Clinical and Laboratory Characteristics of Patients with Infective Endocarditis: A single-center experience

Abstract

Objective: This study aimed to evaluate the clinical presentations, outcomes, and changes over 8 years period of infective endocarditis (IE) patients in a tertiary hospital in Turkey and to identify predictors of mortality. Materials and Methods: All adult patients who were hospitalized with a diagnosis of definite IE were included in the study. The data were analyzed both collectively and separately in two consecutive four-year periods i.e. 2010-2013 and 2014-2017. Results: There were 72 IE cases in the study. Male/female ratio was 1.57:1 (44 males,28 females). The mean age of the patients was 48.5±17.6 years. Staphylococci were the most common agents (44%). Independent predictors of mortality were heart failure, the invasive procedure before IE, and lower platelet level. Increased invasive procedures before IE and enterococcal endocarditis were found significantly to be higher during the last period (2014-2017). Conclusions: IE is still a serious and deadly disease in the 21st century. Our data indicate that invasive procedures have been increasing before IE and this increase with associated poor prognosis.

Keywords

• Endocarditis
• Epidemiology
• Mortality

Enfektif Endokardit Hastalarının Klinik ve Laboratuvar Özellikleri: Tek Merkez Deneyimi

Abstract

Amaç: Bu çalışmada, Türkiye'de üçüncü basamak bir hastanede yatan enfektif endokardit (EE) tanılı hastaların klinik özelliklerini, sonuçlarını ve sekiz yıllık dönemdeki değişiklikleri değerlendirmek ve mortalite risk faktörlerini belirlemek amaçlandı. Gereç ve Yöntemler: Çalışmaya kesin EE tanısıyla yatırılarak takip edilen tüm erişkin hastalar dahil edildi. Çalışma verileri toplu şekilde ve iki ardışık dört yıllık dönem şeklinde (2010-2013 ve 2014-2017) analiz edildi. Bulgular: Çalışmada 72 EE hastası mevcuttu. Erkek/kadın cinsiyet oranı 1,57:1 (44 erkek, 28 kadın) idi. Hastaların ortalama yaşı 48,5±17,6 yıldı. Stafilokoklar en yaygın etken olarak bulundu (%44). Kalp yetmezliği, EE öncesi girişimsel işlem varlığı ve düşük trombosit seviyesi, mortalite için bağımsız risk faktörü olarak bulundu. EE öncesi artan girişimsel işlem varlığı ve enterokokal endokardit, son dönemde (2014-2017) anlamlı olarak daha yüksek bulundu. Sonuç: EE, 21. yüzyılda hala ciddi ve ölümcül bir hastalıktır. Verilerimiz, enfektif endokardit tanısı öncesinde girişimsel işlem varlığının artmakta olduğunu ve bu durumun kötü prognozla ilişkili olduğunu göstermektedir.

Keywords

• Endokardit
• Epidemiyoloji
• Mortalite

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