Ferritin, fibrinojen ve prokalsitonin düzeyleri gebelerde COVID-19 klinik seyrini nasıl etkiler?

Abstract

Amaç: Coronavirus Disease 2019 (COVID-19) birçok insanı olduğu kadar gebeleri de etkileyen bir pandemidir. Çalışmamızın amacı inflamatuar belirteçlerin gebelerde COVID-19 seyrine etkisini araştırmaktır. Gereç ve yöntem: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pozitif olan 125 ve negatif olan 40 gebenin dahil edildiği bu kesitsel tipe tanımlayıcı çalışmada, COVID-19 olan hastalar oksijen satürasyonu, akciğer tutulumu bulgularına göre hafif orta ve ağır olarak gruplandırılmıştır. Fibirnojen, ferritin ve prokalsitonin değerleri karşılaştırılmıştır. Bulgular: SARS-CoV-2 durumuna göre gebelerin ferritin (p=0,241) ve prokalsitonin (p=0,579) değerleri arasında da anlamlı fark saptanmazken, testi pozitif gebelerin fibrinojen değerleri anlamlı olarak yüksek bulunmuştur (p<0,001). SARS-CoV-2 pozitif olan katılımcıları kendi içerisinde klinik durumuna hafif, orta ve ağır olarak gruplandırıp baktığımızda ise; fibrinojen (p<0,001) değerleri arasında anlamlı fark saptanmıştır. İkili karşılaştırmada klinik seyri hafif olan grupta fibrinojen değeri orta (p<0,001) ve ağır (p<0,001) olan gruptan, klinik seyri orta olan grubun fibrinojen değeri ise ağır olan gruptan anlamlı olarak düşük saptanmıştır (p=0,007) Sonuç: Hastalığın ağırlığı arttıkça fibrinojen seviyelerinin de arttığını tespit ettik. Fibrinojen gebelerde COVID-19 klinik durumunun ağırlığı ile ilgili bir gösterge olabilir ancak bu bulguyu güçlendirmek için daha büyük örnekleme sahip prospektif, izleme dayalı çalışmalar gerekmektedir.

Keywords

• COVID-19
• Gebelik
• Ferritin
• Fibrinojen
• Prokalsitonin

How do levels of ferritin, fibrinogen and procalcitonin affect the clinical course of COVID-19 in pregnant women?

Abstract

Objective: Coronavirus disease 2019 (COVID 19) is a pandemic affecting pregnant women as well as lots of people. The aim of our study is to investigate the effects of inflammatory markers on the course of COVID-19 in pregnant women. Materials and methods: In this cross-sectional descriptive study, which included 125 pregnant women who were positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 40 women who were negative, patients with COVID-19 were grouped as mild, moderate, and severe according to oxygen saturation, lung involvement findings. Fibrinogen, ferritin, and procalcitonin values of the participants were compared. Results: While there was no significant difference between the ferritin (p = 0,241) and procalcitonin (p = 0,579) values of pregnant women according to the SARS-CoV-2 status, the fibrinogen values of pregnant women with positive test were found to be significantly higher (p<0,001). When we categorize the participants who are positive for SARS-CoV-2 as mild, moderate, and severe; a significant difference was found between fibrinogen (p<0,001) values. In paired comparison, the fibrinogen value of the group with mild disease was found to be significantly lower than the group with moderate (p<0,001) and severe (p<0,001), and the group with a moderate disease compared to the group with severe (p = 0,007). Conclusion: We found that as the severity of the disease increased, fibrinogen levels also increased. Fibrinogen may be an indicator of the severity of the COVID-19 clinical course in pregnant women, but prospective, follow-up studies with larger samples are required to reinforce this finding.

Keywords

• COVID-19; pregnancy; fibrinogen; ferritin; procalcitonin

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