment.

Keywords

• C-Reactive Protein
• Inflammation
• Acute Pulmonary Thromboembolism

Pulmoner Tromboembolisi Olan Erkek Hastalarda Trombolitik Tedavinin İnflamatuvar Belirteçler Üzerindeki Etkisi

Abstract

Giriş: Nötrofil-lenfosit (NLR) ve trombosit-lenfosit (PLR) oranları, akut pulmoner tromboembolizm (APTE) olan hastalarda, hastalığın ilerlemesinin izlenmesinde ve hastalığın seyrinin belirlenmesinde önemli bir rol oynamaktadır. Bu çalışma, trombolitik tedavi alan APTE'li hastalarda NLR, PLR ve C-reaktif protein (CRP) 'de herhangi bir değişiklik olup olmadığını belirlemeyi amaçlamıştır. Yöntemler: Muayeneler ve toraks bilgisayarlı tomografi anjiyografisi ile APTE tanısı konulan, nefes darlığı, göğüs ağrısı ve çarpıntı nedeniyle hastaneye yatırılıp trombolitik tedavi verilen 65 erkek hasta, çalışmaya dahil edildi. Bu hastaların dosyaları geriye dönük olarak tarandı ve trombolitik tedaviden 1-2 gün önce ve 1-4 gün sonra NLR, PLR ve CRP değerleri kaydedildi. Daha sonra tedavi öncesi ve sonrası değerler arasında fark olup olmadığı kontrol edildi. Bulgular: Trombolitik tedavi ile APTE'li hastalarda NLR, PLR, CRP ve sistolik pulmoner arter basınç değerleri istatistiksel olarak anlamlı azaldı. Sonuç: Trombolitik tedavi ile NLR, PLR, CRP ve sPAP değerlerinin istatistiksel olarak anlamlı derecede azaldığı bulundu.

Keywords

• C-Reaktif Protein
• İnflamasyon
• Akut Akciğer Tromboembolisi

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